Proline-glycine-proline as a potential biomarker in chronic obstructive pulmonary disease and cystic fibrosis

Tanaffos

Volumn 11, Issue 2, 2012, Pages 12-15

  ten Hoeve, Arne Lucas ^a   Roda, Mojtaba Abdul ^a   Redegeld, Frank ^a   Folkerts, Gert ^a   Blalock, James Edwin ^b   Gaggar, Amit ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b University of Alabama at Birmingham   (United States)

Author keywords

Chemotactic factors; Chronic obstructive pulmonary disease; Cystic fibrosis; Extracellular matrix; Interleukin 8 and B; Neutrophil activation praline; Serine ednopeptidases

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; CYTOKINE; GELATINASE B; GLYCINE; GLYCOSAMINOGLYCAN; INTERLEUKIN 8; MATRILYSIN; NEUTROPHIL COLLAGENASE; PROLINE;

CHRONIC OBSTRUCTIVE LUNG DISEASE; CYSTIC FIBROSIS; CYTOKINE PRODUCTION; EXTRACELLULAR MATRIX; HUMAN; LEUKOCYTE; LUNG LAVAGE; MACROPHAGE; NEUTROPHIL; PROGNOSIS; REVIEW; SECRETORY VESICLE; SPUTUM ANALYSIS;

EID: 84863732383     PISSN: 17350344     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (20)

1. World Health Organization. Global status report on noncommunicable diseases2010. Chapter 1-Burden: mortality, morbidity and risk factors. 2011.p.9-31.
2. Sin D, van Eeden SF. Neutrophil-mediated lung damage: a new COPD phenotype? Respiration 2012; 83 (2): 103-5.
3. Rowe SM, Miller S, Sorscher EJ. Cystic fibrosis. N Engl J Med 2005; 352 (19): 1992-2001.
4. O'Reilly P, Bailey W. Clinical use of exhaled biomarkers in COPD. Int J Chron Obstruct Pulmon Dis 2007; 2 (4): 403-8.
5. Conese M, Copreni E, Di Gioia S, De Rinaldis P, Fumarulo R. Neutrophil recruitment and airway epithelial cell involvement in chronic cystic fibrosis lung disease. J Cyst Fibros 2003; 2 (3): 129-35.
6. O'Reilly P, Jackson PL, Noerager B, Parker S, Dransfield M, Gaggar A, Blalock JE. N-alpha-PGP and PGP, potential biomarkers and therapeutic targets for COPD. Respir Res 2009; 10: 38.
7. Harada A, Sekido N, Akahoshi T, Wada T, Mukaida N, Matsushima K. Essential involvement of interleukin-8 (IL-8) in acute inflammation. J Leukoc Biol 1994; 56 (5): 559-64.
8. Das ST, Rajagopalan L, Guerrero-Plata A, Sai J, Richmond A, Garofalo RP, Rajarathnam K. Monomeric and dimeric CXCL8 are both essential for in vivo neutrophil recruitment. PLoS One 2010; 5 (7): e11754.
9. Mukaida N. Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. Am J Physiol Lung Cell Mol Physiol 2003; 284 (4): L566-77.
10. Faurschou M, Borregaard N. Neutrophil granules and secretory vesicles in inflammation. Microbes Infect 2003; 5 (14): 1317-27.
11. Smit JJ, Lukacs NW. The missing link: chemokine receptors and tissue matrix breakdown in COPD. Trends Pharmacol Sci 2006; 27 (11): 555-7.
12. Gaggar A, Jackson PL, Noerager BD, O'Reilly PJ, McQuaid DB, Rowe SM, et al. A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation. J Immunol 2008; 180 (8): 5662-9.
13. Morain P, Lestage P, De Nanteuil G, Jochemsen R, Robin JL, Guez D, et al. S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies. CNS Drug Rev 2002; 8 (1): 31-52.
14. Weathington NM, van Houwelingen AH, Noerager BD, Jackson PL, Kraneveld AD, Galin FS, et al. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nat Med 2006; 12 (3): 317-23.
15. Pfister RR, Haddox JL, Sommers CI. Alkali-degraded cornea generates a low molecular weight chemoattractant for polymorphonuclear leukocytes. Invest Ophthalmol Vis Sci 1993; 34 (7): 2297-304.
16. Pfister RR, Haddox JL, Sommers CI, Lam KW. Identification and synthesis of chemotactic tripeptides from alkali-degraded whole cornea. A study of N-acetyl-proline-glycine-proline and N-methyl-proline-glycine-proline. Invest Ophthalmol Vis Sci 1995; 36 (7): 1306-16.
17. Pfister RR, Haddox JL, Sommers CI. Injection of chemoattractants into normal cornea: a model of inflammation after alkali injury. Invest Ophthalmol Vis Sci 1998; 39 (9): 1744-50.
18. Overbeek SA, Henricks PA, Srienc AI, Koelink PJ, de Kruijf P, Lim HD, et al. N-acetylated Proline-Glycine-Proline induced G-protein dependent chemotaxis of neutrophils is independent of CXCL8 release. Eur J Pharmacol 2011; 668 (3): 428-34.
19. O'Reilly PJ, Hardison MT, Jackson PL, Xu X, Snelgrove RJ, Gaggar A, et al. Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen. J Neuroimmunol 2009; 217 (1-2): 51-4.
20. Snelgrove RJ, Jackson PL, Hardison MT, Noerager BD, Kinloch A, Gaggar A, et al. A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation. Science 2010; 330 (6000): 90-4.