Heritability of functioning in families with schizophrenia in relation to neurocognition

Schizophrenia Research

Volumn 139, Issue 1-3, 2012, Pages 105-109

  Savage, R M ^a   Wiener, H W ^b   Nimgaonkar, V ^c   Devlin, B ^c   Calkins, M E ^d   Gur, R E ^d   O'Jile, J ^e   Bradford, L D ^f   Edwards, N ^g   Kwentus, J ^e   Allen, T ^h   McEvoy, J P ^h   Nasrallah, H ⁱ   Santos, A B ^j   Aduroja, T ^a   Lahti, A ^a   May, R S ^a   Montgomery Barefield, L ^a   Go, R C P ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^f MOREHOUSE SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^h DUKE UNIVERSITY MEDICAL CENTER   (United States)

ⁱ UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^j MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

more..

Author keywords

Families; Heritability; Neurocognition

Indexed keywords

ADOLESCENT; ADULT; AFRICAN AMERICAN; AGE; AGED; ARTICLE; COGNITION; DEMOGRAPHY; EMPLOYMENT; FAMILY FUNCTIONING; FEMALE; GENDER; GLOBAL ASSESSMENT SCALE; HERITABILITY; HUMAN; LIFE EVENT; MAJOR CLINICAL STUDY; MALE; MARRIAGE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; RATING SCALE; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCORING SYSTEM;

ACTIVITIES OF DAILY LIVING; ADOLESCENT; ADULT; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; COGNITION DISORDERS; EMPLOYMENT; FACTOR ANALYSIS, STATISTICAL; FAMILY HEALTH; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PHENOTYPE; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84863776775     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2012.04.015     Document Type: Article

References (38)

