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Volumn 6, Issue 3, 2012, Pages 255-265

Inhaled treprostinil for the treatment of pulmonary arterial hypertension

Author keywords

administration; analogs and derivatives; epoprostenol; inhalation; pulmonary arterial hypertension; pulmonary circulation; treprostinil

Indexed keywords

AMBRISENTAN; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; BOSENTAN; FRACTALKINE; ILOPROST; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PLACEBO; PROSTACYCLIN; RANTES; SILDENAFIL; TADALAFIL; UNIPROST;

EID: 84863886265     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/ers.12.23     Document Type: Review
Times cited : (11)

References (78)
  • 1
    • 67649632034 scopus 로고    scopus 로고
    • Diagnosis and assessment of pulmonary arterial hypertension
    • Badesch DB, Champion HC, Sanchez MA et al. Diagnosis and assessment of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 54(Suppl. 1), S55-S66 (2009
    • (2009) J. Am. Coll. Cardiol. , vol.54 , Issue.SUPPL. 1
    • Badesch, D.B.1    Champion, H.C.2    Sanchez, M.A.3
  • 2
    • 67649579669 scopus 로고    scopus 로고
    • Updated clinical classification of pulmonary hypertension
    • Simonneau G, Robbins IM, Beghetti M et al. Updated clinical classification of pulmonary hypertension. J. Am. Coll. Cardiol. 54(Suppl. 1), S43-S54 (2009
    • (2009) J. Am. Coll. Cardiol. , vol.54 , Issue.SUPPL. 1
    • Simonneau, G.1    Robbins, I.M.2    Beghetti, M.3
  • 3
    • 33646269035 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension in France: Results from a national registry
    • Humbert M, Sitbon O, Chaouat A et al. Pulmonary arterial hypertension in France: Results from a national registry. Am. J. Respir. Crit. Care Med. 173(9), 1023-1030 (2006
    • (2006) Am. J. Respir. Crit. Care Med. , vol.173 , Issue.9 , pp. 1023-1030
    • Humbert, M.1    Sitbon, O.2    Chaouat, A.3
  • 4
    • 0025837793 scopus 로고
    • Survival in patients with primary pulmonary hypertension results from a national prospective registry
    • D'Alonzo GE, Barst RJ, Ayres SM et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann. Intern. Med. 115(5), 343-349 (1991
    • (1991) Ann. Intern. Med. , vol.115 , Issue.5 , pp. 343-349
    • D'Alonzo, G.E.1    Barst, R.J.2    Ayres, S.M.3
  • 5
    • 0030031888 scopus 로고    scopus 로고
    • A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension
    • The Primary Pulmonary Hypertension Study Group
    • Barst RJ, Rubin LJ, Long WA et al. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group. N. Engl. J. Med. 334(5), 296-302 (1996
    • (1996) N. Engl. J. Med. , vol.334 , Issue.5 , pp. 296-302
    • Barst, R.J.1    Rubin, L.J.2    Long, W.A.3
  • 7
    • 77955953602 scopus 로고    scopus 로고
    • Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension
    • French Pulmonary Arterial Hypertension Network
    • Humbert M, Sitbon O, Yaici A et al.; French Pulmonary Arterial Hypertension Network. Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension. Eur. Respir. J. 36(3), 549-555 (2010
    • (2010) Eur. Respir. J. , vol.36 , Issue.3 , pp. 549-555
    • Humbert, M.1    Sitbon, O.2    Yaici, A.3
  • 8
    • 67649588196 scopus 로고    scopus 로고
    • Updated evidence-Based treatment algorithm in pulmonary arterial hypertension
    • Barst RJ, Gibbs JS, Ghofrani HA et al. Updated evidence-Based treatment algorithm in pulmonary arterial hypertension. J. Am. Coll. Cardiol. 54(Suppl. 1), S78-S84 (2009
    • (2009) J. Am. Coll. Cardiol. , vol.54 , Issue.SUPPL. 1
    • Barst, R.J.1    Gibbs, J.S.2    Ghofrani, H.A.3
  • 9
    • 0035818316 scopus 로고    scopus 로고
    • Effects of the dual endothelinreceptor antagonist bosentan in patients with pulmonary hypertension: A randomised placebo-Controlled study
    • Channick RN, Simonneau G, Sitbon O et al. Effects of the dual endothelinreceptor antagonist bosentan in patients with pulmonary hypertension: A randomised placebo-Controlled study. Lancet 358(9288), 1119-1123 (2001
    • (2001) Lancet , vol.358 , Issue.9288 , pp. 1119-1123
    • Channick, R.N.1    Simonneau, G.2    Sitbon, O.3
  • 10
    • 26444534291 scopus 로고    scopus 로고
    • Sildenafil citrate therapy for pulmonary arterial hypertension
    • Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group
    • Galiè N, Ghofrani HA, Torbicki A et al.; Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group. Sildenafil citrate therapy for pulmonary arterial hypertension. N. Engl. J. Med. 353(20), 2148-2157 (2005
