메뉴 건너뛰기




Volumn 142, Issue JUNE, 2012, Pages

Application of personalised medicine to solid tumours: Opportunities and challenges

Author keywords

Array CGH; Cancer genomics; Genomic aberrations; Personalised medicine; Sequencing

Indexed keywords

B RAF KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; RAF PROTEIN; RAS PROTEIN; SCATTER FACTOR RECEPTOR; STEM CELL FACTOR; TRANSCRIPTOME; VASCULOTROPIN; BIOLOGICAL MARKER;

EID: 84863768445     PISSN: 14247860     EISSN: None     Source Type: Journal    
DOI: 10.4414/smw.2012.13587     Document Type: Review
Times cited : (10)

References (54)
  • 3
    • 79959991704 scopus 로고    scopus 로고
    • Current status of genome-wide association studies in cancer
    • Epub 2011/06/17
    • Chung CC, Chanock SJ. Current status of genome-wide association studies in cancer. Hum Genet. 2011;130(1):59-78. Epub 2011/06/17.
    • (2011) Hum Genet , vol.130 , Issue.1 , pp. 59-78
    • Chung, C.C.1    Chanock, S.J.2
  • 4
    • 80655148792 scopus 로고    scopus 로고
    • Genetic polymorphisms of GSTP1 and XRCC1: Prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC) patients
    • Epub 2011/10/20
    • Zhou F, Yu Z, Jiang T, Lv H, Yao R, Liang J. Genetic polymorphisms of GSTP1 and XRCC1: prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Swiss Med Wkly. 2011;141:w13275. Epub 2011/10/20.
    • (2011) Swiss Med Wkly , vol.141
    • Zhou, F.1    Yu, Z.2    Jiang, T.3    Lv, H.4    Yao, R.5    Liang, J.6
  • 6
    • 40049098166 scopus 로고    scopus 로고
    • Cumulative association of five genetic variants with prostate cancer
    • Epub 2008/01/18
    • Zheng SL, Sun J, Wiklund F, Smith S, Stattin P, Li G, et al. Cumulative association of five genetic variants with prostate cancer. N Engl J Med. 2008;358(9):910-9. Epub 2008/01/18.
    • (2008) N Engl J Med , vol.358 , Issue.9 , pp. 910-919
    • Zheng, S.L.1    Sun, J.2    Wiklund, F.3    Smith, S.4    Stattin, P.5    Li, G.6
  • 7
    • 58149333712 scopus 로고    scopus 로고
    • Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: A population-based study
    • Epub 2008/08/13
    • van Hoek M, Dehghan A, Witteman JC, van Duijn CM, Uitterlinden AG, Oostra BA, et al. Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. Diabetes. 2008;57(11):3122-8. Epub 2008/08/13.
    • (2008) Diabetes , vol.57 , Issue.11 , pp. 3122-3128
    • Van Hoek, M.1    Dehghan, A.2    Witteman, J.C.3    Van Duijn, C.M.4    Uitterlinden, A.G.5    Oostra, B.A.6
  • 9
    • 34547618083 scopus 로고    scopus 로고
    • Drinking from the fire hose - Statistical issues in genomewide association studies
    • Epub 2007/07/20
    • Hunter DJ, Kraft P. Drinking from the fire hose - statistical issues in genomewide association studies. N Engl J Med. 2007;357(5):436-9. Epub 2007/07/20.
    • (2007) N Engl J Med , vol.357 , Issue.5 , pp. 436-439
    • Hunter, D.J.1    Kraft, P.2
  • 10
    • 29544447266 scopus 로고    scopus 로고
    • The AmpliChip CYP450 genotyping test: Integrating a new clinical tool
    • Epub 2006/06/15
    • de Leon J, Susce MT, Murray-Carmichael E. The AmpliChip CYP450 genotyping test: Integrating a new clinical tool. Mol Diagn Ther. 2006;10(3):135-51. Epub 2006/06/15.
    • (2006) Mol Diagn Ther , vol.10 , Issue.3 , pp. 135-151
    • De Leon, J.1    Susce, M.T.2    Murray-Carmichael, E.3
  • 11
    • 77955654135 scopus 로고    scopus 로고
    • Expectations, validity, and reality in gene expression profiling
    • Epub 2010/06/29
    • Kim K, Zakharkin SO, Allison DB. Expectations, validity, and reality in gene expression profiling. J Clin Epidemiol. 2010;63(9):950-9. Epub 2010/06/29.
    • (2010) J Clin Epidemiol , vol.63 , Issue.9 , pp. 950-959
    • Kim, K.1    Zakharkin, S.O.2    Allison, D.B.3
  • 12
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • Epub 2002/02/02
    • van't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002;415(6871):530-6. Epub 2002/02/02.
    • (2002) Nature , vol.415 , Issue.6871 , pp. 530-536
    • Van't Veer, L.J.1    Dai, H.2    Van De Vijver, M.J.3    He, Y.D.4    Hart, A.A.5    Mao, M.6
  • 13
    • 36549060490 scopus 로고    scopus 로고
