HMOX1 promoter (GT)n polymorphism is associated with childhood-onset systemic lupus erythematosus but not with juvenile rheumatoid arthritis in a Mexican population

Clinical and Experimental Rheumatology

Volumn 30, Issue 2, 2012, Pages 297-301

  Córdova, Emilio J ^a   Martínez Hernández, Angélica ^a   Ramírez Bello, Julian ^a,b   Velázquez Cruz, Rafael ^a   Centeno, Federico ^a   Baca, Vicente ^c   Orozco, Lorena ^a,b  

^a INSTITUTO NACIONAL DE MEDICINA GENÓMICA   (Mexico)

^b UNIVERSIDAD AUTÓNOMA DE LA CIUDAD DE MÉXICO   (Mexico)

^c HOSPITAL DE PEDIATRÍA   (Mexico)

Author keywords

Arthritis; HMOX1; Paediatric SLE; Polymorphism

Indexed keywords

HEME OXYGENASE 1;

ARTICLE; CHILD; CONTROLLED STUDY; DINUCLEOTIDE REPEAT; DISEASE PREDISPOSITION; FEMALE; GENE; GENE FREQUENCY; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HEMI OXIGENASE 1 GENE; HETEROZYGOTE; HOMOZYGOSITY; HUMAN; IMMUNOFLUORESCENCE TEST; JUVENILE RHEUMATOID ARTHRITIS; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; MEXICO; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SCHOOL CHILD; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADOLESCENT; AGE OF ONSET; ARTHRITIS, JUVENILE RHEUMATOID; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHILD; DINUCLEOTIDE REPEATS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HEME OXYGENASE-1; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MEXICO; ODDS RATIO; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RISK ASSESSMENT; RISK FACTORS;