    • (2005) N. Engl. J. Med. , vol.353 , Issue.20 , pp. 2148-2157
    • Galiè, N.1    Ghofrani, H.A.2    Torbicki, A.3
  • 11
    • 46449124591 scopus 로고    scopus 로고
    • Ambrisentan for the treatment of pulmonary arterial hypertension: Results of the ambrisentan in pulmonary arterial hypertension, randomized, double-Blind, placebocontrolled, multicenter, efficacy (ARIES) study 1 and 2
    • Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy Studies (ARIES) Group
    • Galiè N, Olschewski H, Oudiz RJ et al.; Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy Studies (ARIES) Group. Ambrisentan for the treatment of pulmonary arterial hypertension: Results of the ambrisentan in pulmonary arterial hypertension, randomized, double-Blind, placebocontrolled, multicenter, efficacy (ARIES) study 1 and 2. Circulation 117(23), 3010-3019 (2008
    • (2008) Circulation , vol.117 , Issue.23 , pp. 3010-3019
    • Galiè, N.1    Olschewski, H.2    Oudiz, R.J.3
  • 12
    • 67649523052 scopus 로고    scopus 로고
    • Tadalafil therapy for pulmonary arterial hypertension
    • Pulmonary Arterial Hypertension and Response to Tadalafil (PHIRST) Study Group
    • Galiè N, Brundage BH, Ghofrani HA et al.; Pulmonary Arterial Hypertension and Response to Tadalafil (PHIRST) Study Group. Tadalafil therapy for pulmonary arterial hypertension. Circulation 119(22), 2894-2903 (2009
    • (2009) Circulation , vol.119 , Issue.22 , pp. 2894-2903
    • Galiè, N.1    Brundage, B.H.2    Ghofrani, H.A.3
  • 13
    • 42949166212 scopus 로고    scopus 로고
    • Prostacyclin therapies for the treatment of pulmonary arterial hypertension
    • Gomberg-Maitland M, Olschewski H. Prostacyclin therapies for the treatment of pulmonary arterial hypertension. Eur. Respir. J. 31(4), 891-901 (2008
    • (2008) Eur. Respir. J. , vol.31 , Issue.4 , pp. 891-901
    • Gomberg-Maitland, M.1    Olschewski, H.2
  • 14
    • 2542438681 scopus 로고    scopus 로고
    • Prostacyclin and its analogues in the treatment of pulmonary hypertension
    • Olschewski H, Rose F, Schermuly R et al. Prostacyclin and its analogues in the treatment of pulmonary hypertension. Pharmacol. Ther. 102(2), 139-153 (2004
    • (2004) Pharmacol. Ther. , vol.102 , Issue.2 , pp. 139-153
    • Olschewski, H.1    Rose, F.2    Schermuly, R.3
  • 15
    • 0028597038 scopus 로고
    • Survival in primary pulmonary hypertension with long-Term continuous intravenous prostacyclin
    • Barst RJ, Rubin LJ, McGoon MD, Caldwell EJ, Long WA, Levy PS. Survival in primary pulmonary hypertension with long-Term continuous intravenous prostacyclin. Ann. Intern. Med. 121(6), 409-415 (1994
    • (1994) Ann. Intern. Med. , vol.121 , Issue.6 , pp. 409-415
    • Barst, R.J.1    Rubin, L.J.2    McGoon, M.D.3    Caldwell, E.J.4    Long, W.A.5    Levy, P.S.6
  • 16
    • 0027438646 scopus 로고
    • Prostacyclin (epoprostenol) and heart-Lung transplantation as treatments for severe pulmonary hypertension
    • Higenbottam TW, Spiegelhalter D, Scott JP et al. Prostacyclin (epoprostenol) and heart-Lung transplantation as treatments for severe pulmonary hypertension. Br. Heart J. 70(4), 366-370 (1993
    • (1993) Br. Heart J. , vol.70 , Issue.4 , pp. 366-370
    • Higenbottam, T.W.1    Spiegelhalter, D.2    Scott, J.P.3
  • 17
    • 0025356811 scopus 로고
    • Treatment of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol) results of a randomized trial
    • Rubin LJ, Mendoza J, Hood M et al. Treatment of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol). Results of a randomized trial. Ann. Intern. Med. 112(7), 485-491 (1990
    • (1990) Ann. Intern. Med. , vol.112 , Issue.7 , pp. 485-491
    • Rubin, L.J.1    Mendoza, J.2    Hood, M.3
  • 18
    • 0028952366 scopus 로고
    • Acute hemodynamic effects of the prostacyclin analog 15AU81 in severe congestive heart failure
    • Patterson JH, Adams KF Jr, Gheorghiade M et al. Acute hemodynamic effects of the prostacyclin analog 15AU81 in severe congestive heart failure. Am. J. Cardiol. 75(3), 26A-33A (1995
    • (1995) Am. J. Cardiol. , vol.75 , Issue.3
    • Patterson, J.H.1    Adams Jr., K.F.2    Gheorghiade, M.3
  • 19
    • 0034510312 scopus 로고    scopus 로고
    • Trial of a novel prostacyclin analog, UT-15, in patients with severe intermittent claudication
    • Mohler ER, Klugherz B, Goldman R, Kimmel SE, Wade M, Sehgal CM. Trial of a novel prostacyclin analog, UT-15, in patients with severe intermittent claudication. Vasc. Med. 5(4), 231-237 (2000
    • (2000) Vasc. Med. , vol.5 , Issue.4 , pp. 231-237
