Stat1 interacts with RXRα to upregulate ApoCII gene expression in macrophages

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Trusca, Violeta G ^a   Florea, Irina C ^a   Kardassis, Dimitris ^b   Gafencu, Anca V ^a  

^a INSTITUTE OF CELLULAR BIOLOGY AND PATHOLOGY NICOLAE SIMIONESCU   (Romania)

^b INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN C2; GLUTATHIONE TRANSFERASE; RETINOID X RECEPTOR; SMALL INTERFERING RNA; STAT1 PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; APOLIPOPROTEIN C2 GENE; ARTICLE; BINDING SITE; CELL ISOLATION; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PLASMID; PROMOTER REGION; PROTEIN BINDING; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; APOLIPOPROTEIN C-II; CELL LINE; CHROMOSOMES, HUMAN; ENHANCER ELEMENTS, GENETIC; HEPATOCYTES; HUMANS; MACROPHAGES; MICE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RETINOID X RECEPTOR ALPHA; STAT1 TRANSCRIPTION FACTOR; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84863758315     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040463     Document Type: Article

References (35)

1. Jackson RC, Blobel G, (1977) Post-translational cleavage of presecretory proteins with an extract of rough microsomes from dog pancreas containing signal peptidase activity. Proc Natl Acad Sci U S A 74: 5598-5602.
2. Miller AL, Smith LC, (1973) Activation of lipoprotein lipase by apolipoprotein glutamic acid. Formation of a stable surface film. J Biol Chem 248: 3359-3362.
3. Zannis VI, Kardassis D, Zanni EE, (1993) Genetic mutations affecting human lipoproteins, their receptors, and their enzymes. Adv Hum Genet 21: 145-319.
4. Nilsson-Ehle P, Garfinkel AS, Schotz MC, (1980) Lipolytic enzymes and plasma lipoprotein metabolism. Annu Rev Biochem 49: 667-693.
5. Myklebost O, Williamson B, Markham AF, Myklebost SR, Rogers J, et al. (1984) The isolation and characterization of cDNA clones for human apolipoprotein CII. J Biol Chem 259: 4401-4414.
6. Zannis VI, Cole FS, Jackson CL, Kurnit DM, Karathanasis SK, (1985) Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues. Time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages. Biochemistry 24: 4450-445.
7. Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, et al. (2002) Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. J Biol Chem 277: 31900-31908.
8. Lenich C, Brecher P, Makrides S, Chobanian A, Zannis VI, (1988) Apolipoprotein gene expression in the rabbit: abundance, size, and distribution of apolipoprotein mRNA species in different tissues. J Lipid Res 29: 755-764.
9. Shachter NS, Hayek T, Leff T, Smith JD, Rosenberg DW, et al. (1994) Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice. J Clin Invest 93: 1683-1690.
10. Lusis AJ, Heinzmann C, Sparkes RS, Scott J, Knott TJ, et al. (1986) Regional mapping of human chromosome 19: organization of genes for plasma lipid transport (APOC1,-C2, and-E and LDLR) and the genes C3, PEPD, and GPI. Proc Natl Acad Sci U S A 83: 3929-3933.
11. Wei CF, Tsao YK, Robberson DL, Gotto AM Jr, Brown K, et al. (1985) The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5′ homologous sequences among apolipoprotein genes. J Biol Chem 260: 15211-15221.
12. Allan CM, Walker D, Segrest JP, Taylor JM, (1995) Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus. Genomics 28: 291-300.
13. Vorgia P, Zannis VI, Kardassis D, (1998) A short proximal promoter and the distal hepatic control region-1 (HCR-1) contribute to the liver specificity of the human apolipoprotein C-II gene. Hepatic enhancement by HCR-1 requires two proximal hormone response elements which have different binding specificities for orphan receptors HNF-4, ARP-1, and EAR-2. J Biol Chem 273: 4188-4196.
14. Kardassis D, Sacharidou E, Zannis VI, (1998) Transactivation of the human apolipoprotein CII promoter by orphan and ligand-dependent nuclear receptors. The regulatory element CIIC is a thyroid hormone response element. J Biol Chem 273: 17810-17816.