1. Albert M.S., Jones K., Savage C.R., Berkman L., Seeman T., Blazer D., Rowe J.W. Predictors of cognitive change in older persons: MacArthur studies of successful aging. Psychol. Aging 1995, 10(4):578-589.
2. Aliyu M.H., Calkins M.E., Swanson C.L., Lyons P.D., Savage R.M., May R., Wiener H., McLeod-Bryant S., Nimgaonkar V.L., Ragland J.D., Gur R.E., Gur R.C., Bradford L.D., Edwards N., Kwentus J., McEvoy J.P., Santos A.B., McCleod-Bryant S., Tennison C., Go R.C., Allen T.B. Project among African-Americans to explore risks for schizophrenia (PAARTNERS): recruitment and assessment methods. Schizophr. Res. 2006, 87(1-3):32-44.
3. Almasy L., Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet. 1998, 62(5):1198-1211.
4. American Psychiatric Association Diagnostic and Statisticl Manual of Mental Disorders 2000, American Psychiatric Association, Washington, DC, Text Revision. Fourth edition.
5. Anthony W.A. The Principles of Psychiatric Rehabilitation 1978, Human Resources Development Press, Amherst, Mass.
6. Anthony W.A. Psychiatric Rehabilitation 2002, Center for Psychiatric Rehabilitation, Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, MA. second ed.
7. Bottlender R., Strauss A., Moller H.J. Social disability in schizophrenic, schizoaffective and affective disorders 15years after first admission. Schizophr. Res. 2010, 116(1):9-15.
8. Bowie C.R., Reichenberg A., Patterson T.L., Heaton R.K., Harvey P.D. Determinants of real-world functional performance in schizophrenia subjects: correlations with cognition, functional capacity, and symptoms. Am. J. Psychiatry 2006, 163(3):418-425.
9. Bowie C.R., Leung W.W., Reichenberg A., McClure M.M., Patterson T.L., Heaton R.K., Harvey P.D. Predicting schizophrenia patients' real-world behavior with specific neuropsychological and functional capacity measures. Biol. Psychiatry 2008, 63(5):505-511.
10. Cadenhead K.S., Braff D.L. Endophenotyping schizotypy: a prelude to genetic studies within the schizophrenia spectrum. Schizophr. Res. 2002, 54(1-2):47-57.
11. Calkins M.E., Curtis C.E., Iacono W.G., Grove W.M. Antisaccade performance is impaired in medically and psychiatrically healthy biological relatives of schizophrenia patients. Schizophr. Res. 2004, 71(1):167-178.
12. Calkins M.E., Tepper P., Gur R.C., Ragland J.D., Klei L., Wiener H.W., Richard J., Savage R.M., Allen T.B., O'Jile J., Devlin B., Kwentus J., Aliyu M.H., Bradford L.D., Edwards N., Lyons P.D., Nimgaonkar V.L., Santos A.B., Go R.C., Gur R.E. Project among African-Americans to explore risks for schizophrenia (PAARTNERS): evidence for impairment and heritability of neurocognitive functioning in families of schizophrenia patients. Am. J. Psychiatry 2010, 167(4):459-472.
13. Camisa K.M., Bockbrader M.A., Lysaker P., Rae L.L., Brenner C.A., O'Donnell B.F. Personality traits in schizophrenia and related personality disorders. Psychiatry Res. 2005, 133(1):23-33.
14. Endicott J., Spitzer R.L., Fleiss J.L., Cohen J. The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance. Arch. Gen. Psychiatry 1976, 33(6):766-771.
15. Green M.F. What are the functional consequences of neurocognitive deficits in schizophrenia?. Am. J. Psychiatry 1996, 153(3):321-330.
16. Green M.F., Kern R.S., Braff D.L., Mintz J. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the "right stuff"?. Schizophr. Bull. 2000, 26(1):119-136.
17. Greenwood T.A., Braff D.L., Light G.A., Cadenhead K.S., Calkins M.E., Dobie D.J., Freedman R., Green M.F., Gur R.E., Gur R.C., Mintz J., Nuechterlein K.H., Olincy A., Radant A.D., Seidman L.J., Siever L.J., Silverman J.M., Stone W.S., Swerdlow N.R., Tsuang D.W., Tsuang M.T., Turetsky B.I., Schork N.J. Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia. Arch. Gen. Psychiatry 2007, 64(11):1242-1250.
18. Guo X., Zhai J., Liu Z., Fang M., Wang B., Wang C., Hu B., Sun X., Lv L., Lu Z., Ma C., He X., Guo T., Xie S., Wu R., Xue Z., Chen J., Twamley E.W., Jin H., Zhao J. Effect of antipsychotic medication alone vs combined with psychosocial intervention on outcomes of early-stage schizophrenia: a randomized, 1-year study. Arch. Gen. Psychiatry 2010, 67(9):895-904.
