-
1
-
-
34248674146
-
WNT/beta-catenin signaling in liver health and disease
-
Thompson MD, Monga SP, (2007) WNT/beta-catenin signaling in liver health and disease. Hepatology 45: 1298-1305.
-
(2007)
Hepatology
, vol.45
, pp. 1298-1305
-
-
Thompson, M.D.1
Monga, S.P.2
-
2
-
-
54449083925
-
Molecular targeted therapies in hepatocellular carcinoma
-
Llovet JM, Bruix J, (2008) Molecular targeted therapies in hepatocellular carcinoma. Hepatology 48: 1312-1327.
-
(2008)
Hepatology
, vol.48
, pp. 1312-1327
-
-
Llovet, J.M.1
Bruix, J.2
-
3
-
-
33746808398
-
Wnt/beta-catenin signaling in development and disease
-
Clevers H, (2006) Wnt/beta-catenin signaling in development and disease. Cell 127: 469-480.
-
(2006)
Cell
, vol.127
, pp. 469-480
-
-
Clevers, H.1
-
4
-
-
38649093310
-
Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate
-
Decaens T, Godard C, de Reynies A, Rickman DS, Tronche F, et al. (2008) Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate. Hepatology 47: 247-258.
-
(2008)
Hepatology
, vol.47
, pp. 247-258
-
-
Decaens, T.1
Godard, C.2
de Reynies, A.3
Rickman, D.S.4
Tronche, F.5
-
5
-
-
12344308348
-
Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast
-
Kemler R, Hierholzer A, Kanzler B, Kuppig S, Hansen K, et al. (2004) Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development 131: 5817-5824.
-
(2004)
Development
, vol.131
, pp. 5817-5824
-
-
Kemler, R.1
Hierholzer, A.2
Kanzler, B.3
Kuppig, S.4
Hansen, K.5
-
6
-
-
10344254872
-
Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas
-
Colnot S, Decaens T, Niwa-Kawakita M, Godard C, Hamard G, et al. (2004) Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci U S A 101: 17216-17221.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 17216-17221
-
-
Colnot, S.1
Decaens, T.2
Niwa-Kawakita, M.3
Godard, C.4
Hamard, G.5
-
7
-
-
33744495398
-
Apc tumor suppressor gene is the "zonation-keeper" of mouse liver
-
Benhamouche S, Decaens T, Godard C, Chambrey R, Rickman DS, et al. (2006) Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. Dev Cell 10: 759-770.
-
(2006)
Dev Cell
, vol.10
, pp. 759-770
-
-
Benhamouche, S.1
Decaens, T.2
Godard, C.3
Chambrey, R.4
Rickman, D.S.5
-
8
-
-
57749087003
-
B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver
-
Reed KR, Athineos D, Meniel VS, Wilkins JA, Ridgway RA, et al. (2008) B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proc Natl Acad Sci U S A 105: 18919-18923.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 18919-18923
-
-
Reed, K.R.1
Athineos, D.2
Meniel, V.S.3
Wilkins, J.A.4
Ridgway, R.A.5
-
9
-
-
79958827787
-
The transforming growth factor-alpha and cyclin D1 genes are direct targets of beta-catenin signaling in hepatocyte proliferation
-
Torre C, Benhamouche S, Mitchell C, Godard C, Veber P, et al. (2011) The transforming growth factor-alpha and cyclin D1 genes are direct targets of beta-catenin signaling in hepatocyte proliferation. J Hepatol 55: 86-95.
-
(2011)
J Hepatol
, vol.55
, pp. 86-95
-
-
Torre, C.1
Benhamouche, S.2
Mitchell, C.3
Godard, C.4
Veber, P.5
-
10
-
-
34247187543
-
Myc deletion rescues Apc deficiency in the small intestine
-
Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, et al. (2007) Myc deletion rescues Apc deficiency in the small intestine. Nature 446: 676-679.
-
(2007)
Nature
, vol.446
, pp. 676-679
-
-
Sansom, O.J.1
Meniel, V.S.2
Muncan, V.3
Phesse, T.J.4
Wilkins, J.A.5
-
11
-
-
0242691046
-
AP-1: a double-edged sword in tumorigenesis
-
Eferl R, Wagner EF, (2003) AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer 3: 859-868.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 859-868
-
-
Eferl, R.1
Wagner, E.F.2
-
12
-
-
13044281685
-
Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas
-
Mann B, Gelos M, Siedow A, Hanski ML, Gratchev A, et al. (1999) Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci U S A 96: 1603-1608.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 1603-1608
-
-
Mann, B.1
Gelos, M.2
Siedow, A.3
Hanski, M.L.4
Gratchev, A.5
-
13
-
-
24644478136
-
Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
-
Nateri AS, Spencer-Dene B, Behrens A, (2005) Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 437: 281-285.
