Poly-N-acetyl glucosamine fibers are synergistic with vacuum-assisted closure in augmenting the healing response of diabetic mice

Journal of Trauma - Injury, Infection and Critical Care

Volumn 71, Issue 2 SUPPL. 1, 2011, Pages

  Erba, Paolo ^c   Adini, Avner ^a   Demcheva, Marina ^d   Valeri, C Robert ^e   Orgill, Dennis P ^b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d Marine Polymer Technologies   (United States)

^e Naval Blood Research Laboratory Inc   (United States)

Author keywords

Diabetic mice; Poly N acetyl glucosamine fibers; VAC; Wound healing

Indexed keywords

COLLAGEN TYPE 1; EPIDERMAL GROWTH FACTOR; N ACETYLGLUCOSAMINE; NANOFIBER; PLATELET DERIVED GROWTH FACTOR; POLY N ACETYLGLUCOSAMINE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WOUND HEALING PROMOTING AGENT; POLY N ACETYL GLUCOSAMINE; POLY-N-ACETYL GLUCOSAMINE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; EPITHELIZATION; GRANULATION TISSUE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VACUUM ASSISTED CLOSURE; WOUND CONTRACTION; WOUND HEALING; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; DRUG EFFECT; INJURY; PATHOLOGY; TIME;

ACETYLGLUCOSAMINE; ANIMALS; DIABETES COMPLICATIONS; GRANULATION TISSUE; MALE; MICE; MICE, INBRED C57BL; NANOFIBERS; NEGATIVE-PRESSURE WOUND THERAPY; TIME FACTORS; WOUND HEALING; WOUNDS AND INJURIES;

EID: 84863756915     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e318225583c     Document Type: Article

References (22)

1. Orgill DP, Bayer LR. Advancing the treatment options of chest wounds with negative pressure wound therapy. Ostomy Wound Manage. 2005; 51(2A suppl):39S- 43S. (Pubitemid 40446102)
2. Orgill DP. Utilizing negative pressure wound therapy on open chest/ sternotomy wounds. Ostomy Wound Manage. 2004;50(11A suppl):15S- 17S. (Pubitemid 40090445)
3. Erba P, Rieger UM, Pierer G, Kalbermatten DF. Vacuum-assisted closure (VAC) for venous congestion of the nipple-areola complex. J Plast Reconstr Aesthet Surg. 2008;61:852-854. (Pubitemid 351970490)
4. Marks MW, Argenta LC, Thornton JW. Rapid expansion: experimental and clinical experience. Clin Plast Surg. 1987;14:455-463. (Pubitemid 17108716)
5. Morykwas MJ, Argenta LC, Shelton-Brown EI, McGuirt W. Vacuumassisted closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg. 1997;38:553-562. (Pubitemid 27251299)
6. Moues CM, Vos MC, van den Bemd GJ, Stijnen T, Hovius SE. Bacterial load in relation to vacuum-assisted closure wound therapy: a prospective randomized trial. Wound Repair Regen. 2004;12:11-17. (Pubitemid 38249130)
7. Scherer SS, Pietramaggiori G, Mathews JC, Prsa MJ, Huang S, Orgill DP. The mechanism of action of the vacuum-assisted closure device. Plast Reconstr Surg. 2008;122:786-797.
8. Pietramaggiori G, Liu P, Scherer SS, et al. Tensile forces stimulate vascular remodeling and epidermal cell proliferation in living skin. Ann Surg. 2007;246:896-902. (Pubitemid 350035668)
9. Saxena V, Hwang CW, Huang S, Eichbaum Q, Ingber D, Orgill DP. Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plast Reconstr Surg. 2004;114:1086 -1096; discussion 1097-1098. (Pubitemid 40362027)
10. Pietramaggiori G, Yang HJ, Scherer SS, et al. Effects of poly-N-acetyl glucosamine (pGlcNAc) patch on wound healing in db/db mouse. J Trauma. 2008;64:803-808. (Pubitemid 351366913)
11. King DR, Cohn SM, Proctor KG. Modified rapid deployment hemostat bandage terminates bleeding in coagulopathic patients with severe visceral injuries. J Trauma. 2004;57:756-759. (Pubitemid 39431196)
12. Vournakis JN, Demcheva M, Whitson A, Guirca R, Pariser ER. Isolation, purification, and characterization of poly-N-acetyl glucosamine use as a hemostatic agent. J Trauma. 2004;57(1 suppl):S2-S6. (Pubitemid 39079210)
13. Vournakis JN, Demcheva M, Whitson AB, Finkielsztein S, Connolly RJ. The RDH bandage: hemostasis and survival in a lethal aortotomy hemorrhage model. J Surg Res. 2003;113:1-5. (Pubitemid 36999785)
14. Fischer TH, Bode AP, Demcheva M, Vournakis JN. Hemostatic properties of glucosamine-based materials. J Biomed Mater Res A. 2007;80: 167-174. (Pubitemid 44913344)
15. Ikeda Y, Young LH, Vournakis JN, Lefer AM. Vascular effects of poly-N-acetylglucosamine in isolated rat aortic rings. J Surg Res. 2002; 102:215-220. (Pubitemid 34969470)
16. Scherer SS, Pietramaggiori G, Matthews J, et al. Poly-N-acetyl glucosamine nanofibers: a new bioactive material to enhance diabetic wound healing by cell migration and angiogenesis. Ann Surg. 2009;250:322-330.
17. Aarabi S, Bhatt KA, Shi Y, et al. Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J. 2007;21: 3250-3261. (Pubitemid 47565543)
18. Ogawa R. Keloid and hypertrophic scarring may result from a mechanoreceptor or mechanosensitive nociceptor disorder. Med Hypotheses. 2008;71:493-500.
19. Lambert CA, Soudant EP, Nusgens BV, Lapiere CM. Pretranslational regulation of extracellular matrix macromolecules and collagenase expression in fibroblasts by mechanical forces. Lab Invest. 1992;66:444-451.
20. Watanabe S, Inagaki S, Kinouchi I, Takai H, Masuda Y, Mizuno S. Hydrostatic pressure/perfusion culture system designed and validated for engineering tissue. J Biosci Bioeng. 2005;100:105-111. (Pubitemid 41569354)
21. Kelly DJ, Prendergast PJ. Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects. J Biomech. 2005; 38:1413-1422. (Pubitemid 40744898)
22. McFetridge PS, Abe K, Horrocks M, Chaudhuri JB. Vascular tissue engineering: bioreactor design considerations for extended culture of primary human vascular smooth muscle cells. ASAIO J. 2007;53:623-630. (Pubitemid 47462256)