Infant feeding practices were not associated with breast milk HIV-1 RNA levels in a randomized clinical trial in Botswana

AIDS and Behavior

Volumn 16, Issue 5, 2012, Pages 1260-1264

  Rossenkhan, Raabya ^a,b,c   Novitsky, Vladimir ^a,c   Sebunya, Teresa K ^b   Leidner, Jean ^c   Hagan, Jose E ^a   Moyo, Sikhulile ^a   Smeaton, Laura ^c   Lockman, Shahin ^a,c,d   Musonda, Rosemary ^a,c   Ndung'u, Thumbi ^a   Gaseitsiwe, Simani ^a   Thior, Ibou ^a   Mmalane, Mompati ^a   Makhema, Joseph ^a,c   Essex, M ^a,c,e   Shapiro, Roger ^a,c,f  

^a BOTSWANA HARVARD AIDS INSTITUTE PARTNERSHIP   (Botswana)

^b UNIVERSITY OF BOTSWANA   (Botswana)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e Harvard AIDS Institute   (United States)

^f BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Breast feeding; Exclusive; Mixed; Pmtct; Vertical HIV transmission

Indexed keywords

VIRUS RNA;

ADULT; ARTICLE; ARTIFICIAL MILK; BOTSWANA; BREAST FEEDING; BREAST MILK; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE TRANSMISSION; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; INFANT NUTRITION; MASTITIS; NEWBORN; PREGNANCY; RANDOMIZED CONTROLLED TRIAL; VERTICAL TRANSMISSION; VIROLOGY; VIRUS LOAD;

ADULT; BOTSWANA; BREAST FEEDING; COHORT STUDIES; FEMALE; HIV SEROPOSITIVITY; HUMANS; INFANT; INFANT FORMULA; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MASTITIS; MILK, HUMAN; PREGNANCY; RNA, VIRAL; VIRAL LOAD;

EID: 84863719248     PISSN: 10907165     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10461-011-0035-7     Document Type: Article

References (33)