    • Mohler III, E.R.1    Klugherz, B.2    Goldman, R.3    Kimmel, S.E.4    Wade, M.5    Sehgal, C.M.6
  • 20
    • 0037086133 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: A double-Blind, randomized, placebocontrolled trial
    • Treprostinil Study Group
    • Simonneau G, Barst RJ, Galie N et al.; Treprostinil Study Group. Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: A double-Blind, randomized, placebocontrolled trial. Am. J. Respir. Crit. Care Med. 165(6), 800-804 (2002
    • (2002) Am. J. Respir. Crit. Care Med. , vol.165 , Issue.6 , pp. 800-804
    • Simonneau, G.1    Barst, R.J.2    Galie, N.3
  • 21
    • 3242786431 scopus 로고    scopus 로고
    • Pharmacokinetics and steadystate bioequivalence of treprostinil sodium (Remodulin) administered by the intravenous and subcutaneous route to normal volunteers
    • Laliberte K, Arneson C, Jeffs R, Hunt T, Wade M. Pharmacokinetics and steadystate bioequivalence of treprostinil sodium (Remodulin) administered by the intravenous and subcutaneous route to normal volunteers. J. Cardiovasc. Pharmacol. 44(2), 209-214 (2004
    • (2004) J. Cardiovasc. Pharmacol. , vol.44 , Issue.2 , pp. 209-214
    • Laliberte, K.1    Arneson, C.2    Jeffs, R.3    Hunt, T.4    Wade, M.5
  • 22
    • 30444458863 scopus 로고    scopus 로고
    • Transition from intravenous epoprostenol to intravenous treprostinil in pulmonary hypertension
    • Gomberg-Maitland M, Tapson VF, Benza RL et al. Transition from intravenous epoprostenol to intravenous treprostinil in pulmonary hypertension. Am. J. Respir. Crit. Care Med. 172(12), 1586-1589 (2005
    • (2005) Am. J. Respir. Crit. Care Med. , vol.172 , Issue.12 , pp. 1586-1589
    • Gomberg-Maitland, M.1    Tapson, V.F.2    Benza, R.L.3
  • 23
    • 74849116556 scopus 로고    scopus 로고
    • Exercise improvement and plasma biomarker changes with intravenous treprostinil therapy for pulmonary arterial hypertension: A placebo-Controlled trial
    • TRUST Study Group
    • Hiremath J, Thanikachalam S, Parikh K et al.; TRUST Study Group. Exercise improvement and plasma biomarker changes with intravenous treprostinil therapy for pulmonary arterial hypertension: A placebo-Controlled trial. J. Heart Lung Transplant. 29(2), 137-149 (2010
    • (2010) J. Heart Lung Transplant. , vol.29 , Issue.2 , pp. 137-149
    • Hiremath, J.1    Thanikachalam, S.2    Parikh, K.3
  • 24
    • 33645119109 scopus 로고    scopus 로고
    • Safety and efficacy of IV treprostinil for pulmonary arterial hypertension: A prospective, multicenter, open-Label, 12-Week trial
    • Tapson VF, Gomberg-Maitland M, McLaughlin VV et al. Safety and efficacy of IV treprostinil for pulmonary arterial hypertension: A prospective, multicenter, open-Label, 12-Week trial. Chest 129(3), 683-688 (2006
    • (2006) Chest , vol.129 , Issue.3 , pp. 683-688
    • Tapson, V.F.1    Gomberg-Maitland, M.2    McLaughlin, V.V.3
  • 25
    • 0036682273 scopus 로고    scopus 로고
    • Inhaled iloprost for severe pulmonary hypertension
    • Aerosolized Iloprost Randomized Study Group
    • Olschewski H, Simonneau G, Galiè N et al.; Aerosolized Iloprost Randomized Study Group. Inhaled iloprost for severe pulmonary hypertension. N. Engl. J. Med. 347(5), 322-329 (2002
    • (2002) N. Engl. J. Med. , vol.347 , Issue.5 , pp. 322-329
    • Olschewski, H.1    Simonneau, G.2    Galiè, N.3
  • 27
    • 73749086478 scopus 로고    scopus 로고
    • A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension
    • Mubarak KK. A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension. Respir. Med. 104(1), 9-21 (2010
    • (2010) Respir. Med. , vol.104 , Issue.1 , pp. 9-21
    • Mubarak, K.K.1
  • 28
    • 33846477487 scopus 로고    scopus 로고
    • Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-Receptor binding specificities
    • Aronoff DM, Peres CM, Serezani CH et al. Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-Receptor binding specificities. J. Immunol. 178(3), 1628-1634 (2007
    • (2007) J. Immunol. , vol.178 , Issue.3 , pp. 1628-1634
    • Aronoff, D.M.1    Peres, C.M.2    Serezani, C.H.3
  • 29
    • 46849122659 scopus 로고    scopus 로고
    • Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension
    • Lai YJ, Pullamsetti SS, Dony E et al. Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension. Am. J. Respir. Crit. Care Med. 178(2), 188-196 (2008
    • (2008) Am. J. Respir. Crit. Care Med. , vol.178 , Issue.2 , pp. 188-196
    • Lai, Y.J.1    Pullamsetti, S.S.2    Dony, E.3
  • 30
    • 79951674038 scopus 로고    scopus 로고
