Effects of a stable prostacyclin analogue beraprost sodium on VEGF and PAI-1 gene expression in vascular smooth muscle cells

International Journal of Cardiology

Volumn 132, Issue 3, 2009, Pages 411-418

  Atsuta, Hiroyuki ^a   Uchiyama, Tsuyoshi ^a   Kanai, Hiroyoshi ^a   Iso, Tatsuya ^a   Tanaka, Toru ^a   Suga, Tatsuo ^a   Maeno, Toshitaka ^a   Arai, Masashi ^a   Nagai, Ryozo ^b   Kurabayashi, Masahiko ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Beraprost; PAI 1; SMC; VEGF

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BERAPROST; CALPHOSTIN C; CYCLIC AMP DEPENDENT PROTEIN KINASE; DACTINOMYCIN; KT 5720; LUCIFERASE; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROSTACYCLIN DERIVATIVE; VASCULOTROPIN; WORTMANNIN;

ANIMAL CELL; AORTA; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME ASSAY; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; RABBIT; VASCULAR SMOOTH MUSCLE;

ANIMALS; CELL HYPOXIA; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOTHELIUM, VASCULAR; EPOPROSTENOL; GENE EXPRESSION REGULATION; MYOCYTES, SMOOTH MUSCLE; PLASMINOGEN ACTIVATOR INHIBITOR 1; RABBITS; RATS; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASODILATOR AGENTS;

EID: 60649095647     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2007.12.119     Document Type: Article

References (27)

1. Kobayashi T., Tahara Y., Matsumoto M., et al. Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice. J Clin Invest 114 (2004) 784-794
2. Schwarz U.R., Walter U., and Eigenthaler M. Taming platelets with cyclic nucleotides. Biochem Pharmacol 62 (2001) 1153-1161
3. Kainoh M., Maruyama I., Nishio S., and Nakadate T. Enhancement by beraprost sodium, a stable analogue of prostacyclin, in thrombomodulin expression on membrane surface of cultured vascular endothelial cells via increase in cyclic AMP level. Biochem Pharmacol 41 (1991) 1135-1140
4. McLaughlin V.V., Shillington A., and Rich S. Survival in primary pulmonary hypertension: the impact of epoprostenol therapy. Circulation 106 (2002) 1477-1482
5. Reilly C.F., and McFall R.C. Platelet-derived growth factor and transforming growth factor-beta regulate plasminogen activator inhibitor-1 synthesis in vascular smooth muscle cells. J Biol Chem 266 (1991) 9419-9427
6. Ferrara N., Winer J., and Burton T. Aortic smooth muscle cells express and secrete vascular endothelial growth factor. Growth Factors 5 (1991) 141-148
7. Inoue M., Itoh H., Ueda M., et al. Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions: possible pathophysiological significance of VEGF in progression of atherosclerosis. Circulation 98 (1998) 2108-2116
8. Salame M.Y., Samani N.J., Masood I., and deBono D.P. Expression of the plasminogen activator system in the human vascular wall. Atherosclerosis 152 (2000) 19-28
9. Sasaki Y., and Uchida T. A variant derived from rabbit aortic smooth muscle: phenotype modulation and restoration of smooth muscle characteristics in cells in culture. J Biochem (Tokyo) 106 (1989) 1009-1018
10. Watanabe M., Sakomura Y., Kurabayashi M., et al. Structure and characterization of the 5′-flanking region of the mouse smooth muscle myosin heavy chain (SM1/2) gene. Circ Res 78 (1996) 978-989
11. Taubman M.B., Berk B.C., Izumo S., et al. Angiotensin II induces c-fos mRNA in aortic smooth muscle: role of mobilization and protein kinase C activation. J Biol Chem 264 (1989) 526-530
12. Delaney M.L., and Onderdonk A.B. Evaluation of the AnaeroPack system for growth of clinically significant anaerobes. J Clin Microbiol 35 (1997) 558-562
13. Kamiya T., Kwon A.H., Kanemaki T., et al. A simplified model of hypoxic injury in primary cultured rat hepatocytes. In Vitro Cell Dev Biol Anim 34 (1998) 131-137
14. Uchiyama T., Kurabayashi M., Ohyama Y., et al. Hypoxia induces transcription of the plasminogen activator inhibitor-1 gene through genistein-sensitive tyrosine kinase pathways in vascular endothelial cells. Arterioscler Thromb Vasc Biol 20 (2000) 1155-1161
15. Montminy M. Transcriptional regulation by cyclic AMP. Annu Rev Biochem 66 (1997) 807-822
16. Sassone-Corsi P. Coupling gene expression to cAMP signalling: role of CREB and CREM. Int J Biochem Cell Biol 30 (1998) 27-38
17. Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology 69 Suppl 3 (2005) 4-10
18. Ferrara N. VEGF as a therapeutic target in cancer. Oncology 69 Suppl 3 (2005) 11-16
19. Meyer-Kirchrath J., Debey S., Glandorff C., et al. Gene expression profile of the Gs-coupled prostacyclin receptor in human vascular smooth muscle cells. Biochem Pharmacol 67 (2004) 757-765
20. Niwano K., Arai M., Tomaru K., et al. Transcriptional stimulation of the eNOS gene by the stable prostacyclin analogue beraprost is mediated through cAMP-responsive element in vascular endothelial cells: close link between PGI2 signal and NO pathways. Circ Res 93 (2003) 523-530
21. Levy A.P., Levy N.S., Loscalzo J., et al. Regulation of vascular endothelial growth factor in cardiac myocytes. Circ Res 76 (1995) 758-766
22. Pueyo M.E., Chen Y., D'Angelo G., and Michel J.B. Regulation of vascular endothelial growth factor expression by cAMP in rat aortic smooth muscle cells. Exp Cell Res 238 (1998) 354-358
23. Iimuro S., Shindo T., Moriyama N., et al. Angiogenic effects of adrenomedullin in ischemia and tumor growth. Circ Res 95 (2004) 415-423
24. Peraldi M.N., Rondeau E., Medcalf R.L., et al. Cell-specific regulation of plasminogen activator inhibitor 1 and tissue type plasminogen activator release by human kidney mesangial cells. Biochim Biophys Acta 1134 (1992) 189-196
25. Sugano T., Tsuji H., Masuda H., et al. Adrenomedullin inhibits angiotensin II-induced expression of tissue factor and plasminogen activator inhibitor-1 in cultured rat aortic endothelial cells. Arterioscler Thromb Vasc Biol 21 (2001) 1078-1083
26. Foulkes N.S., Borrelli E., and Sassone-Corsi P. CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64 (1991) 739-749
27. Kietzmann T., Roth U., and Jungermann K. Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes. Blood 94 (1999) 4177-4185