Novel thermal-sensitive hydrogel enhances both humoral and cell-mediated immune responses by intranasal vaccine delivery

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 81, Issue 3, 2012, Pages 486-497

  Wu, Youbin ^a,b   Wu, Shipo ^c   Hou, Lihua ^c   Wei, Wei ^a   Zhou, Meng ^a   Su, Zhiguo ^a   Wu, Jie ^a   Chen, Wei ^c   Ma, Guanghui ^a  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Ebola; Hydrogel; Mucosal immunization; Quarternized chitosan; Thermal sensitive; Vaccine delivery

Indexed keywords

ADENOVIRUS VECTOR; ALPHA,BETA GLYCEROPHOSPHATE; CHITOSAN DERIVATIVE; EBOLA VACCINE; GAMMA INTERFERON; GLYCEROPHOSPHATE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 2; N [(2 HYDROXY 3 TRIMETHYLAMMONIUM)PROPYL]CHITOSAN CHLORIDE; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG FORMULATION; EBOLA VIRUS; FEMALE; FLOW KINETICS; HEAT SENSITIVITY; HUMORAL IMMUNITY; HYDROGEL; IMMUNIZATION; MOUSE; NONHUMAN; SPLEEN CELL; TH1 CELL; TH2 CELL;

ADENOVIRIDAE; ADMINISTRATION, INTRANASAL; ANIMALS; ANTIGENS, VIRAL; CHITOSAN; CYTOKINES; EBOLA VACCINES; FEMALE; GLYCEROPHOSPHATES; HYDROGELS; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; TEMPERATURE; TH1 CELLS; TIME FACTORS; VIRAL ENVELOPE PROTEINS;

EID: 84863782097     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.03.021     Document Type: Article

References (38)