    • Role of prostanoid IP and EP receptors in mediating vasorelaxant responses to PGI2 analogues in rat tail artery: Evidence for Gi/o modulation via EP3 receptors
    • Orie NN, Clapp LH. Role of prostanoid IP and EP receptors in mediating vasorelaxant responses to PGI2 analogues in rat tail artery: EVIDENCE for Gi/o modulation via EP3 receptors. Eur. J. Pharmacol. 654(3), 258-265 (2011
    • (2011) Eur. J. Pharmacol. , vol.654 , Issue.3 , pp. 258-265
    • Orie, N.N.1    Clapp, L.H.2
  • 31
    • 78349278479 scopus 로고    scopus 로고
    • Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension
    • Falcetti E, Hall SM, Phillips PG et al. Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 182(9), 1161-1170 (2010
    • (2010) Am. J. Respir. Crit. Care Med. , vol.182 , Issue.9 , pp. 1161-1170
    • Falcetti, E.1    Hall, S.M.2    Phillips, P.G.3
  • 33
    • 67649599147 scopus 로고    scopus 로고
    • Cellular and molecular basis of pulmonary arterial hypertension
    • Morrell NW, Adnot S, Archer SL et al. Cellular and molecular basis of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 54(Suppl. 1), S20-S31 (2009
    • (2009) J. Am. Coll. Cardiol. , vol.54 , Issue.SUPPL. 1
    • Morrell, N.W.1    Adnot, S.2    Archer, S.L.3
  • 34
    • 77955172689 scopus 로고    scopus 로고
    • Smad-Dependent and smad-Independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo
    • Yang J, Li X, Al-Lamki RS et al. Smad-Dependent and smad-Independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo. Circ. Res. 107(2), 252-262 (2010
    • (2010) Circ. Res. , vol.107 , Issue.2 , pp. 252-262
    • Yang, J.1    Li, X.2    Al-Lamki, R.S.3
  • 35
    • 0037134011 scopus 로고    scopus 로고
    • Role of prostacyclin in the cardiovascular response to thromboxane A2
    • Cheng Y, Austin SC, Rocca B et al. Role of prostacyclin in the cardiovascular response to thromboxane A2. Science 296(5567), 539-541 (2002
    • (2002) Science , vol.296 , Issue.5567 , pp. 539-541
    • Cheng, Y.1    Austin, S.C.2    Rocca, B.3
  • 36
    • 44649145119 scopus 로고    scopus 로고
    • Reduced number and activity of circulating endothelial progenitor cells in patients with idiopathic pulmonary arterial hypertension
    • Junhui Z, Xingxiang W, Guosheng F, Yunpeng S, Furong Z, Junzhu C. Reduced number and activity of circulating endothelial progenitor cells in patients with idiopathic pulmonary arterial hypertension. Respir. Med. 102(7), 1073-1079 (2008
    • (2008) Respir. Med. , vol.102 , Issue.7 , pp. 1073-1079
    • Junhui, Z.1    Xingxiang, W.2    Guosheng, F.3    Yunpeng, S.4    Furong, Z.5    Junzhu, C.6
  • 37
    • 77957914450 scopus 로고    scopus 로고
    • Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury
    • Pendergrass SA, Hayes E, Farina G et al. Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury. PLoS One 5(8), e12106 (2010
    • (2010) PLoS One , vol.5 , Issue.8
    • Pendergrass, S.A.1    Hayes, E.2    Farina, G.3
  • 38
    • 60649095647 scopus 로고    scopus 로고
    • Effects of a stable prostacyclin analogue beraprost sodium on VEGF and PAI-1 gene expression in vascular smooth muscle cells
    • Atsuta H, Uchiyama T, Kanai H et al. Effects of a stable prostacyclin analogue beraprost sodium on VEGF and PAI-1 gene expression in vascular smooth muscle cells. Int. J. Cardiol. 132(3), 411-418 (2009
    • (2009) Int. J. Cardiol. , vol.132 , Issue.3 , pp. 411-418
    • Atsuta, H.1    Uchiyama, T.2    Kanai, H.3
  • 39
    • 60349120941 scopus 로고    scopus 로고
    • Peroxisome proliferator-Activated receptor alpha is crucial for iloprost-Induced in vivo angiogenesis and vascular endothelial growth factor upregulation
    • Biscetti F, Gaetani E, Flex A et al. Peroxisome proliferator-Activated receptor alpha is crucial for iloprost-Induced in vivo angiogenesis and vascular endothelial growth factor upregulation. J. Vasc. Res. 46(2), 103-108 (2009
    • (2009) J. Vasc. Res. , vol.46 , Issue.2 , pp. 103-108
    • Biscetti, F.1    Gaetani, E.2    Flex, A.3
  • 40
    • 34447563745 scopus 로고    scopus 로고
    • Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes
    • Fontana M, Olschewski H, Olschewski A, Schlüter KD. Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes. Br. J. Pharmacol. 151(6), 779-786 (2007
    • (2007) Br. J. Pharmacol. , vol.151 , Issue.6 , pp. 779-786
    • Fontana, M.1    Olschewski, H.2    Olschewski, A.3    Schlüter, K.D.4
  • 41
    • 0029062419 scopus 로고
    • Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension
    • Humbert M, Monti G, Brenot F et al. Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am. J. Respir. Crit. Care Med. 151(5), 1628-1631 (1995