1. Effect of breastfeeding on infant and child mortality due to infectious diseases in less developed countries: a pooled analysis. WHO Collaborative Study Team on the role of breastfeeding on the prevention of infant mortality. Lancet. 2000;355:451-5.
2. Ahiadeke C. Breast-feeding, diarrhoea and sanitation as components of infant and child health: a study of large scale survey data from Ghana and Nigeria. J Biosoc Sci. 2000;32:47-61. (Pubitemid 30047539)
3. Becquet R, Bequet L, Ekouevi DK, et al. Two-year morbiditymortality and alternatives to prolonged breast-feeding among children born to HIV-infected mothers in Cote d'Ivoire. PLoS Med. 2007;4:e17.
4. Coutsoudis A, Pillay K, Spooner E, Kuhn L, Coovadia HM. Influence of infant-feeding patterns on earlymother-to-child transmission ofHIV-1 in Durban, South Africa: a prospective cohort study. South African vitamin a study group. Lancet. 1999;354:471-6. (Pubitemid 29368926)
5. Creek T, Arvelo W, Kim A, et al. Role of infant feeding and HIV in a severe outbreak of diarrhea and malnutrition among young children, Botswana, 2006. In: CROI 2007: 14th Conference of retroviruses and opportunistic infections, Los Angeles, California, USA, February 25-28, 2007 Abstract 770.
6. Iliff PJ, Piwoz EG, Tavengwa NV, et al. Early exclusive breastfeeding reduces the risk of postnatal HIV-1 transmission and increases HIV-free survival. AIDS. 2005;19:699-708. (Pubitemid 40593075)
7. Kuhn L, Aldrovandi GM, Sinkala M, et al. Effects of early, abrupt weaning on HIV-free survival of children in Zambia. N Engl J Med. 2008;359:130-41. (Pubitemid 351962036)
8. Kuhn L, Sinkala M, Kankasa C, et al. High uptake of exclusive breastfeeding and reduced early post-natal HIV transmission. PLoS One. 2007;2:e1363.
9. Smith MM, Kuhn L. Exclusive breast-feeding: does it have the potential to reduce breast-feeding transmission of HIV-1? Nutr Rev. 2000;58:333-40. (Pubitemid 32009621)
10. Thomas T, Masaba R, van Eijk A, et al. Rates of diarrhea associated with early weaning among infants in Kisumu, Kenya. In: CROI 2007: 14th conference of retroviruses and opportunistic infections, Los Angeles, California, USA, February 25-28, 2007, Abstract 774.
11. Dunn DT, Newell ML, Ades AE, Peckham CS. Risk of human immunodeficiency virus type 1 transmission through breastfeeding. Lancet. 1992;340:585-8.
12. Miotti PG, Taha TE, Kumwenda NI, et al. HIV transmission through breastfeeding: a study in Malawi. JAMA. 1999;282:744-9. (Pubitemid 29404380)
13. Coovadia HM, Rollins NC, Bland RM, et al. Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life: an intervention cohort study. Lancet. 2007;369:1107-16. (Pubitemid 46483637)
14. Lunney KM, Iliff P, Mutasa K, et al. Associations between breast milk viral load, mastitis, exclusive breast-feeding, and postnatal transmission of HIV. Clin Infect Dis. 2010;50:762-9.
15. World Health Organization. HIV and infant feeding. Geneva: World Health Organization, 2010. http://www.who.int/child-adolescent-health/topics/ prevention-care/child/nutrition/hivif/en/index.html.
16. World Health Organization. Rapid advice: revised WHO principles and recommendations on infant feeding in the context of HIV. Geneva: World Health Organization, 2009. http://whqlibdoc.who.int/publications/2009/9789241598873- eng.pdf.
17. Rollins NC, Filteau SM, Coutsoudis A, Tomkins AM. Feeding mode, intestinal permeability, and neopterin excretion: a longitudinal study in infants of HIV-infected South African women. J Acquir Immune Defic Syndr. 2001;28:132-9. (Pubitemid 32971060)
18. Thea DM, Aldrovandi G, Kankasa C, et al. Post-weaning breast milk HIV-1 viral load, blood prolactin levels and breast milk volume. AIDS. 2006;20:1539-47. (Pubitemid 44100215)
19. Semba RD, Kumwenda N, Hoover DR, et al. Human immunodeficiency virus load in breast milk, mastitis, and mother-to-child transmission of human immunodeficiency virus type 1. J Infect Dis. 1999;180:93-8. (Pubitemid 29293922)
20. Willumsen JF, Filteau SM, Coutsoudis A, et al. Breastmilk RNA viral load in HIV-infected South African women: effects of subclinical mastitis and infant feeding. AIDS. 2003;17:407-14. (Pubitemid 36223265)
21. Thior I, Lockman S, Smeaton LM, et al. Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi study. JAMA. 2006;296:794-805. (Pubitemid 44223103)
22. Shapiro RL, Thior I, Gilbert PB, et al. Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in Botswana. AIDS. 2006;20:1281-8. (Pubitemid 44030377)
23. Sinkala M, Kuhn L, Kankasa C, et al. No benefit of early cessation of breastfeeding at 4 months on HIV-free survival of infants born to HIV-infected mothers in Zambia: the Zambia exclusive breastfeeding study. In: CROI 2007: 14th conference on retroviruses and opportunistic infections, Los Angeles, California, USA, February 25-28, 2007, Oral abstract LB 74.
24. Koulinska IN, Villamor E, Chaplin B, et al. Transmission of cellfree and cell-associated HIV-1 through breast-feeding. J Acquir Immune Defic Syndr. 2006;41:93-9. (Pubitemid 41786026)
25. Rousseau CM, Nduati RW, Richardson BA, et al. Association of levels of HIV-1-infected breast milk cells and risk of mother-tochild transmission. J Infect Dis. 2004;190:1880-8. (Pubitemid 39487835)
26. Richardson BA, Nduati R, Mbori-Ngacha D, Overbaugh J, John- Stewart GC. Acute HIV infection among Kenyan infants. Clin Infect Dis. 2008;46:289-95. (Pubitemid 351269172)
27. Shapiro RL, Smeaton L, Lockman S, et al. Risk factors for early and late transmission of HIV via breast-feeding among infants born to HIV-infected women in a randomized clinical trial in Botswana. J Infect Dis. 2009;199:414-8.
28. Chung MH, Kiarie JN, Richardson BA, Lehman DA, Overbaugh J, John-Stewart GC. Breast milk HIV-1 suppression and decreased transmission: a randomized trial comparing HIVNET 012 nevirapine versus short-course zidovudine. AIDS. 2005;19: 1415-22. (Pubitemid 41800678)
29. Chung MH, Kiarie JN, Richardson BA, et al. Highly active antiretroviral therapy versus zidovudine/nevirapine effects on early breast milk HIV type-1 Rna: a phase II randomized clinical trial. Antivir Ther. 2008;13:799-807.
30. Chung MH, Kiarie JN, Richardson BA, et al. Independent effects of nevirapine prophylaxis and HIV-1 RNA suppression in breast milk on early perinatal HIV-1 transmission. J Acquir Immune Defic Syndr. 2007;46:472-8. (Pubitemid 350098699)
31. Manigart O, Crepin M, Leroy V, et al. Effect of perinatal zidovudine prophylaxis on the evolution of cell-free HIV-1 RNA in breast milk and on postnatal transmission. J Infect Dis. 2004;190: 1422-8. (Pubitemid 39332181)
32. Rossenkhan R, Ndung'u T, Sebunya TK, et al. Temporal reduction of HIV type 1 viral load in breast milk by single-dose nevirapine during prevention of MTCT. AIDS Res Hum Retroviruses. 2009;25:1261-4.
33. Tovanabutra S, de Souza M, Sittisombut N, et al. HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01-AE. AIDS. 2007;21:1050-3. (Pubitemid 46684340)