    • The MINDACT trial: The first prospective clinical validation of a genomic tool
    • Epub 2007/12/01
    • Cardoso F, Piccart-Gebhart M, Van't Veer L, Rutgers E. The MINDACT trial: the first prospective clinical validation of a genomic tool. Mol Oncol. 2007;1(3):246-51. Epub 2007/12/01.
    • (2007) Mol Oncol , vol.1 , Issue.3 , pp. 246-251
    • Cardoso, F.1    Piccart-Gebhart, M.2    Van't Veer, L.3    Rutgers, E.4
  • 14
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Epub 2004/12/14
    • Paik S, Shak S, Tang G, Kim C, Baker J, Cronin M, et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med. 2004;351(27):2817-26. Epub 2004/12/14.
    • (2004) N Engl J Med , vol.351 , Issue.27 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3    Kim, C.4    Baker, J.5    Cronin, M.6
  • 15
    • 45749157664 scopus 로고    scopus 로고
    • Commercialized multigene predictors of clinical outcome for breast cancer
    • Epub 2008/06/03
    • Ross JS, Hatzis C, Symmans WF, Pusztai L, Hortobagyi GN. Commercialized multigene predictors of clinical outcome for breast cancer. Oncologist. 2008;13(5):477-93. Epub 2008/06/03.
    • (2008) Oncologist , vol.13 , Issue.5 , pp. 477-493
    • Ross, J.S.1    Hatzis, C.2    Symmans, W.F.3    Pusztai, L.4    Hortobagyi, G.N.5
  • 16
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Epub 2009/02/21
    • Sotiriou C, Pusztai L. Gene-expression signatures in breast cancer. N Engl J Med. 2009;360(8):790-800. Epub 2009/02/21.
    • (2009) N Engl J Med , vol.360 , Issue.8 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 17
    • 52049095087 scopus 로고    scopus 로고
    • A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer
    • Epub 2008/05/03
    • Ma XJ, Salunga R, Dahiya S, Wang W, Carney E, Durbecq V, et al. A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer. Clin Cancer Res. 2008;14(9):2601-8. Epub 2008/05/03.
    • (2008) Clin Cancer Res , vol.14 , Issue.9 , pp. 2601-2608
    • Ma, X.J.1    Salunga, R.2    Dahiya, S.3    Wang, W.4    Carney, E.5    Durbecq, V.6
  • 18
    • 33144462268 scopus 로고    scopus 로고
    • Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis
    • Epub 2006/02/16
    • Sotiriou C, Wirapati P, Loi S, Harris A, Fox S, Smeds J, et al. Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst. 2006;98(4):262-72. Epub 2006/02/16.
    • (2006) J Natl Cancer Inst , vol.98 , Issue.4 , pp. 262-272
    • Sotiriou, C.1    Wirapati, P.2    Loi, S.3    Harris, A.4    Fox, S.5    Smeds, J.6
  • 20
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Epub 2001/09/13
    • Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A. 2001;98(19):10869-74. Epub 2001/09/13.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.19 , pp. 10869-10874
    • Sorlie, T.1    Perou, C.M.2    Tibshirani, R.3    Aas, T.4    Geisler, S.5    Johnsen, H.6
  • 21
    • 77950308839 scopus 로고    scopus 로고
    • Breast cancer molecular profiling with single sample predictors: A retrospective analysis
    • Epub 2010/02/26
    • Weigelt B, Mackay A, A'Hern R, Natrajan R, Tan DS, Dowsett M, et al. Breast cancer molecular profiling with single sample predictors: a retrospective analysis. Lancet Oncol. 2010;11(4):339-49. Epub 2010/02/26.
    • (2010) Lancet Oncol , vol.11 , Issue.4 , pp. 339-349
    • Weigelt, B.1    Mackay, A.2    A'Hern, R.3    Natrajan, R.4    Tan, D.S.5    Dowsett, M.6
  • 24
    • 77950571895 scopus 로고    scopus 로고
    • Gene expression-based prognostic signatures in lung cancer: Ready for clinical use?
    • Epub 2010/03/18
    • Subramanian J, Simon R. Gene expression-based prognostic signatures in lung cancer: ready for clinical use? J Natl Cancer Inst. 2010;102(7):464-74. Epub 2010/03/18.
    • (2010) J Natl Cancer Inst , vol.102 , Issue.7 , pp. 464-474
    • Subramanian, J.1    Simon, R.2
  • 26
    • 74049135504 scopus 로고    scopus 로고
    • Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris
    • Epub 2008/12/17
    • Boveri T. Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J Cell Sci. 2008;121(Suppl 1):1-84. Epub 2008/12/17.
    • (2008) J Cell Sci , vol.121 , Issue.SUPPL. 1 , pp. 1-84
