Blockade of TGF-β 1 signalling inhibits cardiac NADPH oxidase overactivity in hypertensive rats

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2012, Pages

  Miguel Carrasco, José Luis ^a   Baltanás, Ana ^a   Cebrián, Carolina ^a   Moreno, María U ^a   López, Begñoa ^a   Hermida, Nerea ^a   Gonzlez, Arantxa ^a   Dotor, Javier ^a,b   Borrás Cuesta, Francisco ^a   Deíz, Javier ^a   Fortuño, Ana ^a   Zalba, Guillermo ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN EXPRESSION; COLLAGEN TYPE I; DIFFERENT EFFECTS; IN-CONTROL; NADPH OXIDASE; NITROTYROSINE; POSITIVE CORRELATIONS; SPONTANEOUSLY HYPERTENSIVE RATS; SUPEROXIDE ANIONS; WISTAR-KYOTO RATS;

COLLAGEN; OXYGEN; RATS;

ENZYME INHIBITION;

3 NITROTYROSINE; ALPHA TUBULIN; BIGLYCAN; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; DISITERTIDE; FIBRONECTIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOXYGENASE; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SUPEROXIDE; TRANSFORMING GROWTH FACTOR BETA1; 3-NITROTYROSINE; CYBB PROTEIN, RAT; DRUG DERIVATIVE; MEMBRANE PROTEIN; NOX4 PROTEIN, RAT; PEPTIDE FRAGMENT; TGF BETA1 TYPE III RECEPTOR (730 743), HUMAN; TGF-BETA1 TYPE III RECEPTOR (730-743), HUMAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN METABOLISM; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; HEART MUSCLE FIBROSIS; HYPERTENSION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; ANIMAL; BLOOD PRESSURE; CELL LINE; DRUG ANTAGONISM; ENZYMOLOGY; FIBROBLAST; GENETICS; HEART; HEART MUSCLE; METABOLISM; WISTAR KYOTO RAT;

ANIMALIA; RATTUS;

ANIMALS; BLOOD PRESSURE; CELL LINE; COLLAGEN TYPE I; FIBROBLASTS; HEART; HYPERTENSION; MALE; MEMBRANE GLYCOPROTEINS; MYOCARDIUM; NADPH OXIDASE; PEPTIDE FRAGMENTS; RATS; RATS, INBRED WKY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1; TYROSINE;

EID: 84863702463     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2012/726940     Document Type: Article

References (37)

