The placebo in practice: How to use it in clinical routine

Current Opinion in Supportive and Palliative Care

Volumn 6, Issue 2, 2012, Pages 220-225

  Carlino, Elisa ^a   Pollo, Antonella ^a   Benedetti, Fabrizio ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Expectations; Healing process; Learning; Placebo

Indexed keywords

ATTITUDE TO HEALTH; EMPATHY; HUMAN; INTERPERSONAL COMMUNICATION; LEARNING; PLACEBO EFFECT; REVIEW; TREATMENT OUTCOME;

COMMUNICATION; EMPATHY; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HUMANS; LEARNING; PLACEBO EFFECT; TREATMENT OUTCOME;

EID: 84863683728     PISSN: 17514258     EISSN: 17514266     Source Type: Journal    
DOI: 10.1097/SPC.0b013e32835269c1     Document Type: Review

References (56)

1. Benedetti F, Carlino E, Pollo A. How placebos change the patient's brain. Neuropsychopharmacology 2011; 36:339-354.
2. Dominick C, Lorenz J, Hauck M. Somatotopy of placebo analgesia is independent of spatial attention. J Pain Res 2011; 4:79-83.
3. Colloca L, Petrovic P, Wager TD, et al. How the number of learning trials affects placebo and nocebo responses. Pain 2010; 151:430-439.
4. Morton DL, Brown CA, Watson A, et al. Cognitive changes as a result of single exposure to placebo. Neuropsychologia 2010; 48:1958-1964.
5. Van Laarthover AIM, Vogelaar M, Wildser-Smith OH, et al. Induction of nocebo and placebo effects on itch and pain by verbal suggestions. Pain 2011; 152:1486-1494.
6. De la Fuente-Fernandez R, Phillips AG, Zamburlini M, et al. Dopamine release in human ventral striatum and expectation of reward. Behav Brain Res 2002; 136:359-363. (Pubitemid 35333251)
7. De la Fuente-Fernandez R. The placebo-reward hypothesis: dopamine and the placebo effect. Parkinsonism Relat Disord 2009; 15S3:S72-S74.
8. Benedetti F, Lanotte M, Colloca L, et al. Electrophysiological properties of thalamic, subthalamic and nigral neurons during the antiparkinsonian placebo response. J Physiol 2009; 587:3869-3883.
9. Lidstone SC, Schulzer M, Dinelle K, et al. Effects of expectation on placebo-induced dopamine release in Parkinson disease. Arch Gen Psychiatry 2010; 67:857-865.
10. Leuchter AF, Cook IA, Witte EA, et al. Changes in brain function of depressed subjects during treatment with placebo. Am J Psychiatry 2002; 159:122-129. (Pubitemid 41070737)
11. Leuchert AF, McCracken JT, Hunter AM, et al. Monoamine oxidase A and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder. J Clin Psychopharmacol 2009; 29:372-437.
12. Colloca L, Benedetti F. Nocebo hyperalgesia: how anxiety is turned into pain. Curr Opin Anaesthesiol 2007; 20:435-439. (Pubitemid 47415134)
13. Furmark T, Appel L, Henningsson S, et al. A link between serotonin-related gene polymorphisms, amygdale activity, and placebo-induced relief from social anxiety. J Neurosci 2008; 28:13066-13074.
14. Pacheco-Lopez G, Engler H, Niemi MB, Schedlowski M. Expectations and associations that heal: immunomodulatory placebo effects and its neurobiol-ogy. Brain Behav Immun 2006; 20:430-446. (Pubitemid 44175800)
15. Schedlowski M, Pacheco-Lopez G. The learned immune response: Pavlov and beyond. Brain Behav Immun 2010; 24:176-185.
16. Grigoleit JS, Kullmann JS, Winkelhaus A, et al. Single-trial conditioning in a human taste endotoxin paradigm induces conditioned odor aversion but not cytokine responses. Brain Behav Immun 2012; 26:234-238.
17. Wirth T, Ober K, Prager G, et al. Repeated recall of learned immunosuppression: evidence from rats and men. Brain Behav Immun 2011; 25:1444-1451.
18. Beedie CJ, Stuart EM, Coleman DA, Foad AJ. Placebo effects of caffeine on cycling performance. Med Sci Sports Exerc 2006; 38:2159-2164. (Pubitemid 44888682)
19. Beedie CJ, Coleman DA, Foad AJ. Positive and negative placebo effects resulting from the deceptive administration of an ergogenic aid. Int J Sport Nutr Exerc Metab 2007; 17:259-269. (Pubitemid 47124219)
20. Pollo A, Carlino E, Benedetti F. The top-down influenceofergogenic placebos on muscle work and fatigue. Eur J Neurosci 2008; 28:379-388.
21. Wechsler ME, Kelley JM, Boyd IO, et al. Active albuterol or placebo, sham acupuncture, or no intervention in asthma. N Engl J Med 2011; 365:119-126.
22. Amanzio M, Benedetti F. Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems. J Neurosci 1999; 19:484-494. (Pubitemid 29028987)
23. Benedetti F, Arduino C, Amanzio M. Somatotopic activation of opioid systems by target-directed expectations of analgesia. J Neurosci 1999; 19:3639-3648. (Pubitemid 29203142)
24. Petrovic P, Kalso E, Petersson KM, Ingvar M. Placebo and opioid analgesia - imagine: a shared neuronal network. Science 2002; 295:1737-1740. (Pubitemid 34202913)
25. Zubieta JK, Bueller JA, Jackson LR, et al. Placebo effects mediated by endogenous opioid activity on opioid receptors. J Neurosci 2005; 25:7754-7762. (Pubitemid 41208646)