    • Boveri, T.1
  • 27
    • 0037079003 scopus 로고    scopus 로고
    • Rules for making human tumor cells
    • Epub 2002/11/15
    • Hahn WC, Weinberg RA. Rules for making human tumor cells. N Engl J Med. 2002;347(20):1593-603. Epub 2002/11/15.
    • (2002) N Engl J Med , vol.347 , Issue.20 , pp. 1593-1603
    • Hahn, W.C.1    Weinberg, R.A.2
  • 28
    • 0036561908 scopus 로고    scopus 로고
    • Modelling the molecular circuitry of cancer
    • Epub 2002/06/05
    • Hahn WC, Weinberg RA. Modelling the molecular circuitry of cancer. Nat Rev Cancer. 2002;2(5):331-41. Epub 2002/06/05.
    • (2002) Nat Rev Cancer , vol.2 , Issue.5 , pp. 331-341
    • Hahn, W.C.1    Weinberg, R.A.2
  • 30
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Epub 2004/08/03
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med. 2004;10(8):789-99. Epub 2004/08/03.
    • (2004) Nat Med , vol.10 , Issue.8 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 31
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Epub 2007/10/13
    • Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, Leary RJ, et al. The genomic landscapes of human breast and colorectal cancers. Science. 2007;318(5853):1108-13. Epub 2007/10/13.
    • (2007) Science , vol.318 , Issue.5853 , pp. 1108-1113
    • Wood, L.D.1    Parsons, D.W.2    Jones, S.3    Lin, J.4    Sjoblom, T.5    Leary, R.J.6
  • 32
    • 64749094310 scopus 로고    scopus 로고
    • The cancer genome
    • Epub 2009/04/11
    • Stratton MR, Campbell PJ, Futreal PA. The cancer genome. Nature. 2009;458(7239):719-24. Epub 2009/04/11.
    • (2009) Nature , vol.458 , Issue.7239 , pp. 719-724
    • Stratton, M.R.1    Campbell, P.J.2    Futreal, P.A.3
  • 33
    • 33746255899 scopus 로고    scopus 로고
    • Gene amplification in cancer
    • Epub 2006/06/22
    • Albertson DG. Gene amplification in cancer. Trends Genet. 2006;22(8):447-55. Epub 2006/06/22.
    • (2006) Trends Genet , vol.22 , Issue.8 , pp. 447-455
    • Albertson, D.G.1
  • 34
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Epub 2000/01/27
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57-70. Epub 2000/01/27.
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 35
    • 33947581390 scopus 로고    scopus 로고
    • The impact of translocations and gene fusions on cancer causation
    • Epub 2007/03/16
    • Mitelman F, Johansson B, Mertens F. The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer. 2007;7(4):233-45. Epub 2007/03/16.
    • (2007) Nat Rev Cancer , vol.7 , Issue.4 , pp. 233-245
    • Mitelman, F.1    Johansson, B.2    Mertens, F.3
  • 38
    • 0019183253 scopus 로고
    • On the nature of susceptibility to cancer. The presidential address
    • Epub 1980/09/15
    • Miller DG. On the nature of susceptibility to cancer. The presidential address. Cancer. 1980;46(6):1307-18. Epub 1980/09/15.
    • (1980) Cancer , vol.46 , Issue.6 , pp. 1307-1318
    • Miller, D.G.1
  • 39
    • 38449094794 scopus 로고    scopus 로고
    • Oncogenic transformation and experimental models of human cancer
    • Epub 2007/11/06
    • Schinzel AC, Hahn WC. Oncogenic transformation and experimental models of human cancer. Front Biosci. 2008;13:71-84. Epub 2007/11/06.
    • (2008) Front Biosci , vol.13 , pp. 71-84
    • Schinzel, A.C.1    Hahn, W.C.2
  • 40
    • 0015694748 scopus 로고
    • Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Epub 1973/06/01
    • Rowley JD. Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. 1973;243(5405):290-3. Epub 1973/06/01.
    • (1973) Nature , vol.243 , Issue.5405 , pp. 290-293
    • Rowley, J.D.1
  • 41
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Epub 1996/05/01
    • Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996;2(5):561-6. Epub 1996/05/01.
    • (1996) Nat Med , vol.2 , Issue.5 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3    Ohno, S.4    Segal, G.M.5    Fanning, S.6
  • 42
    • 0024478054 scopus 로고
    • p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor
    • Epub 1989/03/01
    • Hudziak RM, Lewis GD, Winget M, Fendly BM, Shepard HM, Ullrich A. p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor. Mol Cell Biol. 1989;9(3):1165-72. Epub 1989/03/01.
