Using eggs from Schistosoma mansoni as an in vivo model of helminth-induced lung inflammation

Journal of Visualized Experiments

Volumn , Issue 64, 2012, Pages 1-

  Joyce, Karen L ^a   Morgan, Will ^b   Greenberg, Robert ^b   Nair, Meera G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alternative activation; Granuloma; Helminth; Immunology; Infection; Inflammation; Issue 64; Lung; Macrophage; Microbiology; Mouse; Parasite; Th2

Indexed keywords

EID: 84863736925     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/3905     Document Type: Article

References (13)

1. World Health Organization, R. Prevention and control of schistosomiasis and soil-transmitted helminthiasis: report of a WHO expert committee. In: WHO Technical Report Series 912, Geneva (2002).
2. Pearce, E.J. & MacDonald, A.S. The immunobiology of schistosomiasis. Nat. Rev. Immunol. 2 (7), 499-511 (2002).
3. Sandler, N.G., et al. Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and th2 responses in tissue repair. J. Immunol. 171 (7), 3655-3667 (2003).
4. Perrigoue, J.G., et al. IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung. J. Exp. Med. 204 (3), 481-487 (2007).
5. Sandor, M., Weinstock, J.V., & Wynn, T.A. Granulomas in schistosome and mycobacterial infections: a model of local immune responses. Trends Immunol. 24 (1), 44-52 (2003).
6. Nair, M.G., et al. Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung. J. Exp. Med. 206 (4), 937-952 (2009).
7. Dalton, J.P., et al. A method for the isolation of schistosome eggs and miracidia free of contaminating host tissues. Parasitology. 115 (Pt. 1), 29-32 (1997).
8. Lewis, F.A., et al. Large-scale laboratory maintenance of Schistosoma mansoni, with observations on three schistosome/snail host combinations. J. Parasitol. 72 (6), 813-829 (1986).
9. Tilney, N.L. Patterns of lymphatic drainage in the adult laboratory rat. J. Anat. 109 (Pt. 3), 369-383 (1971).
10. Lewis, F., Schistosomiasis. Current protocols in immunology, Coligan, John, E., et al., Chapter 19, Unit 19, 1 (2001).
11. Kaplan, M.H., et al. Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. J. Immunol. 160 (4), 1850-1856 (1998).
12. Wynn, T.A. Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat. Rev. Immunol. 4 (8), 583-594 (2004).
13. Cheever, A.W., et al. Variation of hepatic fibrosis and granuloma size among mouse strains infected with Schistosoma mansoni. Am. J. Trop. Med. Hyg. 37 (1), 85-97 (1987).