    • (1995) Am. J. Respir. Crit. Care Med. , vol.151 , Issue.5 , pp. 1628-1631
    • Humbert, M.1    Monti, G.2    Brenot, F.3
  • 42
    • 12144290664 scopus 로고    scopus 로고
    • Epoprostenol therapy decreases elevated circulating levels of monocyte chemoattractant protein-1 in patients with primary pulmonary hypertension
    • Katsushi H, Kazufumi N, Hideki F et al. Epoprostenol therapy decreases elevated circulating levels of monocyte chemoattractant protein-1 in patients with primary pulmonary hypertension. Circ. J. 68(3), 227-231 (2004
    • (2004) Circ. J. , vol.68 , Issue.3 , pp. 227-231
    • Katsushi, H.1    Kazufumi, N.2    Hideki, F.3
  • 43
    • 78650107038 scopus 로고    scopus 로고
    • Inflammation, immunological reaction and role of infection in pulmonary hypertension
    • Pullamsetti SS, Savai R, Janssen W et al. Inflammation, immunological reaction and role of infection in pulmonary hypertension. Clin. Microbiol. Infect. 17(1), 7-14 (2011
    • (2011) Clin. Microbiol. Infect. , vol.17 , Issue.1 , pp. 7-14
    • Pullamsetti, S.S.1    Savai, R.2    Janssen, W.3
  • 44
    • 0037031932 scopus 로고    scopus 로고
    • The prostacyclin analogue treprostinil blocks NFkappaB nuclear translocation in human alveolar macrophages
    • Raychaudhuri B, Malur A, Bonfield TL et al. The prostacyclin analogue treprostinil blocks NFkappaB nuclear translocation in human alveolar macrophages. J. Biol. Chem. 277(36), 33344-33348 (2002
    • (2002) J. Biol. Chem. , vol.277 , Issue.36 , pp. 33344-33348
    • Raychaudhuri, B.1    Malur, A.2    Bonfield, T.L.3
  • 45
    • 33846198409 scopus 로고    scopus 로고
    • Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells
    • Zhou W, Hashimoto K, Goleniewska K et al. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J. Immunol. 178(2), 702-710 (2007
    • (2007) J. Immunol. , vol.178 , Issue.2 , pp. 702-710
    • Zhou, W.1    Hashimoto, K.2    Goleniewska, K.3
  • 46
    • 0036839051 scopus 로고    scopus 로고
    • Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary hypertension in rats
    • Ikeda Y, Yonemitsu Y, Kataoka C et al. Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary hypertension in rats. Am. J. Physiol. Heart Circ. Physiol. 283(5), H2021-H2028 (2002
    • (2002) Am. J. Physiol. Heart Circ. Physiol. , vol.283 , Issue.5
    • Ikeda, Y.1    Yonemitsu, Y.2    Kataoka, C.3
  • 47
    • 73349114919 scopus 로고    scopus 로고
    • Prostacyclin inhibits IFN-Gamma-Stimulated cytokine expression by reduced recruitment of CBP/ p300 to STAT1 in a SOCS-1-Independent manner
    • Strassheim D, Riddle SR, Burke DL, Geraci MW, Stenmark KR. Prostacyclin inhibits IFN-Gamma-Stimulated cytokine expression by reduced recruitment of CBP/ p300 to STAT1 in a SOCS-1-Independent manner. J. Immunol. 183(11), 6981-6988 (2009
    • (2009) J. Immunol. , vol.183 , Issue.11 , pp. 6981-6988
    • Strassheim, D.1    Riddle, S.R.2    Burke, D.L.3    Geraci, M.W.4    Stenmark, K.R.5
  • 48
    • 33847739748 scopus 로고    scopus 로고
    • Bloodstream infections among patients treated with intravenous epoprostenol or intravenous treprostinil for pulmonary arterial hypertension - Seven sites United States 2003-2006
    • Centers for Disease Control and Prevention (CDC)
    • Centers for Disease Control and Prevention (CDC). Bloodstream infections among patients treated with intravenous epoprostenol or intravenous treprostinil for pulmonary arterial hypertension - seven sites, United States, 2003-2006. MMWR Morb. Mortal. Wkly Rep. 56(8), 170-172 (2007
    • (2007) MMWR Morb. Mortal. Wkly Rep. , vol.56 , Issue.8 , pp. 170-172
  • 49
    • 40949101444 scopus 로고    scopus 로고
    • Bloodstream infections in patients given treatment with intravenous prostanoids
    • Kallen AJ, Lederman E, Balaji A et al. Bloodstream infections in patients given treatment with intravenous prostanoids. Infect. Control Hosp. Epidemiol. 29(4), 342-349 (2008
    • (2008) Infect. Control Hosp. Epidemiol. , vol.29 , Issue.4 , pp. 342-349
    • Kallen, A.J.1    Lederman, E.2    Balaji, A.3
  • 50
    • 84855468771 scopus 로고    scopus 로고
    • The effect of diluent pH on bloodstream infection rates in patients receiving IV treprostinil for pulmonary arterial hypertension
    • Rich JD, Glassner C, Wade M et al. The effect of diluent pH on bloodstream infection rates in patients receiving IV treprostinil for pulmonary arterial hypertension. Chest 141(1), 36-42 (2012
    • (2012) Chest 141 , vol.1 , pp. 36-42
    • Rich, J.D.1    Glassner, C.2    Wade, M.3
