Caspase-1 level is higher in the scalp in androgenetic alopecia

Dermatologic Surgery

Volumn 38, Issue 7 PART 1, 2012, Pages 1033-1039

  De Rivero Vaccari, Juan Pablo ^a   Sawaya, Marty E ^a   Brand III, Frank ^a   Nusbaum, Bernard P ^b   Bauman, Alan J ^c   Bramlett, Helen M ^a   Dietrich, W Dalton ^a   Keane, Robert W ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b Hair Transplant Institute of Miami   (United States)

^c Bauman Medical Group   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; FINASTERIDE; INTERLEUKIN 1BETA CONVERTING ENZYME; TESTOSTERONE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INNATE IMMUNITY; KERATINOCYTE; MALE; MALE TYPE ALOPECIA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

5-ALPHA REDUCTASE INHIBITORS; ADULT; AGED; AGED, 80 AND OVER; ALOPECIA; ANDROGENS; CASPASE 1; CELLS, CULTURED; DIHYDROTESTOSTERONE; FINASTERIDE; HAIR; HUMANS; IMMUNITY, INNATE; IMMUNOHISTOCHEMISTRY; INFLAMMASOMES; KERATINOCYTES; MALE; MIDDLE AGED; SCALP; TESTOSTERONE;

EID: 84863720494     PISSN: 10760512     EISSN: 15244725     Source Type: Journal    
DOI: 10.1111/j.1524-4725.2012.02378.x     Document Type: Article

References (14)

1. Jaworsky C, Kligman AM, Murphy GF,. Characterization of inflammatory infiltrates in male pattern alopecia: implications for pathogenesis. Br J Dermatol 1992; 127: 239-46.
2. Alsantali A, Shapiro J,. Androgens and hair loss. Curr Opin Endocrinol Diabetes Obes 2009; 16: 246-53.
3. Jin Y, Birlea SA, Fain PR, Spritz RA, et al. Genetic variations in NALP1 are associated with generalized vitiligo in a Romanian population. J Invest Dermatol 2007; 127: 2558-62.
4. Jin Y, Mailloux CM, Gowan K, Riccardi SL, et al. NALP1 in vitiligo-associated multiple autoimmune disease. N Engl J Med 2007; 356: 1216-25.
5. Watanabe H, Gaide O, Petrilli V, Martinon F, et al. Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol 2007; 127: 1956-63.
6. Feldmeyer L, Keller M, Niklaus G, Hohl D, et al. The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol 2007; 17: 1140-5.
7. Martinon F, Mayor A, Tschopp J,. The inflammasomes: guardians of the body. Annu Rev Immunol 2009; 27: 229-65.
8. Kuhn JP, Evert M, Friedrich N, Kannengiesser S, et al. Noninvasive quantification of hepatic fat content using three-echo dixon magnetic resonance imaging with correction for T2* relaxation effects. Invest Radiol 2011; 46: 783-9.
9. Sawaya ME, Blume-Peytavi U, Mullins DL, Nusbaum BP, et al. Effects of finasteride on apoptosis and regulation of the human hair cycle. J Cutan Med Surg 2002; 6: 1-9.
10. de Rivero Vaccari JP, Lotocki G, Marcillo AE, Dietrich WD, et al. A molecular platform in neurons regulates inflammation after spinal cord injury. J Neurosci 2008; 28: 3404-14.
11. Whiting DA, HF. Color atlas of differential diagnosis of hair loss. Cedar Grove, NJ: Canfield Publishing; 1996.
12. Rettew JA, Huet-Hudson YM, Marriott I,. Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity. Biol Reprod 2008; 78: 432-7.
13. Kurokawa I, Danby FW, Ju Q, Wang X, et al. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol 2009; 18: 821-32.
14. Bergsbaken T, Fink SL, den Hartigh AB, Loomis WP, et al. Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation. J Immunol 2011; 871: 2748-54.