Role of P2X7 receptors in release of IL-1β: A possible mediator of pulmonary inflammation

Tanaffos

Volumn 11, Issue 2, 2012, Pages 6-11

  Mortaz, Esmaeil ^a,b   Adcock, Ian M ^c   Shafei, Hamed ^a   Masjedi, Mohammad Reza ^b   Folkerts, Gert ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Interleukin 1 ; P2X7 receptor; Pulmonary inflammation

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOKINE; G PROTEIN COUPLED RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2Y RECEPTOR;

AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CAUSE OF DEATH; CHRONIC BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CYTOKINE PRODUCTION; DISEASE COURSE; EMPHYSEMA; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; IMMUNE SYSTEM; INTRACELLULAR SIGNALING; MACROPHAGE; MONOCYTE; PNEUMONIA; RECEPTOR BINDING; REVIEW; TISSUE INJURY;

EID: 84863732490     PISSN: 17350344     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (41)

1. Labasi JM, Petrushova N, Donovan C, McCurdy S, Lira P, Payette MM, et al. Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol 2002; 168 (12): 6436-45.
2. Murrell-Lagnado RD, Qureshi OS. Assembly and trafficking of P2X purinergic receptors (Review). Mol Membr Biol 2008; 25 (4): 321-31.
3. North RA. Families of ion channels with two hydrophobic segments. Curr Opin Cell Biol 1996; 8 (4): 474-83.
4. Mortaz E, Braber S, Nazary M, Givi ME, Nijkamp FP, Folkerts G. ATP in the pathogenesis of lung emphysema. Eur J Pharmacol 2009; 619 (1-3): 92-6.
5. Elssner A, Duncan M, Gavrilin M, Wewers MD. A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release. J Immunol 2004; 172 (8): 4987-94.
6. Cohn ZA, Parks E. The regulation of pinocytosis in mouse macrophages. II. Factors inducing vesicle formation. J Exp Med 1967; 125 (2): 213-32.
7. Di Virgilio F, Borea PA, Illes P. P2 receptors meet the immune system. Trends Pharmacol Sci 2001; 22 (1): 5-7.
8. Ferrari D, Pizzirani C, Adinolfi E, Lemoli RM, Curti A, Idzko M, et al. The P2X7 receptor: a key player in IL-1 processing and release. J Immunol 2006; 176 (7): 3877-83.
9. Kumar V, Sharma A. Adenosine: an endogenous modulator of innate immune system with therapeutic potential. Eur J Pharmacol 2009; 616 (1-3): 7-15.
10. Le Feuvre RA, Brough D, Iwakura Y, Takeda K, Rothwell NJ. Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production. J Biol Chem 2002; 277 (5): 3210-8.
11. Perregaux D, Gabel CA. Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J Biol Chem 1994; 269 (21): 15195-203.
12. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996; 87 (6): 2095-147.
13. Lappalainen U, Whitsett JA, Wert SE, Tichelaar JW, Bry K. Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. Am J Respir Cell Mol Biol 2005; 32 (4): 311-8.
14. Chung KF. Cytokines in chronic obstructive pulmonary disease. Eur Respir J Suppl 2001; 34: 50s-59s.
15. Joos L, McIntyre L, Ruan J, Connett JE, Anthonisen NR, Weir TD, et al. Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers. Thorax 2001; 56 (11): 863-6.
16. Marieb E.N. Human Anatomy & Physiology. San Francisco: Pearson Education, 2004. pp. 388-423.
17. Khakh BS. Molecular physiology of P2X receptors and ATP signalling at synapses. Nat Rev Neurosci 2001; 2 (3): 165-74.
18. Fields RD, Burnstock G. Purinergic signalling in neuron-glia interactions. Nat Rev Neurosci 2006; 7 (6): 423-36.