1. J. Holmgren, C. Czerkinsky, Mucosal immunity and vaccines, Nat. Med. 11 (2005) S45-S53. (Pubitemid 40562303)
2. M.R. Neutra, P.A. Kozlowski, Mucosal vaccines: the promise and the challenge, Nat. Rev. Immunol. 6 (2006) 148-158. (Pubitemid 43361590)
3. + T cells in the genital and intestinal tracts, Vaccine 28 (2010) 1226-1233.
4. S.S. Davis, Nasal vaccines, Adv. Drug Deliv. Rev. 51 (2001) 21-42. (Pubitemid 32763070)
5. S.S. Davis, L. Illum, Absorption enhancers for nasal drug delivery, Clin. Pharmacokinet. 42 (2003) 1107-1128. (Pubitemid 37357648)
6. R.J. Soane, M. Frier, A.C. Perkins, N.S. Jones, S.S. Davis, L. Illum, Evaluation of the clearance characteristics of bioadhesive systems in humans, Int. J. Pharm. 178 (1999) 55-65. (Pubitemid 29074407)
7. Z. Sui, Q. Chen, F. Fang, M. Zheng, Z. Chen, Cross-protection against influenza virus infection by intranasal administration of M1-based vaccine with chitosan as an adjuvant, Vaccine 28 (2010) 7690-7698.
8. M. Amidi, S.G. Romeijn, J.C. Verhoef, H.E. Junginger, L. Bungener, A. Huckriede, D.J.A. Crommelin, W. Jiskoot, N-Trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: Biological properties and immunogenicity in a mouse model, Vaccine 25 (2007) 144-153. (Pubitemid 44855251)
9. N. Hagenaars, M. Mania, P. de Jong, I. Que, R. Nieuwland, B. Slutter, H. Glansbeek, J. Heldens, H. van den Bosch, C. Lowik, E. Kaijzel, E. Mastrobattista, W. Jiskoot, Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine, J. Control. Release 144 (2010) 17-24.
10. L. Illum, I. Jabbal-Gill, M. Hinchcliffe, A.N. Fisher, S.S. Davis, Chitosan as a novel nasal delivery system for vaccines, Adv. Drug Deliv. Rev. 51 (2001) 81-96. (Pubitemid 32763074)
11. D.A. Zaharoff, C.J. Rogers, K.W. Hance, J. Schlom, J.W. Greiner, Chitosan solution enhances both humoral and cell-mediated immune responses to subcutaneous vaccination, Vaccine 25 (2007) 2085-2094. (Pubitemid 46227669)
12. T. Nagamoto, Y. Hattori, K. Takayama, Y. Maitani, Novel chitosan particles and chitosan-coated emulsions inducing immune response via intranasal vaccine delivery, Pharm. Res. 21 (2004) 671-674. (Pubitemid 38457290)
13. A. Alhalaweh, S. Andersson, S.P. Velaga, Preparation of zolmitriptan-chitosan microparticles by spray drying for nasal delivery, Eur. J. Pharm. Sci. 38 (2009) 206-214.
14. J. Wu, W. Wei, L.Y. Wang, Z.G. Su, G.H. Ma, A thermosensitive hydrogel based on quaternized chitosan and poly(ethylene glycol) for nasal drug delivery system, Biomaterials 28 (2007) 2220-2232. (Pubitemid 46216447)
15. H. Feldmann, T.W. Geisbert, Ebola haemorrhagic fever, Lancet 377 (2011) 849-862.
16. N.K. Jaax, K.J. Davis, T.J. Geisbert, P. Vogel, G.P. Jaax, M. Topper, P.B. Jahrling, Lethal experimental infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure, Arch. Pathol. Lab. Med. 120 (1996) 140-155. (Pubitemid 26058522)
17. E. Johnson, N. Jaax, J. White, P. Jahrling, Lethal experimental infections of rhesus monkeys by aerosolized Ebola virus, Int. J. Exp. Pathol. 76 (1995) 227-236.
18. G.P. Kobinger, H. Feldmann, Y. Zhi, G. Schumer, G. Gao, F. Feldmann, S. Jones, J.M. Wilson, Chimpanzee adenovirus vaccine protects against Zaire Ebola virus, Virology 346 (2006) 394-401. (Pubitemid 43357883)
19. F.W.H.M. Merkus, N.G.M. Schipper, W.A.J.J. Hermens, S.G. Romeijn, J.C. Verhoef, Absorption enhancers in nasal drug delivery: efficacy and safety, J. Control. Release 24 (1993) 201-208. (Pubitemid 23161332)
20. M.A. Croyle, A. Patel, K.N. Tran, M. Gray, Y. Zhang, J.E. Strong, H. Feldmann, G.P. Kobinger, Nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice, PLoS One 3 (2008) e3548.
21. M. Santosuosso, S. McCormick, Z. Xing, Adenoviral vectors for mucosal vaccination against infectious diseases, Viral Immunol. 18 (2005) 283-291. (Pubitemid 41106007)
