Five questions on prion diseases

PLoS Pathogens

Volumn 8, Issue 5, 2012, Pages

  Aguzzi, Adriano ^a   Zhu, Caihong ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

LACTADHERIN; PRION PROTEIN;

AEROSOL; ARTICLE; AUTONOMIC NERVE; B LYMPHOCYTE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CHRONIC WASTING DISEASE; DISEASE TRANSMISSION; FOLLICULAR DENDRITIC CELL; GENE MUTATION; HUMAN; IMMUNE SYSTEM; INFUSION; INHALATION; INTRACEREBRAL DRUG ADMINISTRATION; MAMMAL; NONHUMAN; PARENTERAL DRUG ADMINISTRATION; PHAGOCYTOSIS; PRION DISEASE; PROTEIN ANALYSIS; PROTEIN DEGRADATION; SCRAPIE; ANIMAL; CHEMISTRY; METABOLISM; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; PRION;

ANIMALS; B-LYMPHOCYTES; CENTRAL NERVOUS SYSTEM; DENDRITIC CELLS, FOLLICULAR; HUMANS; PRION DISEASES; PRIONS;

EID: 84863682685     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002651     Document Type: Article

References (29)

1. Aguzzi A, Weissmann C, (1997) Prion research: the next frontiers. Nature 389: 795-798.
2. Bruce ME, Will RG, Ironside JW, McConnell I, Drummond D, et al. (1997) Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. Nature 389: 498-501.
3. Peden A, McCardle L, Head MW, Love S, Ward HJ, et al. (2010) Variant CJD infection in the spleen of a neurologically asymptomatic UK adult patient with haemophilia. Haemophilia 16: 296-304.
4. Bernoulli C, Siegfried J, Baumgartner G, Regli F, Rabinowicz T, et al. (1977) Danger of accidental person-to-person transmission of Creutzfeldt-Jakob disease by surgery. Lancet 1: 478-479.
5. Denkers ND, Seelig DM, Telling GC, Hoover EA, (2010) Aerosol and nasal transmission of chronic wasting disease in cervidized mice. J Gen Virol 91: 1651-1658.
6. Haybaeck J, Heikenwalder M, Klevenz B, Schwarz P, Margalith I, et al. (2011) Aerosols transmit prions to immunocompetent and immunodeficient mice. PLoS Pathog 7: e1001257 doi:10.1371/journal.ppat.1001257.
7. Klein MA, Frigg R, Flechsig E, Raeber AJ, Kalinke U, et al. (1997) A crucial role for B cells in neuroinvasive scrapie. Nature 390: 687-690.
8. Brown KL, Stewart K, Ritchie DL, Mabbott NA, Williams A, et al. (1999) Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells. Nat Med 5: 1308-1312.
9. Prinz M, Montrasio F, Klein MA, Schwarz P, Priller J, et al. (2002) Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells. Proc Natl Acad Sci U S A 99: 919-924.
10. Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, et al. (2008) Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity 29: 998-1008.
11. McBride PA, Schulz-Schaeffer WJ, Donaldson M, Bruce M, Diringer H, et al. (2001) Early spread of scrapie from the gastrointestinal tract to the central nervous system involves autonomic fibers of the splanchnic and vagus nerves. J Virol 75: 9320-9327.
12. Glatzel M, Heppner FL, Albers KM, Aguzzi A, (2001) Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion. Neuron 31: 25-34.
13. Brandner S, Isenmann S, Raeber A, Fischer M, Sailer A, et al. (1996) Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature 379: 339-343.
14. Lauren J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM, (2009) Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 457: 1128-1132.
15. Gimbel DA, Nygaard HB, Coffey EE, Gunther EC, Lauren J, et al. (2010) Memory impairment in transgenic Alzheimer mice requires cellular prion protein. J Neurosci 30: 6367-6374.
16. Balducci C, Beeg M, Stravalaci M, Bastone A, Sclip A, et al. (2010) Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein. Proc Natl Acad Sci U S A 107: 2295-2300.
17. Kessels HW, Nguyen LN, Nabavi S, Malinow R, (2010) The prion protein as a receptor for amyloid-beta. Nature 466: E3-4; discussion E4-5.
18. Calella AM, Farinelli M, Nuvolone M, Mirante O, Moos R, et al. (2010) Prion protein and Abeta-related synaptic toxicity impairment. EMBO Mol Med 2: 306-314.
19. Shmerling D, Hegyi I, Fischer M, Blattler T, Brandner S, et al. (1998) Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell 93: 203-214.
20. Baumann F, Tolnay M, Brabeck C, Pahnke J, Kloz U, et al. (2007) Lethal recessive myelin toxicity of prion protein lacking its central domain. EMBO J 26: 538-547.
21. Li A, Christensen HM, Stewart LR, Roth KA, Chiesa R, et al. (2007) Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125. EMBO J 26: 548-558.
22. Westergard L, Turnbaugh JA, Harris DA, (2011) A nine amino Acid domain is essential for mutant prion protein toxicity. J Neurosci 31: 14005-14017.
23. Behrens A, Aguzzi A, (2002) Small is not beautiful: antagonizing functions for the prion protein PrP(C) and its homologue Dpl. Trends Neurosci 25: 150-154.
24. Chiesa R, Piccardo P, Ghetti B, Harris DA, (1998) Neurological illness in transgenic mice expressing a prion protein with an insertional mutation. Neuron 21: 1339-1351.
25. Glatzel M, Mohajeri MH, Poirier R, Nitsch RM, Schwarz P, et al. (2005) No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesis. J Gen Virol 86: 1861-1867.
26. Falsig J, Julius C, Margalith I, Schwarz P, Heppner FL, et al. (2008) A versatile prion replication assay in organotypic brain slices. Nat Neurosci 11: 109-117.
27. Kranich J, Krautler NJ, Falsig J, Ballmer B, Li S, et al. (2010) Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner. J Exp Med 207: 2271-2281.
28. Yu G, Chen J, Yu H, Liu S, Xu X, et al. (2006) Functional disruption of the prion protein gene in cloned goats. J Gen Virol 87: 1019-1027.
29. Zhu C, Li B, Yu G, Chen J, Yu H, et al. (2009) Production of Prnp -/- goats by gene targeting in adult fibroblasts. Transgenic Res 18: 163-171.