Is there a therapeutic window for pentoxifylline after the onset of acute pancreatitis?;Existe uma janela terapêutica para a pentoxifilina após o início da pancreatite aguda?

Acta Cirurgica Brasileira

Volumn 27, Issue 7, 2012, Pages 487-493

  Coelho, Ana Maria Mendonça ^a   Kunitake, Tiago Alexandre ^a   Machado, Marcel Cerqueira Cesar ^a   Martins, Joilson Oliveira ^a   Patzina, Rosely Antunes ^a   D'Albuquerque, Luiz Augusto Carneiro ^a   Jukemura, José ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Acute Pancreatitis; Cytokines; Inflammation; Pentoxifylline; Systemic Inflammatory Response

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 6; MYELOPEROXIDASE; PENTOXIFYLLINE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; LUNG; MALE; MORTALITY; NONHUMAN; PANCREAS; PERITONEUM; RAT; SHAM PROCEDURE;

ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERLEUKIN-10; INTERLEUKIN-6; LUNG; MALE; PANCREAS; PANCREATITIS, ACUTE NECROTIZING; PENTOXIFYLLINE; RANDOM ALLOCATION; RATS; RATS, WISTAR; SODIUM CHLORIDE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TIME FACTORS; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863739795     PISSN: 01028650     EISSN: 16782674     Source Type: Journal    
DOI: 10.1590/S0102-86502012000700010     Document Type: Article

References (30)

