Design of a microfluidic platform for monoclonal antibody extraction using an aqueous two-phase system

Journal of Chromatography A

Volumn 1249, Issue , 2012, Pages 1-7

  Silva, D F C ^a,c   Azevedo, A M ^b,c   Fernandes, P ^b,c   Chu, V ^a   Conde, J P ^a,b   Aires Barros, M R ^b,c  

^a INESC   (Portugal)

^b INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^c Instituto de Biotecnologia e Bioengenharia Lisboa   (Portugal)

Author keywords

Aqueous two phase systems; Microfluidic device; Monoclonal antibodies; Process simulation

Indexed keywords

AQUEOUS TWO PHASE SYSTEM; AUTOIMMUNE DISEASE; BIOPHARMACEUTICALS; BIOPROCESS DESIGN; DIFFERENT STRUCTURE; DOWNSTREAM-PROCESSING; EFFECTIVE TOOL; EXTRACTION YIELD; FLUORESCEIN ISOTHIOCYANATE; IMMUNOGLOBULIN G; LABORATORY TECHNIQUES; MACRO SCALE; MEDICAL TREATMENT; MICRO-FLUIDIC DEVICES; MICRO-SCALES; MICROFLUIDIC PLATFORMS; MONOCLONAL ANTIBODIES (MABS); NEURAL DISORDERS; OPERATION TIME; PDMS MICROFLUIDIC DEVICE; PROCESS SIMULATIONS; SOFT LITHOGRAPHY;

COMPUTER SIMULATION; FLUIDIC DEVICES; FLUORESCENCE MICROSCOPY; GLYCOLS; LITHOGRAPHY; MICROCHANNELS; MICROFLUIDICS; MONOCLONAL ANTIBODIES; OPTIMIZATION; POLYETHYLENE GLYCOLS; SODIUM CHLORIDE; SURFACE PLASMON RESONANCE;

DISEASES;

FLUORESCEIN ISOTHIOCYANATE; IMMUNOGLOBULIN G; MACROGOL; PHOSPHATE; SODIUM CHLORIDE;

AQUEOUS TWO PHASE SYSTEM; ARTICLE; DIFFUSION; DRUG ISOLATION; EQUIPMENT DESIGN; EXTRACTION; FLOW RATE; FLUORESCENCE MICROSCOPY; INTERMETHOD COMPARISON; MICROFLUIDICS; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SEPARATION TECHNIQUE;

ANTIBODIES, MONOCLONAL; EQUIPMENT DESIGN; MICROFLUIDICS;

EID: 84863784327     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.05.089     Document Type: Article

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