Design and synthesis of cleavable biotinylated dideoxynucleotides for DNA sequencing by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Analytical Biochemistry

Volumn 427, Issue 2, 2012, Pages 193-201

  Qiu, Chunmei ^a,b   Kumar, Shiv ^a,b   Guo, Jia ^a,b   Yu, Lin ^a,b   Guo, Wenjing ^a,b   Shi, Shundi ^a,b   Russo, James J ^a,b   Ju, Jingyue ^a,b  

^a College of Physicians and Surgeons ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Cleavable biotinylated nucleotides; DNA sequencing; MALDI TOF MS; Solid phase capture

Indexed keywords

COENZYMES; DESORPTION; DNA; DNA SEQUENCES; GENE ENCODING; INDUCTIVELY COUPLED PLASMA; MASS SPECTROMETRY; NUCLEOTIDES; PHOSPHORUS COMPOUNDS;

DNA SEQUENCING; MALDI TOF MS; MALDI-TOF-MS ANALYSIS; MATRIX-ASSISTED LASER DESORPTION/IONIZATION-TIME-OF-FLIGHT MASS SPECTROMETRY; MODIFIED NUCLEOTIDES; SANGER SEQUENCING; SOLID-PHASE; TRIS(2 CARBOXYETHYL)PHOSPHINE;

POLYMERASE CHAIN REACTION;

ADENOSINE TRIPHOSPHATE DERIVATIVE; AZIDE; BIOTIN DERIVATIVE; CYTIDINE TRIPHOSPHATE; DIDEOXYNUCLEOTIDE; DNA FRAGMENT; DNA POLYMERASE; GUANOSINE TRIPHOSPHATE DERIVATIVE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; STREPTAVIDIN; SYNTHETIC DNA; TRIS(2 CARBOXYETHYL)PHOSPHINE; URIDINE TRIPHOSPHATE;

ANALYTIC METHOD; AQUEOUS SOLUTION; ARTICLE; BIOTINYLATION; CHEMICAL REACTION; DNA SEQUENCE; DNA STRAND; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SANGER SEQUENCING REACTION; SYNTHESIS;

EID: 84863777385     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2012.04.021     Document Type: Article

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