26. Guo JY, Wang JY, Luo F. Dissection of placebo analgesia in mice: the conditions for activation of opioid and nonopioid systems. J Psychopharmacol 2009; 24:1561-1567.
27. Stern J, Candia V, Porchet RI, et al. Placebo-mediated, naloxone-sensitive suggestibility of short-term memory performance. Neurobiol Learn Mem 2011; 95:326-334.
28. Benedetti F, Amanzio M, Maggi G. Potentiation of placebo analgesia by proglumide. Lancet 1995; 346:1231.
29. Benedetti F, Amanzio M, Thoen W. Disruption of opioid-induced placebo responses by activation of cholecystokinin type-2 receptors. Psychopharmacology 2011; 213:791-797.
30. Benedetti F, Amanzio M, Rosato R, Blanchard C. Nonopioid placebo analgesia in mediated by CB1 cannabinoid receptors. Nat Med 2011; 17:1228-1230.
31. Wager TD, Rilling JK, Smith EE, et al. Placebo-induced changes in fMRI in the anticipation and experience of pain. Science 2004; 303:1162-1167. (Pubitemid 38233575)
32. Benedetti F, Arduino C, Costa S, et al. Loss of expectation-related mechanisms in Alzheimer's disease makes analgesic therapies less effective. Pain 2006; 121:133-144. (Pubitemid 43261640)
33. Bingel U, Lorenz J, Schoell E, et al. Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network. Pain 2006; 120:8-15. (Pubitemid 43078587)
34. Eippert F, Bingel U, Schoell ED, et al. Activation of the opioidergic descending pain control system underlies placebo analgesia. Neuron 2009; 63:533-543.
35. Lui F, Colloca L, Duzzi D, et al. Neural bases of conditioned placebo analgesia. Pain 2010; 151:816-824.
36. Krummenacher P, Candia V, Folkers G, et al. Prefrontal cortex modulates placebo analgesia. Pain 2010; 148:368-374.
37. Amanzio M, Benedetti F, Porro CA, et al. Activation likelihood estimation metaanalysis of brain correlates of placebo analgesia in human experimental pain. Hum Brain Map 2012; doi: 10.1002/hbm.21471 [Epub ahead of print].
38. Price DD, Finniss DG, Benedetti F. A comprehensive review of the placebo effect: recent advances and current thought. Annu Rev Psychol 2008; 59:565-590.
39. Pollo A, Benedetti F. The placebo response: neurobiological and clinical issues of neurological relevance. Prog Brain Res 2009; 175:283-294.
40. Finnis DG, Kaptchuk TJ, Miller F, Benedetti F. Biological, clinical, and ethical advances of placebo effects. Lancet 2010; 375:686-695.
41. Tracey I. Getting the pain you expected: mechanisms of placebo, nocebo and reappraisal effects in humans. Nat Med 2010; 16:1277-1283.
42. Bensing JM, Verheul W. The silent healer: the role of communication in placebo effects. Patient Educ Couns 2010; 80:293-299.
43. Geers AL, Helfer SG, Kosbab K, et al. Reconsidering the role of personality in placebo effects: dispositional optimism, situational expectations, and placebo response. J Psychosom Res 2005; 58:121-127.
44. Kaptchuk TJ, Friedlander E, Kelley JM, et al. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS One 2010; 5:e15591.
45. Engle GL. How much longer must medicine's science be bound by a seventeenth century world view. Psychother Psychosom 1992; 57:3-16.
46. Kelley JM, Lembo AJ, Ablon S, et al. Patient and practitioner influences on the placebo effect in irritable bowel syndrome. Psychosom Med 2009; 71:789-797.
47. Verheul W, Sanders A, Bensing JM. The effects of physicians' affect-oriented communication style and raising expectations on analogue patients' anxiety, affect and expectancies. Patient Educ Couns 2010; 80:300-306.
48. Rose JP, Geers AL, Rasinski M, Fowler SL. Choice and placebo expectation effects in the context of pain analgesia. J Behav Med 2012; doi: 10.1007/s10865-011-9374-0 [Epub ahead of print].
49. Stewart M, Brown JB, Weston WW, et al. Patient-centered medicine: transforming the clinical method. 2nd ed. Abingdon, UK: Radcliffe Medical Press; 2003.
50. Vits S, Cesko E, Enck P, et al. Behavioural conditioning as the mediator of placebo responses in the immune system. Philos Trans R Soc Lond B Biol Sci 2011; 366:1799-1807.
51. Ader R, Mercurio MG, Walton J, et al. Conditioned pharmacotherapeutic effects: a preliminary study. Psychosom Med 2010; 72:192-197.
52. Rief W, Bingel U, Schedlowski M, Enck P. Mechanisms involved in placebo and nocebo responses and implications for drug trials. Clin Pharmacol Ther 2011; 90:722-726.
53. Benedetti F, Carlino E, Pollo A. Hidden administration of drugs. Clin Pharmacol Ther 2011; 90:651-661.
54. Bingel U, Wanigasekera V, Wiech K, et al. The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil. Sci Transl Med 2011; 3:70ra14.
55. Bjorkedal E, Flaten MA. Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo. Psychopharmacology 2011; 215:537-548.
56. Amanzio M, Corazzini LL, Vase L, Benedetti F. A systematic review of adverse events in placebo groups of antimigraine clinical trials. Pain 2009; 146:261-269.