  • 51
    • 33749537060 scopus 로고    scopus 로고
    • Favorable effects of inhaled treprostinil in severe pulmonary hypertension: Results from randomized controlled pilot studies
    • Voswinckel R, Enke B, Reichenberger F et al. Favorable effects of inhaled treprostinil in severe pulmonary hypertension: Results from randomized controlled pilot studies. J. Am. Coll. Cardiol. 48(8), 1672-1681 (2006
    • (2006) J. Am. Coll. Cardiol. , vol.48 , Issue.8 , pp. 1672-1681
    • Voswinckel, R.1    Enke, B.2    Reichenberger, F.3
  • 52
    • 0345733707 scopus 로고    scopus 로고
    • Absolute bioavailability and pharmacokinetics of treprostinil sodium administered by acute subcutaneous infusion
    • Wade M, Baker FJ, Roscigno R, DellaMaestra W, Hunt TL, Lai AA. Absolute bioavailability and pharmacokinetics of treprostinil sodium administered by acute subcutaneous infusion. J. Clin. Pharmacol. 44(1), 83-88 (2004
    • (2004) J. Clin. Pharmacol. , vol.44 , Issue.1 , pp. 83-88
    • Wade, M.1    Baker, F.J.2    Roscigno, R.3    DellaMaestra, W.4    Hunt, T.L.5    Lai, A.A.6
  • 53
    • 33748931278 scopus 로고    scopus 로고
    • Safety and efficacy of inhaled treprostinil as add-On therapy to bosentan in pulmonary arterial hypertension
    • Channick RN, Olschewski H, Seeger W, Staub T, Voswinckel R, Rubin LJ. Safety and efficacy of inhaled treprostinil as add-On therapy to bosentan in pulmonary arterial hypertension. J. Am. Coll. Cardiol. 48(7), 1433-1437 (2006
    • (2006) J. Am. Coll. Cardiol. , vol.48 , Issue.7 , pp. 1433-1437
    • Channick, R.N.1    Olschewski, H.2    Seeger, W.3    Staub, T.4    Voswinckel, R.5    Rubin, L.J.6
  • 54
    • 12244251412 scopus 로고    scopus 로고
    • Efficacy and safety of treprostinil: AN epoprostenol analog for primary pulmonary hypertension
    • Treprostinil Study Group
    • McLaughlin VV, Gaine SP, Barst RJ et al.; Treprostinil Study Group. Efficacy and safety of treprostinil: AN epoprostenol analog for primary pulmonary hypertension. J. Cardiovasc. Pharmacol. 41(2), 293-299 (2003
    • (2003) J. Cardiovasc. Pharmacol. , vol.41 , Issue.2 , pp. 293-299
    • McLaughlin, V.V.1    Gaine, S.P.2    Barst, R.J.3
  • 55
    • 1942443913 scopus 로고    scopus 로고
    • Pharmacokinetics of treprostinil sodium administered by 28-Day chronic continuous subcutaneous infusion
    • Wade M, Baker FJ, Roscigno R et al. Pharmacokinetics of treprostinil sodium administered by 28-Day chronic continuous subcutaneous infusion. J. Clin. Pharmacol. 44(5), 503-509 (2004
    • (2004) J. Clin. Pharmacol. , vol.44 , Issue.5 , pp. 503-509
    • Wade, M.1    Baker, F.J.2    Roscigno, R.3
  • 56
    • 37349045123 scopus 로고    scopus 로고
    • Dose proportionality of treprostinil sodium administered by continuous subcutaneous and intravenous infusion
    • McSwain CS, Benza R, Shapiro S et al. Dose proportionality of treprostinil sodium administered by continuous subcutaneous and intravenous infusion. J. Clin. Pharmacol. 48(1), 19-25 (2008
    • (2008) J. Clin. Pharmacol. , vol.48 , Issue.1 , pp. 19-25
    • McSwain, C.S.1    Benza, R.2    Shapiro, S.3
  • 57
    • 0142074258 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of inhaled iloprost, aerosolized by three different devices, in severe pulmonary hypertension
    • Olschewski H, Rohde B, Behr J et al. Pharmacodynamics and pharmacokinetics of inhaled iloprost, aerosolized by three different devices, in severe pulmonary hypertension. Chest 124(4), 1294-1304 (2003
    • (2003) Chest , vol.124 , Issue.4 , pp. 1294-1304
    • Olschewski, H.1    Rohde, B.2    Behr, J.3
  • 58
    • 33644797883 scopus 로고    scopus 로고
    • Inhaled treprostinil [corrected] for treatment of chronic pulmonary arterial hypertension
    • Voswinckel R, Ghofrani HA, Grimminger F, Seeger W, Olschewski H. Inhaled treprostinil [corrected] for treatment of chronic pulmonary arterial hypertension. Ann. Intern. Med. 144(2), 149-150 (2006
    • (2006) Ann. Intern. Med. , vol.144 , Issue.2 , pp. 149-150
    • Voswinckel, R.1    Ghofrani, H.A.2    Grimminger, F.3    Seeger, W.4    Olschewski, H.5
  • 59
    • 79956139731 scopus 로고    scopus 로고
    • Differential response to intravenous prostacyclin analog therapy in patients with pulmonary arterial hypertension
    • Walkey AJ, Fein D, Horbowicz KJ, Farber HW. Differential response to intravenous prostacyclin analog therapy in patients with pulmonary arterial hypertension. Pulm. Pharmacol. Ther. 24(4), 421-425 (2011
    • (2011) Pulm. Pharmacol. Ther. , vol.24 , Issue.4 , pp. 421-425