1. Pitchumoni CS, Patel NM, Shah P: Factors influencing mortality in acute pancreatitis: can we alter them? J Clin Gastroenterol. 2005;39:798-814.
2. Frossard JL, Steer ML, Pastor CM. Acute pancreatitis. Lancet 2008;371:143-52.
3. Bhatia M, Wong FL, Cao Y, Lau HY, Huang J, Puneet P, Chevali L. Pathophysiology of acute pancreatitis. Pancreatology. 2005;5:132-44.
4. Norman J. The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg.1998;175:76-83.
5. Malleo G, Mazzon E, Siriwardena AK, Cuzzocrea S. Role of tumor necrosis factor-alpha in acute pancreatitis: from biological basis to clinical evidence. Shock. 2007;28:130-40.
6. Malleo G, Mazzon E, Genovese T, Di Paola R, Muià C, Centorrino T, Siriwardena AK, Cuzzocrea S. Etanercept attenuates the development of cerulein-induced acute pancreatitis in mice: a comparison with TNF-alpha genetic deletion. Shock. 2007;27:542-51.
7. Yilmaz M, Tekekoglu S, Herek O, Ozmen O, Sahinduran S, Buyukoglu T Ameliorative effect of adalimumab on experimentally induced acute pancreatitis in rats. Pancreas. 2010;39:1238-42.
8. Machado MC, Coelho AM, Martins JO, Sampietre SN, Molan NA, Patzina RA, Machado MA, Jancar S. CO2 abdominal insufflation decreases local and systemic inflammatory response in experimental acute pancreatitis. Pancreas. 2010;39:175-81.
9. Souza LJ, Coelho AM, Sampietre SN, Martins JO, Cunha JE, Machado MC. Anti-inflammatory effects of peritoneal lavage in acute pancreatitis. Pancreas.2010;39:1180-84.
10. Coelho AM, Jukemura J, Sampietre SN, Martins JO, Molan NA, Patzina RA, Lindkvist B, Jancar S, Cunha JE, D'Albuquerque LA, Machado MC. Mechanisms of the beneficial effect of hypertonic saline solution in acute pancreatitis. Shock. 2010;34:502-7.
11. Coimbra R, Melbostad H, Hoyt DB. Effects of phosphodiestarase inhibition on the inflammatory response after shock: role of pentoxifylline. J Trauma. 2004;56:442-49.
12. Deree J, Martins JO, Melbostad H, Loomis WH, Coimbra R. Insights into the regulation of TNF-α production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition. Clinics. 2008;63:321-8.
13. Marton J, Farkas G, Takacs T, Nagy Z, Szasz Z, Varga J, Jarmay K, Balogh A, Lonovics J. Beneficial effects of pentoxifylline treatment of experimental acute pancreatitis in rats. Res Exp Med. 1998;197:293-9.
14. de Campos T, Deree J, Martins JO, Loomis WH, Shenvi E, Putnam JG, Loomis WH, Wolf P,. Coimbra R. Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis. Pancreas. 2008;37:42-9.
15. Sandoval J, Escobar J, Pereda J, Sacilotto N, Rodriguez JL, Sabater L, Aparisi L, Franco L, López-Rodas G, Sastre J. Pentoxifylline prevents loss of PP2A phosphatase activity and recruitment of histone acetyltransferases to proinflammatory genes in acute pancreatitis. J Pharmacol Exp Ther. 2009;331:609-7.
16. Matheus AS, Coelho AM, Sampietre S, Jukemura J, Patzina RA, Cunha JE, Machado MC. Do the effects of pentoxifylline on the inflammatory process and pancreatic infection justify its use in acute pancreatitis? Pancreatology. 2009;9:687-93.
17. Storck G. Fat necrosis in acute pancreatitis. Morphological and chemical studies in the rat. Acta Chir Scand. 1971;417:1-36.
18. Lankisch PG, Ihse I. Bile-induced acute experimental pancreatitis. Scand J Gastroenterol. 1987;22:257-60.
19. Goldblum SE, Wu KM, Jay M. Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits. J Appl Physiol. 1985;59:1978-85.
20. 2-in the neutrophil recruitment into sites of dermal and pulmonary vasculitis. Free Radic Biol Med. 1990;8:163-72.
21. Schmidt J, Rattner DW, Lewandrowski R, Compton CC, Mandavilli U, Knoefel WT, Warshaw AL. A better model of acute pancreatitis for evaluating therapy. Ann Surg. 1992;215:44-56.
22. Simons RK, Maier RV, Chi EY. Pulmonary effects of continuous endotoxin infusion in the rat. Circ Shock. 1991;33:233-43.
23. Hirota M, Nozawa F, Okabe A, Shibata M, Beppu T, Shimada S, Egami H, Yamaguchi Y, Ikei S, Okajima T, Okamoto K, Ogawa. Relationship between plasma cytokine concentration and multiple organ failure in patients with acute pancreatitis. Pancreas. 2000;21:141-6.
24. Coimbra R, Melbostad H, Loomis W, Tobar M, Hoyt DB. Phosphodiesterase inhibition decreases nuclear factor-kappaB activation and shifts the cytokine response toward anti-inflammatory activity in acute endotoxemia. J Trauma. 2005;9:575-82.
25. Vakili A, Mojarrad S, Akhavan MM, Rashidy-Pour A. Pentoxifylline attenuates TNF-α protein levels and brain edema following temporary focal cerebral ischemia in rats. Brain Res. 2011;1377:119-25.
26. Hofken T, Keller N, Fleischer F, Göke B, Wagner AC. Map kinase phosphatases (MKṔs) are early responsive genes during induction of cerulein hyperstimulation pancreatitis. Biochem Biophys Res Commun. 2000;276:680-5.
27. Bassi DG, Foitzik T, Rattner DW, Lewandrowski K, Warshaw AL, Fernández-del Castillo C. Failure of pentoxifylline to ameliorate severe acute pancreatitis in the rat: results of a prospective, randomized, controlled study. Crit Care Med. 1994;22:1960-3.
28. Huh PW, Kotasek D, Jacob HS, Vercellotti GM, Hammerschmidt DE. Mechanism of action of pentoxifylline in peripheral vascular disease: inhibition of platelet and granulocyte responsiveness. Clin Res. 1985;33:866-78.
29. Zhou MT, Chen CS, Chen BC, Zhang QY, Andersson R. Acute lung injury and ARDS in acute pancreatitis: mechanisms and potential intervention. World J Gastroenterol. 2010;16:2094-9.
30. Mayer J, Rau B, Gansauge F, Beger HG. Inflammatory mediators in human acute pancreatitis: clinical and pathophysiological implications. Gut. 2000;47:546-52.