1. Brown M. J., Haydock S., Pathoaetiology, epidemiology and diagnosis of hypertension Drugs 2000 59 2 1 12 (Pubitemid 30092978)
2. Mensah G. A., Croft J. B., Giles W. H., The heart, kidney, and brain as target organs in hypertension Current Problems in Cardiology 2003 28 156 193
3. Dez J., Gonzlez A., Lpez B., Querejeta R., Mechanisms of disease: pathologic structural remodeling is more than adaptive hypertrophy in hypertensive heart disease Nature Clinical Practice Cardiovascular Medicine 2005 2 4 209 216 (Pubitemid 40812484)
4. Lijnen P. J., Petrov V. V., Fagard R. H., Induction of cardiac fibrosis by transforming growth factor- 1 Molecular Genetics and Metabolism 2000 71 1-2 418 435
5. Border W. A., Noble N. A., Transforming growth factor in tissue fibrosis New England Journal of Medicine 1994 331 19 1286 1292 (Pubitemid 24333194)
6. Mata-Greenwood E., Grobe A., Kumar S., Noskina Y., Black S. M., Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF- 1 and reactive oxygen species: as requirement for NAD(P)H oxidase American Journal of Physiology 2005 289 2 L288 L298
7. Cucoranu I., Clempus R., Dikalova A., Phelan P. J., Ariyan S., Dikalov S., Sorescu D., NAD(P)H oxidase 4 mediates transforming growth factor- 1-induced differentiation of cardiac fibroblasts into myofibroblasts Circulation Research 2005 97 9 900 907 (Pubitemid 41552675)
8. Murillo M. M., Carmona-Cuenca I., Del Castillo G., Ortiz C., Roncero C., Snchez A., Fernndez M., Fabregat I., Activation of NADPH oxidase by transforming growth factor- in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor- B-dependent mechanism Biochemical Journal 2007 405 2 251 259 (Pubitemid 47075160)
9. Thannickal V. J., Fanburg B. L., Activation of an H 2 O 2 -generating NADH oxidase in human lung fibroblasts by transforming growth factor 1 Journal of Biological Chemistry 1995 270 51 30334 30338
10. Ishikawa Y., Nishikimi T., Akimoto K., Ishimura K., Ono H., Matsuoka H., Long-term administration of Rho-kinase inhibitor ameliorates renal damage in malignant hypertensive rats Hypertension 2006 47 6 1075 1083 (Pubitemid 44289164)
11. Liu X. P., Pang Y. J., Zhu W. W., Zhao T. T., Zheng M., Wang Y. B., Sun Z. J., Sun S. J., Benazepril, an angiotensin-converting enzyme inhibitor, alleviates renal injury in spontaneously hypertensive rats by inhibiting advanced glycation end-product-mediated pathways Clinical and Experimental Pharmacology and Physiology 2009 36 3 287 296
12. Namikoshi T., Tomita N., Satoh M., Haruna Y., Kobayashi S., Komai N., Sasaki T., Kashihara N., Olmesartan ameliorates renovascular injury and oxidative stress in zucker obese rats enhanced by dietary protein American Journal of Hypertension 2007 20 10 1085 1091 (Pubitemid 47446169)
13. Ohtomo S., Nangaku M., Izuhara Y., Takizawa S., Strihou C. V. Y. D., Miyata T., Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model Nephrology Dialysis Transplantation 2008 23 4 1166 1172 (Pubitemid 351767476)
14. Briones A. M., Touyz R. M., Oxidative stress and hypertension: current concepts Current Hypertension Reports 2010 12 2 135 142
15. Bedard K., Krause K. H., The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology Physiological Reviews 2007 87 1 245 313 (Pubitemid 46209993)
16. Nabeebaccus A., Zhang M., Shah A. M., NADPH oxidases and cardiac remodelling Heart Failure Reviews 2011 16 1 5 12
17. Martyn K. D., Frederick L. M., Von Loehneysen K., Dinauer M. C., Knaus U. G., Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases Cellular Signalling 2006 18 1 69 82 (Pubitemid 41415716)
18. Dikalov S. I., Dikalova A. E., Bikineyeva A. T., Schmidt H. H. H. W., Harrison D. G., Griendling K. K., Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production Free Radical Biology and Medicine 2008 45 9 1340 1351
19. Santiago B., Gutiérrez-Caas I., Dotor J., Palao G., Lasarte J. J., Ruiz J., Prieto J., Borrs-Cuesta F., Pablos J. L., Topical application of a peptide inhibitor of transforming growth factor- 1 ameliorates bleomycin-induced skin fibrosis Journal of Investigative Dermatology 2005 125 3 450 455
20. Ezquerro I. J., Lasarte J. J., Dotor J., Castilla-Cortzar I., Bustos M., Peuelas I., Blanco G., Rodrguez C., Lechuga M. D. C. G., Greenwel P., Rojkind M., Prieto J., Borrs-Cuesta F., A synthetic peptide from transforming growth factor type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury Cytokine 2003 22 1-2 12 20 (Pubitemid 37222298)