    • Walkey, A.J.1    Fein, D.2    Horbowicz, K.J.3    Farber, H.W.4
  • 60
    • 84872204770 scopus 로고    scopus 로고
    • Tyvaso® (treprostinil) inhalation solution, full prescribing information - Revised 2/2011 Silver Spring, MD, USA
    • Tyvaso® (treprostinil) inhalation solution, full prescribing information - Revised 2/2011. United Therapeutics, Silver Spring, MD, USA (2011
    • (2011) United Therapeutics
  • 61
    • 77953795218 scopus 로고    scopus 로고
    • Lack of a pharmacokinetic interaction between oral treprostinil and bosentan in healthy adult volunteers
    • Gotzkowsky SK, Dingemanse J, Lai A, Mottola D, Laliberte K. Lack of a pharmacokinetic interaction between oral treprostinil and bosentan in healthy adult volunteers. J. Clin. Pharmacol. 50(7), 829-834 (2010
    • (2010) J. Clin. Pharmacol. , vol.50 , Issue.7 , pp. 829-834
    • Gotzkowsky, S.K.1    Dingemanse, J.2    Lai, A.3    Mottola, D.4    Laliberte, K.5
  • 62
    • 0038795260 scopus 로고    scopus 로고
    • Effect of continuous subcutaneous treprostinil therapy on the pharmacodynamics and pharmacokinetics of warfarin
    • Wade M, Hunt TL, Lai AA. Effect of continuous subcutaneous treprostinil therapy on the pharmacodynamics and pharmacokinetics of warfarin. J. Cardiovasc. Pharmacol. 41(6), 908-915 (2003
    • (2003) J. Cardiovasc. Pharmacol. , vol.41 , Issue.6 , pp. 908-915
    • Wade, M.1    Hunt, T.L.2    Lai, A.A.3
  • 63
    • 50849116416 scopus 로고    scopus 로고
    • Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension
    • Voswinckel R, Reichenberger F, Enke B et al. Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension. Pulm. Pharmacol. Ther. 21(5), 824-832 (2008
    • (2008) Pulm. Pharmacol. Ther. , vol.21 , Issue.5 , pp. 824-832
    • Voswinckel, R.1    Reichenberger, F.2    Enke, B.3
  • 64
    • 77952301237 scopus 로고    scopus 로고
    • Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: A randomized controlled clinical trial
    • McLaughlin VV, Benza RL, Rubin LJ et al. Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: A randomized controlled clinical trial. J. Am. Coll. Cardiol. 55(18), 1915-1922 (2010
    • (2010) J. Am. Coll. Cardiol. , vol.55 , Issue.18 , pp. 1915-1922
    • McLaughlin, V.V.1    Benza, R.L.2    Rubin, L.J.3
  • 65
    • 80655137697 scopus 로고    scopus 로고
    • Long-Term effects of inhaled treprostinil in patients with pulmonary arterial hypertension: The Treprostinil Sodium Inhalation Used in the Management of Pulmonary Arterial Hypertension (TRIUMPH) study open-Label extension
    • Benza RL, Seeger W, McLaughlin VV et al. Long-Term effects of inhaled treprostinil in patients with pulmonary arterial hypertension: The Treprostinil Sodium Inhalation Used in the Management of Pulmonary Arterial Hypertension (TRIUMPH) study open-Label extension. J. Heart Lung Transplant. 30(12), 1327-1333 (2011
    • (2011) J. Heart Lung Transplant. , vol.30 , Issue.12 , pp. 1327-1333
    • Benza, R.L.1    Seeger, W.2    McLaughlin, V.V.3
  • 66
    • 0012164128 scopus 로고    scopus 로고
    • Food Drug Administration Medical Review - New Drug Application, NDA US FDA, USA
    • Food and Drug Administration. Center for Drug Evaluation and Research. Medical Review - New Drug Application, NDA 22-387. US FDA, USA (2009
    • (2009) Center for Drug Evaluation and Research , pp. 22-387
  • 67
    • 54549125950 scopus 로고    scopus 로고
    • Addition of sildenafil to long-Term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: A randomized trial
    • PACES Study Group
    • Simonneau G, Rubin LJ, Galiè N et al.; PACES Study Group. Addition of sildenafil to long-Term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: A randomized trial. Ann. Intern. Med. 149(8), 521-530 (2008
    • (2008) Ann. Intern. Med. , vol.149 , Issue.8 , pp. 521-530
    • Simonneau, G.1    Rubin, L.J.2    Galiè, N.3
  • 68
    • 77953026428 scopus 로고    scopus 로고
    • Evidence for the use of combination targeted therapeutic approaches for the management of pulmonary arterial hypertension
    • O'Callaghan DS, Savale L, Jais X et al. Evidence for the use of combination targeted therapeutic approaches for the management of pulmonary arterial hypertension. Respir. Med. 104 (Suppl. 1), S74-S80 (2010
    • (2010) Respir. Med. , vol.104 , Issue.SUPPL. 1
    • O'Callaghan, D.S.1    Savale, L.2    Jais, X.3
  • 69
    • 33847368988 scopus 로고    scopus 로고
    • Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension
    • Hoeper MM, Leuchte H, Halank M et al. Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension. Eur. Respir. J. 28(4), 691-694 (2006