19. Gur R.C., Ragland J.D., Moberg P.J., Turner T.H., Bilker W.B., Kohler C., Siegel S.J., Gur R.E. Computerized neurocognitive scanning: I. Methodology and validation in healthy people. Neuropsychopharmacology 2001, 25(5):766-776.
20. Gur R.E., Nimgaonkar V.L., Almasy L., Calkins M.E., Ragland J.D., Pogue-Geile M.F., Kanes S., Blangero J., Gur R.C. Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia. Am. J. Psychiatry 2007, 164(5):813-819.
21. Gur R.C., Richard J., Hughett P., Calkins M.E., Macy L., Bilker W.B., Brensinger C., Gur R.E. A cognitive neuroscience-based computerized battery for efficient measurement of individual differences: standardization and initial construct validation. J. Neurosci. Methods 2010, 187(2):254-262.
22. Harvey P.D., McClure M.M., Patterson T.L., McGrath J.A., A, E.P., Bowie C.R., Siever L.J. Impairment in functional capacity as an endophenotype candidate in severe mental illness. Schizophr. Bull. 2011, (First published online: May 11, 2011). 10.1093/schbul/sbr046.
23. Hollingshead A.B. Four Factor Index of Social Status 1975, Yale Univeristy Press, New Haven, Conn.
24. Kahn R.S., Fleischhacker W.W., Boter H., Davidson M., Vergouwe Y., Keet I.P., Gheorghe M.D., Rybakowski J.K., Galderisi S., Libiger J., Hummer M., Dollfus S., Lopez-Ibor J.J., Hranov L.G., Gaebel W., Peuskens J., Lindefors N., Riecher-Rossler A., Grobbee D.E. Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial. Lancet 2008, 371(9618):1085-1097.
25. Kendler K.S., McGuire M., Gruenberg A.M., Walsh D. Schizotypal symptoms and signs in the Roscommon Family Study their factor structure and familial relationship with psychotic and affective disorders. Arch. Gen. Psychiatry 1995, 52(4):296-303.
26. Leifker F.R., Bowie C.R., Harvey P.D. Determinants of everyday outcomes in schizophrenia: the influences of cognitive impairment, functional capacity, and symptoms. Schizophr. Res. 2009, 115(1):82-87.
27. Levy D.L., H.P.S., Matthysse S., Mendell N.R. Eye tracking dysfunction and schizophrenia: a critical perspective. Schizophr. Bull. 1993, 19:461-505.
28. Lieberman J.A., Stroup T.S., McEvoy J.P., Swartz M.S., Rosenheck R.A., Perkins D.O., Keefe R.S., Davis S.M., Davis C.E., Lebowitz B.D., Severe J., Hsiao J.K. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N. Engl. J. Med. 2005, 353(12):1209-1223.
29. Mausbach B.T., Bowie C.R., Harvey P.D., Twamley E.W., Goldman S.R., Jeste D.V., Patterson T.L. Usefulness of the UCSD performance-based skills assessment (UPSA) for predicting residential independence in patients with chronic schizophrenia. J. Psychiatr. Res. 2008, 42(4):320-327.
30. Mausbach B.T., Moore R., Bowie C., Cardenas V., Patterson T.L. A review of instruments for measuring functional recovery in those diagnosed with psychosis. Schizophr. Bull. 2009, 35(2):307-318.
31. McGrath J.A., Avramopoulos D., Lasseter V.K., Wolyniec P.S., Fallin M.D., Liang K.Y., Nestadt G., Thornquist M.H., Luke J.R., Chen P.L., Valle D., Pulver A.E. Familiality of novel factorial dimensions of schizophrenia. Arch. Gen. Psychiatry 2009, 66(6):591-600.
32. Milev P., Ho B.C., Arndt S., Andreasen N.C. Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-up. Am. J. Psychiatry 2005, 162(3):495-506.
33. Nurnberger J.I., Blehar M.C., Kaufmann C.A., York-Cooler C., Simpson S.G., Harkavy-Friedman J., Severe J.B., Malaspina D., Reich T. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch. Gen. Psychiatry 1994, 51(11):849-859. (discussion 863-844).
34. Radant A.D., Hommer D.W. A quantitative analysis of saccades and smooth pursuit during visual pursuit tracking. A comparison of schizophrenics with normals and substance abusing controls. Schizophr. Res. 1992, 6(3):225-235.
35. Vassos E., Sham P.C., Cai G., Deng H., Liu X., Sun X., Zhao J., Murray R.M., Collier D.A., Li T. Correlation and familial aggregation of dimensions of psychosis in affected sibling pairs from China. Br. J. Psychiatry 2008, 193(4):305-310.
36. Wiener H., Klei L., Calkins M., Wood J., Nimgaonkar V., Gur R.C., Bradford L.D., Richard J., Edwards N., Savage R., Kwentus J., Allen T., McEvoy J., Santos A., Gur R.E., Devlin B., Go R. Schizophr. Bull. 2012, (Jan 10, Electronic publication ahead of print).
37. http://www.nationaloutcomemeasures.samhsa.gov/.
38. http://www.nrepp.samhsa.gov.