Risk factors for early and late transmission of HIV via breast-feeding among infants born to HIV-infected women in a randomized clinical trial in Botswana

Journal of Infectious Diseases

Volumn 199, Issue 3, 2009, Pages 414-418

  Shapiro, Roger L ^a,b   Smeaton, Laura ^c   Lockman, Shahin ^b,d   Thior, Ibou ^e   Rossenkhan, Raabya ^e   Wester, Carolyn ^e   Stevens, Lisa ^e   Moffat, Claire ^e   Arimi, Peter ^e   Ndase, Patrick ^e   Asmelash, Aida ^e   Leidner, Jean ^c   Novitsky, Vladimir ^b   Makhema, Joseph ^e   Essex, Max ^b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b Department of Immunology and Infectious Diseases ^*  (United States)

^c CENTER FOR BIOSTATISTICS IN AIDS RESEARCH   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e BOTSWANA HARVARD AIDS INSTITUTE PARTNERSHIP   (Botswana)

Author keywords

[No Author keywords available]

Indexed keywords

NEVIRAPINE; PLACEBO; VIRUS RNA; ZIDOVUDINE;

ADULT; ARTICLE; ARTIFICIAL MILK; BIRTH; BLOOD LEVEL; BOTSWANA; BREAST FEEDING; BREAST MILK; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MOTHER; PREDICTION; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SAFETY; VIRUS TRANSMISSION;

ADULT; ANTI-HIV AGENTS; BOTSWANA; BREAST FEEDING; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INFANT; INFANT FORMULA; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MILK, HUMAN; NEVIRAPINE; RISK FACTORS; RNA, VIRAL; ZIDOVUDINE;

EID: 58849123789     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/596034     Document Type: Article

References (14)

1. The Breastfeeding and HIV International Transmission Study Group. Late postnatal transmission of HIV-1 in breast-fed children: an individual patient data meta-analysis. J Infect Dis 2004; 189:2154-66.
2. Thior I, Lockman S, Smeaton LM, et al. Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study. JAMA 2006; 296:794-805.
3. Miotti PG, Taha TE, Kumwenda NI, et al. HIV transmission through breastfeeding: a study in Malawi. JAMA 1999; 282:744-9.
4. Coutsoudis A, Pillay K, Kuhn L, Spooner E, Tsai WY, Coovadia HM. Method of feeding and transmission of HIV-1 from mothers to children by 15 months of age: prospective cohort study from Durban, South Africa. AIDS 2001; 15:379-87.
5. Coovadia HM, Rollins NC, Bland RM, et al. Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life: an intervention cohort study. Lancet 2007; 369:1107-16.
6. Shapiro RL, Thior I, Gilbert PB, et al. Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in Botswana. AIDS 2006; 20:1281-8.
7. Nduati R, John G, Mbori-Ngacha D, et al. Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinical trial. JAMA 2000; 283:1167-74.
8. World Health Organization (WHO). Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants: towards universal access. Recommendations for a public health approach. Geneva, Switzerland: WHO, 2006.
9. Lallemant M, Jourdain G, LeCoeur S, et al. A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus type 1. N Engl J Med 2000; 343:982-91.
10. Kumwenda NI, Hoover DR, Mofenson LM, et al. Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission. N Engl J Med 2008; 359:119-29.
11. Chung MH, Kiarie JN, Richardson BA, Lehman DA, Overbaugh J, John-Stewart GC. Breast milk HIV-1 suppression and decreased transmission: a randomized trial comparing HIVNET 012 nevirapine versus short-course zidovudine. AIDS 2005; 19:1415-22.
12. Rossenkhan R, Ndung'u T, Sebunya TK, et al. Receipt of single dose nevirapine in labor may defer rather than blunt the postpartum breast milk HIV viral load rebound seen after the discontinuation of ZDV [abstract TUPEC029]. In: Program and abstracts of the 4th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention (Sydney, Australia). 2007. Available at: http://www.ias2007.org/PAG/Abstracts.aspx?AID=2915. Accessed 8 December 2008.
13. Taha TE, Hoover DR, Kumwenda NI, et al. Late postnatal transmission of HIV-1 and associated factors. J Infect Dis 2007; 196:10-4.
14. Rousseau CM, Nduati RW, Richardson BA, et al. Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease. J Infect Dis 2003; 187:741-7.