-
(2005)
Nature
, vol.437
, pp. 281-285
-
-
Nateri, A.S.1
Spencer-Dene, B.2
Behrens, A.3
-
14
-
-
0027242180
-
c-jun is essential for normal mouse development and hepatogenesis
-
Hilberg F, Aguzzi A, Howells N, Wagner EF, (1993) c-jun is essential for normal mouse development and hepatogenesis. Nature 365: 179-181.
-
(1993)
Nature
, vol.365
, pp. 179-181
-
-
Hilberg, F.1
Aguzzi, A.2
Howells, N.3
Wagner, E.F.4
-
15
-
-
0033620648
-
Functions of c-Jun in liver and heart development
-
Eferl R, Sibilia M, Hilberg F, Fuchsbichler A, Kufferath I, et al. (1999) Functions of c-Jun in liver and heart development. J Cell Biol 145: 1049-1061.
-
(1999)
J Cell Biol
, vol.145
, pp. 1049-1061
-
-
Eferl, R.1
Sibilia, M.2
Hilberg, F.3
Fuchsbichler, A.4
Kufferath, I.5
-
16
-
-
0037007208
-
Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver
-
Behrens A, Sibilia M, David JP, Mohle-Steinlein U, Tronche F, et al. (2002) Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. Embo J 21: 1782-1790.
-
(2002)
Embo J
, vol.21
, pp. 1782-1790
-
-
Behrens, A.1
Sibilia, M.2
David, J.P.3
Mohle-Steinlein, U.4
Tronche, F.5
-
17
-
-
33747377165
-
c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
-
Stepniak E, Ricci R, Eferl R, Sumara G, Sumara I, et al. (2006) c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Genes Dev 20: 2306-2314.
-
(2006)
Genes Dev
, vol.20
, pp. 2306-2314
-
-
Stepniak, E.1
Ricci, R.2
Eferl, R.3
Sumara, G.4
Sumara, I.5
-
18
-
-
0037462454
-
Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53
-
Eferl R, Ricci R, Kenner L, Zenz R, David JP, et al. (2003) Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell 112: 181-192.
-
(2003)
Cell
, vol.112
, pp. 181-192
-
-
Eferl, R.1
Ricci, R.2
Kenner, L.3
Zenz, R.4
David, J.P.5
-
19
-
-
77955702663
-
c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair
-
Machida K, Tsukamoto H, Liu JC, Han YP, Govindarajan S, et al. (2010) c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology 52: 480-492.
-
(2010)
Hepatology
, vol.52
, pp. 480-492
-
-
Machida, K.1
Tsukamoto, H.2
Liu, J.C.3
Han, Y.P.4
Govindarajan, S.5
-
20
-
-
36749084608
-
Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase
-
Hasselblatt P, Rath M, Komnenovic V, Zatloukal K, Wagner EF, (2007) Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase. Proc Natl Acad Sci U S A 104: 17105-17110.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 17105-17110
-
-
Hasselblatt, P.1
Rath, M.2
Komnenovic, V.3
Zatloukal, K.4
Wagner, E.F.5
-
21
-
-
84856393784
-
The transcription factor c-Jun protects against sustained hepatic endoplasmic reticulum stress thereby promoting hepatocyte survival
-
Fuest M, Willim K, Macnelly S, Fellner N, Resch GP, et al. (2012) The transcription factor c-Jun protects against sustained hepatic endoplasmic reticulum stress thereby promoting hepatocyte survival. Hepatology 55: 408-418.
-
(2012)
Hepatology
, vol.55
, pp. 408-418
-
-
Fuest, M.1
Willim, K.2
Macnelly, S.3
Fellner, N.4
Resch, G.P.5
-
22
-
-
0035870293
-
Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin
-
Cadoret A, Ovejero C, Saadi-Kheddouci S, Souil E, Fabre M, et al. (2001) Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin. Cancer Res 61: 3245-3249.
-
(2001)
Cancer Res
, vol.61
, pp. 3245-3249
-
-
Cadoret, A.1
Ovejero, C.2
Saadi-Kheddouci, S.3
Souil, E.4
Fabre, M.5
-
23
-
-
66449086571
-
Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism
-
Burke ZD, Reed KR, Phesse TJ, Sansom OJ, Clarke AR, et al. (2009) Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism. Gastroenterology 136: 2316-2324.
-
(2009)
Gastroenterology
, vol.136
, pp. 2316-2324
-
-
Burke, Z.D.1
Reed, K.R.2
Phesse, T.J.3
Sansom, O.J.4
Clarke, A.R.5
-
24
-
-
76749147440
-
Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo
-
Buchert M, Athineos D, Abud HE, Burke ZD, Faux MC, et al. (2010) Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet 6: e1000816.
-
(2010)
PLoS Genet
, vol.6
-
-
Buchert, M.1
Athineos, D.2
Abud, H.E.3
Burke, Z.D.4
Faux, M.C.5
-
25
-
-
46049085203
-
The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus
-
Qian J, Sarnaik AA, Bonney TM, Keirsey J, Combs KA, et al. (2008) The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus. Gastroenterology 135: 152-162.
