Endoplasmic reticulum-targeted Bcl-2 inhibitable mitochondrial fragmentation initiates ER stress-induced cell death

Advances in Experimental Medicine and Biology

Volumn 749, Issue , 2012, Pages 83-95

  Bhavya, B C ^a   Indira, Deepa ^a   Seervi, Mahendra ^a   Joseph, Jeena ^a   Sobhan, Praveen K ^a   Mathew, Krupa Ann ^a   Varghese, Saneesh ^a   Santhoshkumar, T R ^a  

^a RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE INHIBITOR; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2;

CANCER CELL; CELL DAMAGE; CELL DEATH; CHROMATIN CONDENSATION; COLON CANCER; CONFERENCE PAPER; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL TARGETING SIGNAL; MITOCHONDRION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SECRETION; PROTEIN TARGETING; PROTEIN TRANSPORT;

CELL DEATH; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; HUMANS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; UNFOLDED PROTEIN RESPONSE;

EID: 84863746948     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-3381-1_7     Document Type: Conference Paper

References (20)

1. Antonsson B, Montessuit S, Lauper S, Eskes R, Martinou JC (2000) Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochem J 345(Pt 2):271-278
2. Berman SB, Pineda FJ, Hardwick JM (2008) Mitochondrial fission and fusion dynamics: the long and short of it. Cell Death Differ 15:1147-1152
3. Chandrika BB, Maney SK, Lekshmi SU, Joseph J, Seervi M et al (2010) Bax deficiency mediated drug resistance can be reversed by endoplasmic reticulum stress induced death signaling. Biochem Pharmacol 79:1589-1599
4. Cheng WC, Teng X, Park HK, Tucker CM, Dunham MJ et al (2008) Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects. Cell Death Differ 15:1838-1846
5. Gu H, Chen X, Gao G, Dong H (2008) Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells. Mol Cancer Ther 7:2298-2307
6. Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, Soto C (2003) Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. EMBO J 22:5435-5445
7. Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M et al (2004) Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol 165:347-356
8. Hockenbery DM, Giedt CD, ONeill JW, Manion MK, Banker DE (2002) Mitochondria and apoptosis: new therapeutic targets. Adv Cancer Res 85:203-242
9. Janssen K, Horn S, Niemann MT, Daniel PT, Schulze-Osthoff K et al (2009) Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis. J Cell Sci 122:4481-4491
10. Karbowski M (2010) Mitochondria on guard: role of mitochondrial fusion and fission in the regulation of apoptosis. Adv Exp Med Biol 687:131-142
11. Karbowski M, Norris KL, Cleland MM, Jeong SY, Youle RJ (2006) Role of Bax and Bak in mitochondrial morphogenesis. Nature 443:658-662
12. Kim I, Xu W, Reed JC (2008) Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 7:1013-1030
13. Lee YJ, Jeong SY, Karbowski M, Smith CL, Youle RJ (2004) Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol Cell 15:5001-5011
14. Mopert K, Hajek P, Frank S, Chen C, Kaufmann J et al (2009) Loss of Drp1 function alters OPA1 processing and changes mitochondrial membrane organization. Exp Cell Res 315:2165-2180
15. Ruiz A, Matute C, Alberdi E (2009) Endoplasmic reticulum Ca(2+) release through ryanodine and IP(3) receptors contributes to neuronal excitotoxicity. Cell Calcium 46:273-281
16. Sheridan C, Delivani P, Cullen SP, Martin SJ (2008) Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release. Mol Cell 31:570-585
17. Westermann B (2010) Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 11:872-884
18. Wu S, Zhou F, Zhang Z, Xing D (2011) Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy. J Cell Physiol 226:530-541
19. Xu C, Bailly-Maitre B, Reed JC (2005) Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115:2656-2664
20. Zhao GJ, Lu ZQ, Yao YM (2010) Advances in mitochondrial fusion- fission and Ca2+ signaling in mammals. Sheng Li Ke Xue Jin Zhan 41:171-176