    • (1989) Mol Cell Biol , vol.9 , Issue.3 , pp. 1165-1172
    • Hudziak, R.M.1    Lewis, G.D.2    Winget, M.3    Fendly, B.M.4    Shepard, H.M.5    Ullrich, A.6
  • 43
    • 0026495364 scopus 로고
    • Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors
    • Epub 1992/10/30
    • Kallioniemi A, Kallioniemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F, et al. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science. 1992;258(5083):818-21. Epub 1992/10/30.
    • (1992) Science , vol.258 , Issue.5083 , pp. 818-821
    • Kallioniemi, A.1    Kallioniemi, O.P.2    Sudar, D.3    Rutovitz, D.4    Gray, J.W.5    Waldman, F.6
  • 44
    • 77953006634 scopus 로고    scopus 로고
    • The mutation spectrum revealed by paired genome sequences from a lung cancer patient
    • Epub 2010/05/28
    • Lee W, Jiang Z, Liu J, Haverty PM, Guan Y, Stinson J, et al. The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature. 2010;465(7297):473-7. Epub 2010/05/28.
    • (2010) Nature , vol.465 , Issue.7297 , pp. 473-477
    • Lee, W.1    Jiang, Z.2    Liu, J.3    Haverty, P.M.4    Guan, Y.5    Stinson, J.6
  • 45
  • 46
    • 79952254324 scopus 로고    scopus 로고
    • Available from
    • Administration USFaD. Table of Pharmacogenomic Biomarkers in Drug Labels. 2011; Available from: http://www.fda.gov/drugs/scienceresearch/researchareas/ pharmacogenetics/ucm083378.htm.
    • (2011) Table of Pharmacogenomic Biomarkers in Drug Labels
  • 47
    • 75549090214 scopus 로고    scopus 로고
    • Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer
    • Epub 2009/08/15
    • Neumann J, Zeindl-Eberhart E, Kirchner T, Jung A. Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer. Pathol Res Pract. 2009;205(12):858-62. Epub 2009/08/15.
    • (2009) Pathol Res Pract , vol.205 , Issue.12 , pp. 858-862
    • Neumann, J.1    Zeindl-Eberhart, E.2    Kirchner, T.3    Jung, A.4
  • 48
    • 79551518220 scopus 로고    scopus 로고
    • Kras in metastatic colorectal cancer
    • Epub 2010/11/26
    • Wicki A, Herrmann R, Christofori G. Kras in metastatic colorectal cancer. Swiss Med Wkly. 2010;140:w13112. Epub 2010/11/26.
    • (2010) Swiss Med Wkly , vol.140
    • Wicki, A.1    Herrmann, R.2    Christofori, G.3
  • 50
    • 84862908097 scopus 로고    scopus 로고
    • RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors
    • Epub 2012/01/20
    • Su F, Viros A, Milagre C, Trunzer K, Bollag G, Spleiss O, et al. RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med. 2012;366(3):207-15. Epub 2012/01/20.
    • (2012) N Engl J Med , vol.366 , Issue.3 , pp. 207-215
    • Su, F.1    Viros, A.2    Milagre, C.3    Trunzer, K.4    Bollag, G.5    Spleiss, O.6
  • 51
    • 84856190949 scopus 로고    scopus 로고
    • RAF around the edges - The paradox of BRAF inhibitors
    • Epub 2012/01/20
    • Weeraratna AT. RAF around the edges - the paradox of BRAF inhibitors. N Engl J Med. 2012;366(3):271-3. Epub 2012/01/20.
    • (2012) N Engl J Med , vol.366 , Issue.3 , pp. 271-273
    • Weeraratna, A.T.1
  • 53
    • 74949101897 scopus 로고    scopus 로고
    • Inferring tumor progression from genomic heterogeneity
    • Epub 2009/11/12
    • Navin N, Krasnitz A, Rodgers L, Cook K, Meth J, Kendall J, et al. Inferring tumor progression from genomic heterogeneity. Genome Res. 2010;20(1):68-80. Epub 2009/11/12.
    • (2010) Genome Res , vol.20 , Issue.1 , pp. 68-80
    • Navin, N.1    Krasnitz, A.2    Rodgers, L.3    Cook, K.4    Meth, J.5    Kendall, J.6
  • 54
    • 79961066627 scopus 로고    scopus 로고
    • Advancing a clinically relevant perspective of the clonal nature of cancer
    • Epub 2011/07/07
    • Ruiz C, Lenkiewicz E, Evers L, Holley T, Robeson A, Kiefer J, et al. Advancing a clinically relevant perspective of the clonal nature of cancer. Proc Natl Acad Sci U S A. 2011;108(29):12054-9. Epub 2011/07/07.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.29 , pp. 12054-12059
    • Ruiz, C.1    Lenkiewicz, E.2    Evers, L.3    Holley, T.4    Robeson, A.5    Kiefer, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.