    • (2006) Eur. Respir. J. , vol.28 , Issue.4 , pp. 691-694
    • Hoeper, M.M.1    Leuchte, H.2    Halank, M.3
  • 70
    • 70049112901 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of ardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)
    • Galiè N, Hoeper MM, Humbert M et al.; ESC Committee for Practice Guidelines (CPG). Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of ardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur. Heart J. 30(20), 2493-2537 (2009
    • (2009) Eur. Heart J. , vol.30 , Issue.20 , pp. 2493-2537
    • Galiè, N.1    Hoeper, M.M.2    Humbert, M.3
  • 71
    • 0036569119 scopus 로고    scopus 로고
    • Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: A randomized, double-Blind, placebocontrolled trial
    • Arterial Pulmonary Hypertension and Beraprost European (ALPHABET) Study Group
    • Galiè N, Humbert M, Vachiéry JL et al.; Arterial Pulmonary Hypertension and Beraprost European (ALPHABET) Study Group. Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: A randomized, double-Blind, placebocontrolled trial. J. Am. Coll. Cardiol. 39(9), 1496-1502 (2002
    • (2002) J. Am. Coll. Cardiol. , vol.39 , Issue.9 , pp. 1496-1502
    • Galiè, N.1    Humbert, M.2    Vachiéry, J.L.3
  • 72
    • 0038037766 scopus 로고    scopus 로고
    • Beraprost therapy for pulmonary arterial hypertension
    • Beraprost Study Group
    • Barst RJ, McGoon M, McLaughlin V et al.; Beraprost Study Group. Beraprost therapy for pulmonary arterial hypertension. J. Am. Coll. Cardiol. 41(12), 2119-2125 (2003
    • (2003) J. Am. Coll. Cardiol. , vol.41 , Issue.12 , pp. 2119-2125
    • Barst, R.J.1    McGoon, M.2    McLaughlin, V.3
  • 73
    • 84863937744 scopus 로고    scopus 로고
    • Freedom-M: Efficacy and safety of oral treprostinil diethanolamine as monotherapy in patients with pulmonary arterial hypertension
    • abstract 1044
    • Rubin L, Parikh K, Pulido T et al. FREEDOM-M: Efficacy and safety of oral treprostinil diethanolamine as monotherapy in patients with pulmonary arterial hypertension. Chest 140(4), abstract 1044 (2011
    • (2011) Chest , vol.140 , Issue.4
    • Rubin, L.1    Parikh, K.2    Pulido, T.3
  • 74
    • 58349110755 scopus 로고    scopus 로고
    • Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension
    • Voswinckel R, Reichenberger F, Gall H et al. Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension. Pulm. Pharmacol. Ther. 22(1), 50-56 (2009
    • (2009) Pulm. Pharmacol. Ther. , vol.22 , Issue.1 , pp. 50-56
    • Voswinckel, R.1    Reichenberger, F.2    Gall, H.3
  • 75
    • 0032810972 scopus 로고    scopus 로고
    • Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis
    • Olschewski H, Ghofrani A, Walmrath D et al. Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis. Am. J. Respir. Crit. Care Med. 160(2), 600-607 (1999
    • (1999) Am. J. Respir. Crit. Care Med. , vol.160 , Issue.2 , pp. 600-607
    • Olschewski, H.1    Ghofrani, A.2    Walmrath, D.3
  • 76
    • 77951298414 scopus 로고    scopus 로고
    • Iloprost improves gas exchange and exercise tolerance in patients with pulmonary hypertension and chronic obstructive pulmonary disease
    • Dernaika TA, Beavin M, Kinasewitz GT. Iloprost improves gas exchange and exercise tolerance in patients with pulmonary hypertension and chronic obstructive pulmonary disease. Respiration 79(5), 377-382 (2010
    • (2010) Respiration , vol.79 , Issue.5 , pp. 377-382
    • Dernaika, T.A.1    Beavin, M.2    Kinasewitz, G.T.3
  • 77
    • 60249096834 scopus 로고    scopus 로고
    • Sustained improvement with iloprost in a COPD patient with severe pulmonary hypertension
    • Hegewald MJ, Elliott CG. Sustained improvement with iloprost in a COPD patient with severe pulmonary hypertension. Chest 135(2), 536-537 (2009
    • (2009) Chest , vol.135 , Issue.2 , pp. 536-537
    • Hegewald, M.J.1    Elliott, C.G.2
  • 78
    • 4444330401 scopus 로고    scopus 로고
    • Aerosolized iloprost as a bridge to lung transplantation in a patient with cystic fibrosis and pulmonary hypertension
    • Tissières P, Nicod L, Barazzone-Argiroffo C, Rimensberger PC, Beghetti M. Aerosolized iloprost as a bridge to lung transplantation in a patient with cystic fibrosis and pulmonary hypertension. Ann. Thorac. Surg. 78(3), e48-E50 (2004)
    • (2004) Ann. Thorac. Surg. , vol.78 , Issue.3
    • Tissières, P.1    Nicod, L.2    Barazzone-Argiroffo, C.3    Rimensberger, P.C.4    Beghetti, M.5


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