22. N.J. Sullivan, A. Sanchez, P.E. Rollin, Z.Y. Yang, G.J. Nabel, Development of a preventive vaccine for Ebola virus infection in primates, Nature 408 (2000) 605-609.
23. J. Wu, Z.G. Su, G.H. Ma, A thermo- and pH-sensitive hydrogel composed of quaternized chitosan/glycerophosphate, Int. J. Pharm. 315 (2006) 1-11. (Pubitemid 43674112)
24. N. Hagenaars, E. Mastrobattista, R.J. Verheul, I. Mooren, H.L. Glansbeek, J.G. Heldens, H. van den Bosch, W. Jiskoot, Physicochemical and immunological characterization of N,N,N-trimethyl chitosan-coated whole inactivated influenza virus vaccine for intranasal administration, Pharm. Res. 26 (2009) 1353-1364.
25. E. Greenbaum, A. Furst, A. Kiderman, B. Stewart, R. Levy, M. Schlesinger, A. Morag, Z. Zakay-Rones, Mucosal [SIgA] and serum [IgG] immunologic responses in the community after a single intra-nasal immunization with a new inactivated trivalent influenza vaccine, Vaccine 20 (2002) 1232-1239. (Pubitemid 34135961)
26. W. Xu, Y. Shen, Z.G. Jiang, Y. Wang, Y.W. Chu, S.D. Xiong, Intranasal delivery of chitosan-DNA vaccine generates mucosal SIgA and anti-CVB3 protection, Vaccine 22 (2004) 3603-3612. (Pubitemid 39099636)
27. E. Greenbaum, D. Engelhard, R. Levy, M. Schlezinger, A. Morag, Z. Zakay-Rones, Mucosal (SIgA) and serum (IgG) immunologic responses in young adults following intranasal administration of one or two doses of inactivated, trivalent anti-influenza vaccine, Vaccine 22 (2004) 2566-2577. (Pubitemid 38757360)
28. R.F. Gill, G. Pirockinaite, N.L. O'Sullivan, P.C. Montgomery, Nasal-associated lymphoid tissue is not an absolute requirement for the induction of rat tear IgA antibody responses, Curr. Eye Res. 35 (2010) 1-8.
29. A.B. Hutchings, A. Helander, K.J. Silvey, K. Chandran, W.T. Lucas, M.L. Nibert, M.R. Neutra, Secretory immunoglobulin A antibodies against the sigma1 outer capsid protein of reovirus type 1 Lang prevent infection of mouse Peyer's patches, J. Virol. 78 (2004) 947-957. (Pubitemid 38067616)
30. F. Esmaeili, S. Heuking, H.E. Junginger, G. Borchard, Progress in chitosan-based vaccine delivery systems, J. Drug Deliv. Sci. Technol. 20 (2010) 53-61.
31. M. Amidi, S.G. Romeijn, G. Borchard, H.E. Junginger, W.E. Hennink, W. Jiskoot, Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system, J. Control. Release 111 (2006) 107-116. (Pubitemid 43290000)
32. Y.H. Lin, F.L. Mi, C.T. Chen, W.C. Chang, S.F. Peng, H.F. Liang, H.W. Sung, Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery, Biomacromolecules 8 (2007) 146-152.
33. C.L. Densmore, Polyethyleneimine-based gene therapy by inhalation, Expert Opin. Biol. Ther. 3 (2003) 1083-1092. (Pubitemid 37295764)
34. Y. Pan, Y.J. Li, H.Y. Zhao, J.M. Zheng, H. Xu, G. Wei, J.S. Hao, F.D. Cui, Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo, Int. J. Pharm. 249 (2002) 139-147. (Pubitemid 35333440)
35. R.C. Read, S.C. Naylor, C.W. Potter, J. Bond, I. Jabbal-Gill, A. Fisher, L. Illum, R. Jennings, Effective nasal influenza vaccine delivery using chitosan, Vaccine 23 (2005) 4367-4374. (Pubitemid 40991223)
36. M.K. Yoo, S.K. Kang, J.H. Choi, I.K. Park, H.S. Na, H.C. Lee, E.B. Kim, N.K. Lee, J.W. Nah, Y.J. Choi, C.S. Cho, Targeted delivery of chitosan nanoparticles to Peyer's patch using M cell-homing peptide selected by phage display technique, Biomaterials 31 (2010) 7738-7747.
37. M. Pizza, M.M. Giuliani, M.R. Fontana, E. Monaci, G. Douce, G. Dougan, K.H. Mills, R. Rappuoli, G. Del Giudice, Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants, Vaccine 19 (2001) 2534-2541. (Pubitemid 32234269)
38. H.O. Alpar, S. Somavarapu, K.N. Atuah, V.W. Bramwell, Biodegradable mucoadhesive particulates for nasal and pulmonary antigen and DNA delivery, Adv. Drug Deliv. Rev. 57 (2005) 411-430. (Pubitemid 39550968)