-
(2008)
Gastroenterology
, vol.135
, pp. 152-162
-
-
Qian, J.1
Sarnaik, A.A.2
Bonney, T.M.3
Keirsey, J.4
Combs, K.A.5
-
26
-
-
54049122614
-
The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice
-
Hasselblatt P, Gresh L, Kudo H, Guinea-Viniegra J, Wagner EF, (2008) The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice. Oncogene 27: 6102-6109.
-
(2008)
Oncogene
, vol.27
, pp. 6102-6109
-
-
Hasselblatt, P.1
Gresh, L.2
Kudo, H.3
Guinea-Viniegra, J.4
Wagner, E.F.5
-
27
-
-
21244472975
-
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
-
Maeda S, Kamata H, Luo JL, Leffert H, Karin M, (2005) IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121: 977-990.
-
(2005)
Cell
, vol.121
, pp. 977-990
-
-
Maeda, S.1
Kamata, H.2
Luo, J.L.3
Leffert, H.4
Karin, M.5
-
28
-
-
78650098891
-
C-jun inhibits mammary apoptosis in vivo
-
Katiyar S, Casimiro MC, Dettin L, Ju X, Wagner EF, et al. (2010) C-jun inhibits mammary apoptosis in vivo. Mol Biol Cell 21: 4264-4274.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 4264-4274
-
-
Katiyar, S.1
Casimiro, M.C.2
Dettin, L.3
Ju, X.4
Wagner, E.F.5
-
29
-
-
0037604501
-
c-Jun regulates eyelid closure and skin tumor development through EGFR signaling
-
Zenz R, Scheuch H, Martin P, Frank C, Eferl R, et al. (2003) c-Jun regulates eyelid closure and skin tumor development through EGFR signaling. Dev Cell 4: 879-889.
-
(2003)
Dev Cell
, vol.4
, pp. 879-889
-
-
Zenz, R.1
Scheuch, H.2
Martin, P.3
Frank, C.4
Eferl, R.5
-
30
-
-
22344435816
-
Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver
-
Tan X, Apte U, Micsenyi A, Kotsagrelos E, Luo JH, et al. (2005) Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver. Gastroenterology 129: 285-302.
-
(2005)
Gastroenterology
, vol.129
, pp. 285-302
-
-
Tan, X.1
Apte, U.2
Micsenyi, A.3
Kotsagrelos, E.4
Luo, J.H.5
-
31
-
-
78650510609
-
mTOR: from growth signal integration to cancer, diabetes and ageing
-
Zoncu R, Efeyan A, Sabatini DM, (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12: 21-35.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
32
-
-
77956627711
-
The role of signaling pathways in the development and treatment of hepatocellular carcinoma
-
Whittaker S, Marais R, Zhu AX, (2010) The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 29: 4989-5005.
-
(2010)
Oncogene
, vol.29
, pp. 4989-5005
-
-
Whittaker, S.1
Marais, R.2
Zhu, A.X.3
-
33
-
-
84857439515
-
AKT and N-Ras co-activation in the mouse liver promotes rapid carcinogenesis via mTORC1, FOXM1/SKP2, and c-Myc pathways
-
Ho C, Wang C, Mattu S, Destefanis G, Ladu S, et al. (2012) AKT and N-Ras co-activation in the mouse liver promotes rapid carcinogenesis via mTORC1, FOXM1/SKP2, and c-Myc pathways. Hepatology 55: 833-845.
-
(2012)
Hepatology
, vol.55
, pp. 833-845
-
-
Ho, C.1
Wang, C.2
Mattu, S.3
Destefanis, G.4
Ladu, S.5
-
34
-
-
77955587900
-
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling
-
Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, et al. (2010) Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell 19: 259-269.
-
(2010)
Dev Cell
, vol.19
, pp. 259-269
-
-
Ashton, G.H.1
Morton, J.P.2
Myant, K.3
Phesse, T.J.4
Ridgway, R.A.5
-
35
-
-
65649130417
-
Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma
-
Augello C, Caruso L, Maggioni M, Donadon M, Montorsi M, et al. (2009) Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma. BMC Cancer 9: 125.
-
(2009)
BMC Cancer
, vol.9
, pp. 125
-
-
Augello, C.1
Caruso, L.2
Maggioni, M.3
Donadon, M.4
Montorsi, M.5
-
36
-
-
0029155706
-
Inducible gene targeting in mice
-
Kuhn R, Schwenk F, Aguet M, Rajewsky K, (1995) Inducible gene targeting in mice. Science 269: 1427-1429.
-
(1995)
Science
, vol.269
, pp. 1427-1429
-
-
Kuhn, R.1
Schwenk, F.2
Aguet, M.3
Rajewsky, K.4
-
37
-
-
0030843461
-
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene
-
Shibata H, Toyama K, Shioya H, Ito M, Hirota M, et al. (1997) Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science 278: 120-123.
-
(1997)
Science
, vol.278
, pp. 120-123
-
-
Shibata, H.1
Toyama, K.2
Shioya, H.3
Ito, M.4
Hirota, M.5
|