21. Hermida N., Lpez B., Gonzlez A., Dotor J., Lasarte J. J., Sarobe P., Borrs-Cuesta F., Dez J., A synthetic peptide from transforming growth factor- 1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats Cardiovascular Research 2009 81 3 601 609
22. Dabek J., Kuach A., Monastyrska-Cup B., Gasior Z., Transforming growth factor and cardiovascular diseases: the other facet of the protective cytokine Pharmacological Reports 2006 58 6 799 805 (Pubitemid 46117731)
23. US National Institutes of Health, Guide for the Care and Use of Laboratory Animals 1996 Washington, DC, USA NIH Publication no. 85-23
24. Livak K. J., Schmittgen T. D., Analysis of relative gene expression data using real-time quantitative PCR and the 2-CT method Methods 2001 25 4 402 408 (Pubitemid 34164012)
25. Wendt M. C., Daiber A., Kleschyov A. L., Mlsch A., Sydow K., Schulz E., Chen K., Keaney J. F., Lassgue B., Walter U., Griendling K. K., Mnzel T., Differential effects of diabetes on the expression of the gp91 phox homologues nox1 and nox4 Free Radical Biology and Medicine 2005 39 3 381 391 (Pubitemid 40910195)
26. Wu R., Laplante M. A., De Champlain J., Prevention of angiotensin II-induced hypertension, cardiovascular hypertrophy and oxidative stress by acetylsalicylic acid in rats Journal of Hypertension 2004 22 4 793 801 (Pubitemid 38543572)
27. Massagué J., Like B., Cellular receptors for type transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines Journal of Biological Chemistry 1985 260 5 2636 2645 (Pubitemid 15139314)
28. Lpez-Casillas F., Wrana J. L., Massagué J., Betaglycan presents ligand to the TGF signaling receptor Cell 1993 73 7 1435 1444 (Pubitemid 23201155)
29. Arozal W., Watanabe K., Veeraveedu P. T., Ma M., Thandavarayan R. A., Suzuki K., Tachikawa H., Kodama M., Aizawa Y., Effects of angiotensin receptor blocker on oxidative stress and cardio-renal function in streptozotocin-induced diabetic rats Biological and Pharmaceutical Bulletin 2009 32 8 1411 1416
30. Nagata K., Somura F., Obata K., Odashima M., Izawa H., Ichihara S., Nagasaka T., Iwase M., Yamada Y., Nakashima N., Yokota M., AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats Hypertension 2002 40 2 168 174 (Pubitemid 34840093)
31. Esparza-Lpez J., Montiel J. L., Vilchis-Landeros M. M., Okadome T., Miyazono K., Lpez-Casillas F., Ligand binding and functional properties of betaglycan, a co-receptor of the transforming growth factor- superfamily. Specialized binding regions for transforming growth factor- and inhibin A Journal of Biological Chemistry 2001 276 18 14588 14596
32. Buday A., Orsy P., God M., Mzes M., Kkény G., Lacza Z., Koller., Ungvri Z., Gross M. L., Beny Z., Hamar P., Elevated systemic TGF- impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE -/- mice American Journal of Physiology 2010 299 2 H386 H395
33. Ohno T., Kobayashi N., Yoshida K., Fukushima H., Matsuoka H., Cardioprotective effect of benidipine on cardiac performance and remodeling in failing rat hearts American Journal of Hypertension 2008 21 2 224 230 (Pubitemid 351231579)
34. Li S., Li X., Zheng H., Xie B., Bidasee K. R., Rozanski G. J., Pro-oxidant effect of transforming growth factor- 1 mediates contractile dysfunction in rat ventricular myocytes Cardiovascular Research 2008 77 1 107 117 (Pubitemid 351195150)
35. Woo C. H., Lee Z. W., Kim B. C., Ha K. S., Kim J. H., Involvement of cytosolic phospholipase A2, and the subsequent release of arachidonic acid, in signalling by Rac for the generation of intracellular reactive oxygen species in Rat-2 fibroblasts Biochemical Journal 2000 348 3 525 530
36. Papparella I., Ceolotto G., Berto L., Cavalli M., Bova S., Cargnelli G., Ruga E., Milanesi O., Franco L., Mazzoni M., Petrelli L., Nussdorfer G. G., Semplicini A., Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat Cardiovascular Research 2007 73 2 432 438 (Pubitemid 44937699)
37. Nakamura T., Yamamoto E., Kataoka K., Yamashita T., Tokutomi Y., Dong Y. F., Matsuba S., Ogawa H., Kim-Mitsuyama S., Beneficial effects of pioglitazone on hypertensive cardiovascular injury are enhanced by combination with candesartan Hypertension 2008 51 2 296 301 (Pubitemid 351159942)