Human Nanog pseudogene8 promotes the proliferation of gastrointestinal cancer cells

Experimental Cell Research

Volumn 318, Issue 15, 2012, Pages 1799-1807

  Uchino, Keita ^a   Hirano, Gen ^a   Hirahashi, Minako ^a   Isobe, Taichi ^a   Shirakawa, Tsuyoshi ^a   Kusaba, Hitoshi ^a   Baba, Eishi ^a   Tsuneyoshi, Masazumi ^a   Akashi, Koichi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Cancer stem cells; Gastrointestinal cancer; Nanog; Nanog P8; Proliferation

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; COMPLEMENTARY DNA; KI 67 ANTIGEN; LEFT RIGHT DETERMINATION FACTOR; MULTIDRUG RESISTANCE PROTEIN 1; OCTAMER TRANSCRIPTION FACTOR 4; SMALL INTERFERING RNA; STAT3 PROTEIN; TRANSCRIPTION FACTOR HESX1; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; VERAPAMIL;

ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER LOCALIZATION; CARCINOGENESIS; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOGENE; PSEUDOGENE 8; SIDE POPULATION CELL;

EID: 84863775405     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2012.04.011     Document Type: Article

References (27)

1. Bonnet D., Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997, 3:730-737.
2. Al-Hajj M., Wicha M.S., Benito-Hernandez A., Morrison S.J., Clarke M.F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U S A 2003, 100:3983-3988.
3. Singh S.K., Hawkins C., Clarke I.D., Squire J.A., Bayani J., Hide T., Henkelman R.M., Cusimano M.D., Dirks P.B. Identification of human brain tumour initiating cells. Nature 2004, 432:396-401.
4. Haraguchi N., Utsunomiya T., Inoue H., Tanaka F., Mimori K., Barnard G.F., Mori M. Characterization of a side population of cancer cells from human gastrointestinal system. Stem Cells 2006, 24:506-513.
5. Chambers I., Colby D., Robertson M., Nichols J., Lee S., Tweedie S., Smith A. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003, 113:643-655.
6. Mitsui K., Tokuzawa Y., Itoh H., Segawa K., Murakami M., Takahashi K., Maruyama M., Maeda M., Yamanaka S. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 2003, 113:631-642.
7. Darr H., Mayshar Y., Benvenisty N. Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features. Development 2006, 133:1193-1201.
8. Yasuda S.Y., Tsuneyoshi N., Sumi T., Hasegawa K., Tada T., Nakatsuji N., Suemori H. NANOG maintains self-renewal of primate ES cells in the absence of a feeder layer. Genes Cells 2006, 11:1115-1123.
9. Clark A.T., Rodriguez R.T., Bodnar M.S., Abeyta M.J., Cedars M.I., Turek P.J., Firpo M.T., Reijo Pera R.A. Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. Stem Cells 2004, 22:169-179.
10. Ezeh U.I., Turek P.J., Reijo R.A., Clark A.T. Human embryonic stem cell genes OCT4, NANOG STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer 2005, 104:2255-2265.
11. Hoei-Hansen C.E., Almstrup K., Nielsen J.E., Brask Sonne S., Graem N., Skakkebaek N.E., Leffers H., Rajpert-De Meyts E. Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours. Histopathology 2005, 47:48-56.
12. Gu G., Yuan J., Wills M., Kasper S. Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo. Cancer Res. 2007, 67:4807-4815.
13. Hoei-Hansen C.E., Kraggerud S.M., Abeler V.M., Kaern J., Rajpert-De Meyts E., Lothe R.A. Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers. Mol. Cancer 2007, 6:12.
14. Santagata S., Ligon K.L., Hornick J.L. Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors. Am. J. Surg. Pathol. 2007, 31:836-845.
15. Bussolati B., Bruno S., Grange C., Ferrando U., Camussi G. Identification of a tumor-initiating stem cell population in human renal carcinomas. FASEB J. 2008, 22:3696-3705.
16. Chiou S.H., Yu C.C., Huang C.Y., Lin S.C., Liu C.J., Tsai T.H., Chou S.H., Chien C.S., Ku H.H., Lo J.F. Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. Clin. Cancer Res. 2008, 14:4085-4095.
17. Ye F., Zhou C., Cheng Q., Shen J., Chen H. Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells. BMC Cancer 2008, 8:108.
18. Zhang S., Balch C., Chan M.W., Lai H.C., Matei D., Schilder J.M., Yan P.S., Huang T.H., Nephew K.P. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res. 2008, 68:4311-4320.
19. Booth H.A., Holland P.W. Eleven daughters of NANOG. Genomics 2004, 84:229-238.
20. I. Eberle, B. Pless, M. Braun, T. Dingermann, R. Marschalek, Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells, Nucleic Acids Res. 38 5384-5395.
21. Hart A.H., Hartley L., Parker K., Ibrahim M., Looijenga L.H., Pauchnik M., Chow C.W., Robb L. The pluripotency homeobox gene NANOG is expressed in human germ cell tumors. Cancer 2005, 104:2092-2098.
22. Kim J.S., Kim J., Kim B.S., Chung H.Y., Lee Y.Y., Park C.S., Lee Y.S., Lee Y.H., Chung I.Y. Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog. Exp. Mol. Med. 2005, 37:601-607.
23. Inoda S., Hirohashi Y., Torigoe T., Morita R., Takahashi A., Asanuma H., Nakatsugawa M., Nishizawa S., Tamura Y., Tsuruma T., Terui T., Kondo T., Ishitani K., Hasegawa T., Hirata K., Sato N. Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells. Am. J. Pathol 2011, 178:1805-1813.
24. Wang Q., He W., Lu C., Wang Z., Wang J., Giercksky K.E., Nesland J.M., Suo Z. Oct3/4 and Sox2 are significantly associated with an unfavorable clinical outcome in human esophageal squamous cell carcinoma. Anticancer Res. 2009, 29:1233-1241.
25. Schoenhals M., Kassambara A., De Vos J., Hose D., Moreaux J., Klein B. Embryonic stem cell markers expression in cancers. Biochem. Biophys. Res. Commun. 2009, 383:157-162.
26. Jeter C.R., Badeaux M., Choy G., Chandra D., Patrawala L., Liu C., Calhoun-Davis T., Zaehres H., Daley G.Q., Tang D.G. Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells 2009, 27:993-1005.
27. Kuroda T., Tada M., Kubota H., Kimura H., Hatano S.Y., Suemori H., Nakatsuji N., Tada T. Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol. Cell Biol. 2005, 25:2475-2485.