19. Mortaz E, Folkerts G, Nijkamp FP, Henricks PA. ATP and the pathogenesis of COPD. Eur J Pharmacol 2010; 638 (1-3): 1-4.
20. Polosa R, Blackburn MR. Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease. Trends Pharmacol Sci 2009; 30 (10): 528-35.
21. Stojilkovic S.S. Purinergic Regulation of Hypothalamo-Pituitary Functions. 20 (9), 2009, pp. 460-468.
22. Khakh BS, North RA. P2X receptors as cell-surface ATP sensors in health and disease. Nature 2006; 442 (7102): 527-32.
23. Rang H.P. Pharmacology. sl: Elsevier, 2007. pp. 27-35.
24. Khakh BS. Molecular physiology of P2X receptors and ATP signalling at synapses. Nat Rev Neurosci 2001; 2 (3): 165-74.
25. Pochet S, Garcia-Marcos M, Seil M, Otto A, Marino A, Dehaye JP. Contribution of two ionotropic purinergic receptors to ATP responses in submandibular gland ductal cells. Cell Signal 2007; 19 (10): 2155-64.
26. Lamkanfi M, Kanneganti TD, Franchi L, Núñez G. Caspase-1 inflammasomes in infection and inflammation. J Leukoc Biol 2007; 82 (2): 220-5.
27. Elssner A, Duncan M, Gavrilin M, Wewers MD. A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release. J Immunol 2004; 172 (8): 4987-94.
28. Pelegrin P, Surprenant A. Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J 2006; 25 (21): 5071-82.
29. Hazuda DJ, Strickler J, Kueppers F, Simon PL, Young PR. Processing of precursor interleukin 1 beta and inflammatory disease. J Biol Chem 1990; 265 (11): 6318-22.
30. Dinarello CA. The IL-1 family and inflammatory diseases. Clin Exp Rheumatol 2002; 20 (5 Suppl 27): S1-13.
31. Wewers MD, Sarkar A. P2X(7) receptor and macrophage function. Purinergic Signal 2009; 5 (2): 189-95.
32. Gudipaty L, Munetz J, Verhoef PA, Dubyak GR. Essential role for Ca2+ in regulation of IL-1beta secretion by P2X7 nucleotide receptor in monocytes, macrophages, and HEK-293 cells. Am J Physiol Cell Physiol 2003; 285 (2): C286-99.
33. Andrei C, Margiocco P, Poggi A, Lotti LV, Torrisi MR, Rubartelli A. Phospholipases C and A2 control lysosomemediated IL-1 beta secretion: Implications for inflammatory processes. Proc Natl Acad Sci U S A 2004; 101 (26): 9745-50.
34. MacKenzie A, Wilson HL, Kiss-Toth E, Dower SK, North RA, Surprenant A. Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 2001; 15 (5): 825-35.
35. Morelli A, Chiozzi P, Chiesa A, Ferrari D, Sanz JM, Falzoni S, et al. Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells. Mol Biol Cell 2003; 14 (7): 2655-64.
36. Bianco F, Pravettoni E, Colombo A, Schenk U, Möller T, Matteoli M, et al. Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J Immunol 2005; 174 (11): 7268-77.
37. Pellegatti P, Falzoni S, Pinton P, Rizzuto R, Di Virgilio F. A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion. Mol Biol Cell 2005; 16 (8): 3659-65.
38. Zeidel A, Beilin B, Yardeni I, Mayburd E, Smirnov G, Bessler H. Immune response in asymptomatic smokers. Acta Anaesthesiol Scand 2002; 46 (8): 959-64.
39. Lappalainen U, Whitsett JA, Wert SE, Tichelaar JW, Bry K. Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. Am J Respir Cell Mol Biol 2005; 32 (4): 311-8.
40. Mohsenin A, Blackburn MR. Adenosine signaling in asthma and chronic obstructive pulmonary disease. Curr Opin Pulm Med 2006; 12 (1): 54-9.
41. Eltom S, Stevenson CS, Rastrick J, Dale N, Raemdonck K, Wong S, et al. P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke. PLoS One 2011; 6 (9): e24097.