15. Allan CM, Walker D, Taylor JM, (1995) Evolutionary duplication of a hepatic control region in the human apolipoprotein E gene locus. Identification of a second region that confers high level and liver-specific expression of the human apolipoprotein E gene in transgenic mice. J Biol Chem 270: 26278-26281.
16. Dang Q, Walker D, Taylor S, Allan C, Chin P, et al. (1995) Structure of the hepatic control region of the human apolipoprotein E/C-I gene locus. J Biol Chem 270: 22577-22585.
17. Shih SJ, Allan C, Grehan S, Tse E, Moran C, et al. (2000) Duplicated downstream enhancers control expression of the human apolipoprotein E gene in macrophages and adipose tissue. J Biol Chem 275: 31567-31572.
18. Simonet WS, Bucay N, Pitas RE, Lauer SJ, Taylor JM, (1991) Multiple tissue-specific elements control the apolipoprotein E/C-I gene locus in transgenic mice. J Biol Chem 266: 8651-8654.
19. Lauer SJ, Walker D, Elshourbagy NA, Reardon CA, Levy-Wilson B, et al. (1988) Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene. J Biol Chem 263: 7277-7286.
20. Andersson Y, Majd Z, Lefebvre AM, Martin G, Sechkin AV, et al. (1999) Developmental and pharmacological regulation of apolipoprotein C-II gene expression. Comparison with apo C-I and apo C-III gene regulation. Arterioscler Thromb Vasc Biol 19: 115-121.
21. Kardassis D, Roussou A, Papakosta P, Boulias K, Talianidis I, et al. (2003) Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids. Biochem J 372: 291-304.
22. Grehan S, Tse E, Taylor JM, (2001) Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain. J Neurosci 21: 812-822.
23. Trusca VG, Fuior EV, Florea IC, Kardassis D, Simionescu M, et al. (2011) Macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1 is achieved via long range genomic interactions. J Biol Chem 286: 13891-13904.
24. Goulielmos GN, Petraki E, Vassou D, Eliopoulos E, Iliopoulos D, et al. (2010) The role of the pro-apoptotic protein Siva in the pathogenesis of Familial Mediterranean fever: A structural and functional analysis. Biochem Biophys Res Commun. Nov 5 402(1): 141-146.
25. Tsatsanis C, Androulidaki A, Alissafi T, Charalampopoulos I, Dermitzaki E, et al. (2006) Corticotropin-releasing factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU.1 and AP-1. J Immunol. 176(3): 1869-1877.
26. Mosialou I, Krasagakis K, Kardassis D, (2011) Opposite regulation of the human apolipoprotein M gene by hepatocyte nuclear factor 1 and Jun transcription factors. J Biol Chem. 286(19): 17259-17269.
27. Gafencu AV, Robciuc MR, Fuior E, Zannis VI, Kardassis D, et al. (2007) Inflammatory signaling pathways regulating ApoE gene expression in macrophages. J Biol Chem 282: 21776-21785.
28. Thymiakou E, Zannis VI, Kardassis D, (2007) Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids. Biochemistry 46: 11473-11483.
29. Quandt K, Frech K, Karas H, Wingender E, Werner T, (1995) MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res 23: 4878-4884.
30. Wei CF, Tsao YK, Robberson DL, Gotto AM Jr, Brown K, et al. (1985) The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5′ homologous sequences among apolipoprotein genes. J Biol Chem 260: 15211-15221.
31. Breckenridge WC, Little JA, Steiner G, Chow A, Poapst M, (1978) Hypertriglyceridemia associated with deficiency of apolipoprotein C-II. N Engl J Med 298: 1265-1273.
32. Streicher R, Geisel J, Weisshaar C, Avci H, Oette K, et al. (1996) A single nucleotide substitution in the promoter region of the apolipoprotein C-II gene identified in individuals with chylomicronemia. J Lipid Res 37: 2599-2607.
33. Connelly P W, Maguire GF, Hofmann T, Little JA, (1987) Structure of apolipoprotein C-IIToronto, a nonfunctional human apolipoprotein. Proc Natl Acad Sci U S A 84: 270-273.
34. Jong MC, Havekes LM, (2000) Insights into apolipoprotein C metabolism from transgenic and gene-targeted mice. Int J Tissue React 22: 59-66.
35. Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, et al. (2006) International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev 58: 760-772.