EID: 84863732055     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. RYTER SW, CHOI AM: Heme oxygenase-1/ carbon monoxide: from metabolism to molecular therapy. Am J Respir Cell Mol Biol 2009; 41: 251-60.
2. FERRANDIZ ML, DEVESA I: Inducers of heme oxygenase-1. Curr Pharm Des 2008; 14: 473-86.
3. SHINOHARA T, KANEKO T, NAGASHIMA Y, UEDA A, TAGAWA A, ISHIGATSUBO Y: Adenovirus-mediated transfer and overexpression of heme oxygenase 1 cDNA in lungs attenuates elastase-induced pulmonary emphysema in mice. Hum Gene Ther 2005; 16: 318-27.
4. KAPTURCZAK MH, WASSERFALL C, BRUSKO T et al. Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse. Am J Pathol 2004; 165: 1045-53.
5. DEVESA I, FERRANDIZ ML, TERENCIO MC, JOOSTEN LA, VAN DEN BERG WB, ALCARAZ MJ: Influence of heme oxygenase 1 modulation on the progression of murine collageninduced arthritis. Arthritis Rheum 2005; 52: 3230-8.
6. ZWERINA J, TZIMA S, HAYER S et al. Heme oxygenase 1 (HO-1) regulates osteoclastogenesis and bone resorption. FASEB J 2005; 19: 2011-3.
7. TAKEDA Y, TAKENO M, IWASAKI M et al. Chemical induction of HO-1 suppresses lupus nephritis by reducing local iNOS expression and synthesis of anti-dsDNA antibody. Clin Exp Immunol 2004; 138: 237-44.
8. KOBAYASHI H, TAKENO M, SAITO T et al. Regulatory role of heme oxygenase 1 in inflammation of rheumatoid arthritis. Arthritis Rheum 2006; 54: 1132-42.
9. KIRINO Y, TAKENO M, MURAKAMI S et al. Tumor necrosis factor alpha acceleration of inflammatory responses by down-regulating heme oxygenase 1 in human peripheral monocytes. Arthritis Rheum 2007; 56: 464-75.
10. YAMADA N, YAMAYA M, OKINAGA S et al. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet 2000; 66: 187-95.
11. HIRAI H, KUBO H, YAMAYA M et al. Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines. Blood 2003; 102: 1619-21.
12. RUEDA B, OLIVER J, ROBLEDO G et al. HO-1 promoter polymorphism associated with rheumatoid arthritis. Arthritis Rheum 2007; 56: 3953-8.
13. TIROCH K, KOCH W, VON BECKERATH N et al. Heme oxygenase-1 gene promoter polymorphism and restenosis following coronary stenting. Eur Heart J 2007; 28: 968-73.
14. COURTNEY AE, MCNAMEE PT, HEGGARTY S, MIDDLETON D, MAXWELL AP: Association of functional haem oxygenase-1 gene promoter polymorphism with polycystic kidney disease and IgA nephropathy. Nephrol Dial Transplant 2008; 23: 608-11.
15. TAN EM, COHEN AS, FRIES JF et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271-7.
16. SHEU CC, ZHAI R, WANG Z et al. Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome. Intensive Care Med 2009; 35: 1343-51.
17. HAUSMANN M, PAUL G, KELLERMEIER S et al. (GT)N dinucleotide repeat polymorphism of haem oxygenase-1 promotor region is not associated with inflammatory bowel disease risk or disease course. Clin Exp Immunol 2008; 153: 81-5.
18. LO SS, LIN SC, WU CW et al. Heme oxygenase-1 gene promoter polymorphism is associated with risk of gastric adenocarcinoma and lymphovascular tumor invasion. Ann Surg Oncol 2007; 14: 2250-6.
19. CHIN HJ, CHO HJ, LEE TW et al. The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality. J Korean Med Sci 2009; 24 (Suppl.): S30-7.
20. CHOUDHRY S, COYLE NE, TANG H et al. Population stratification confounds genetic association studies among Latinos. Hum Genet 2006; 118: 652-64.
21. TAKAHASHI A, MORI M, NARUTO T et al. The role of heme oxygenase-1 in systemiconset juvenile idiopathic arthritis. Mod Rheumatol 2009; 19: 302-8.
22. MUZ B, KONTNY E, MARCINKIEWICZ J, MASLINSKI W: Heme oxygenase-1 participates in the anti-inflammatory activity of taurine chloramine. Amino Acids 2008; 35: 397-402.
23. BENALLAOUA M, FRANCOIS M, BATTEUX F et al. Pharmacologic induction of heme oxygenase 1 reduces acute inflammatory arthritis in mice. Arthritis Rheum 2007; 56: 2585-94.
24. BAI CH, CHEN JR, CHIU HC, CHOU CC, CHAU LY, PAN WH: Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients. J Biomed Sci 2010; 17: 12.
25. WAGENER FA, TOONEN EJ, WIGMAN L et al. HMOX1 promoter polymorphism modulates the relationship between disease activity and joint damage in rheumatoid arthritis. Arthritis Rheum 2008; 58: 3388-93.
26. TAKEDA M, KIKUCHI M, RATAWAN U et al. Microsatellite polymorphism in the hemo oxygenase-1 gene promoter is associated with susceptibility to Cerebral Malaria in Myanmar. Jpn J Infect Dis 2005; 58: 268-271.
27. ARREDONDO M, JORQUERA D, CARRASCO E et al. Microsatellite polymorphism in the hemo oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus. Am J Ciln Nutr 2007; 86: 1347-53.
28. D'SILVA S, BORSE V, COLAH RB et al. Association of (GT)n repeats promoter polymorphism of hemo oxygenase-1 gene with serum bilirubin levels in healthy indian adults. Genet Test Mol Biomarkers 2011; 15: 215-8.
29. ZANDMAN-GODDARD G, SHOENFELD Y: Hyperferritinemia in autoimmunity. Isr Med Assoc J 2008; 10: 83-4.
30. CÓRDOVA EJ, VELÁZQUEZ-CRUZ R, CENTENO F et al. The NRF2 gene variant, -653G/A, is associated with nephritis in childhood-onset systemic lupus erythematosus. Lupus 2010; 19: 1237-42.