Antibody response to Streptococcus pneumoniae proteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in children

Human Vaccines and Immunotherapeutics

Volumn 8, Issue 6, 2012, Pages 799-805

  Pichichero, Michael E ^a   Kaur, Ravinder ^a   Casey, Janet R ^b   Xu, Qingfu ^a   Almudevar, Anthony ^c   Ochs, Martina ^d  

^a ROCHESTER GENERAL HOSPITAL   (United States)

^b Legacy Pediatrics   (United States)

^c UNIVERSITY OF ROCHESTER   (United States)

^d Sanofi Pasteur   (Canada)

Author keywords

Acute otitis media; LytB; PcpA; PhtD; PhtE; Ply; Streptococcus pneumoniae

Indexed keywords

BACTERIAL PROTEIN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; PNEUMOCOCCAL HISTIDINE TRIAD D; PNEUMOLYSIN; PROTEIN LYTB; PROTEIN PCPA; PROTEIN PHTE; UNCLASSIFIED DRUG;

ACUTE OTITIS MEDIA; AGE DISTRIBUTION; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM ADHERENCE; CHILD; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; INFANT; NASOPHARYNX; NONHUMAN; NORMAL HUMAN; PRESCHOOL CHILD; PROSPECTIVE STUDY; SEROTYPE; STREPTOCOCCUS PNEUMONIAE;

ANTIBODIES, BACTERIAL; ANTIBODY FORMATION; BACTERIAL PROTEINS; CARRIER PROTEINS; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; MALE; N-ACETYLMURAMOYL-L-ALANINE AMIDASE; NASOPHARYNX; OTITIS MEDIA; STREPTOCOCCUS PNEUMONIAE; STREPTOLYSINS;

EID: 84863681117     PISSN: None     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/hv.19820     Document Type: Article

References (22)

1. Casey JR, Pichichero ME. Changes in frequency and pathogens causing acute otitis media in 1995-2003. Pediatr Infect Dis J 2004; 23:824-8; PMID:15361720; http://dx.doi.org/10.1097/01.inf.0000136871.51792.19.
2. Block SL, Hedrick J, Harrison CJ, Tyler R, Smith A, Findlay R, et al. Community-wide vaccination with the heptavalent pneumococcal conjugate significantly alters the microbiology of acute otitis media. Pediatr Infect Dis J 2004; 23:829-33; PMID:15361721; http://dx.doi.org/10.1097/01.inf.0000136868. 91756.80.
3. Casey JR, Adlowitz DG, Pichichero ME. New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine. Pediatr Infect Dis J 2010; 29:304-9; PMID:19935445.
4. Pichichero ME, Casey JR. Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children. JAMA 2007; 298:1772-8; PMID:17940232; http://dx.doi.org/10.1001/jama.298.15.1772.
5. Adamou JE, Heinrichs JH, Erwin AL, Walsh W, Gayle T, Dormitzer M, et al. Identification and characterization of a novel family of pneumococcal proteins that are protective against sepsis. Infect Immun 2001; 69:949-58; PMID:11159990; http://dx.doi.org/10.1128/IAI.69.2.949-58.2001.
6. García P, González MP, García E, López R, García JL. LytB, a novel pneumococcal murein hydrolase essential for cell separation. Mol Microbiol 1999; 31:1275-81; PMID:10096093; http://dx.doi.org/ 10.1046/j.1365-2958.1999.01238.x.
7. Glover DT, Hollingshead SK, Briles DE. Streptococcus pneumoniae surface protein PcpA elicits protection against lung infection and fatal sepsis. Infect Immun 2008; 76:2767-76; PMID:18391008; http://dx.doi.org/10.1128/IAI.01126-07.
8. Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Mol Microbiol 2002; 45:1389-406; PMID:12207705.
9. Marriott HM, Mitchell TJ, Dockrell DH. Pneumolysin: a double-edged sword during the host-pathogen interaction. Curr Mol Med 2008; 8:497-509; PMID:18781957; http://dx.doi.org/10.2174/156652408785747924.
10. Pichichero ME, Kaur R, Casey JR, Sabirov A, Khan N, Almudevar A. Serum Antibody Response to Haemophilus influenzae Outer Membrane Protein P6, OMP26 and Protein D After Nasopharyngeal Colonization and Acute Otitis Media. Vaccine 2010; 28:7184-92; PMID:20800701; http://dx.doi.org/10.1016/j.vaccine.2010.08. 063.
11. http://spneumoniae.mlst.net/misc/info.asp
12. Holmlund E, Quiambao B, Ollgren J, Nohynek H, Käyhty H. Development of natural antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A and pneumolysin in Filipino pregnant women and their infants in relation to pneumococcal carriage. Vaccine 2006; 24:57-65; PMID:16115703; http://dx.doi.org/10.1016/j.vaccine.2005.07.055.
13. Simell B, Ahokas P, Lahdenkari M, Poolman J, Henckaerts I, Kilpi TM, et al. Pneumococcal carriage and acute otitis media induce serum antibodies to pneumococcal surface proteins CbpA and PhtD in children. Vaccine 2009; 27:4615-21; PMID:19524618; http://dx.doi.org/10.1016/j.vaccine.2009.05.071.
14. Holmlund E, Quiambao B, Ollgren J, Jaakkola T, Neyt C, Poolman J, et al. Antibodies to pneumococcal proteins PhtD, CbpA and LytC in Filipino pregnant women and their infants in relation to pneumococcal carriage. Clin Vaccine Immunol 2009; 16:916-23; PMID:19403781; http://dx.doi.org/10.1128/CVI.00050-09.
15. Sabirov A, Casey JR, Murphy TF, Pichichero ME. Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6. Pediatr Res 2009; 66:565-70; PMID:19581824; http://dx.doi.org/10. 1203/PDR.0b013e3181b4f8a6.
16. Samukawa T, Yamanaka N, Hollingshead S, Klingman K, Faden H. Immune responses to specific antigens of Streptococcus pneumoniae and Moraxella catarrhalis in the respiratory tract. Infect Immun 2000; 68:1569-73; PMID:10678976; http://dx.doi.org/10.1128/IAI.68.3.1569-73.2000.
17. Virolainen A, Jero J, Chattopadhyay P, Karma P, Eskola J, Leinonen M. Comparison of serum antibodies to pneumolysin with those to pneumococcal capsular polysaccharides in children with acute otitis media. Pediatr Infect Dis J 1996; 15:128-33; PMID:8822285; http://dx.doi.org/10.1097/00006454-199602000- 00008.
18. Rapola S, Kilpi T, Lahdenkari M, Mäkelä PH, Käyhty H. Antibody response to the pneumococcal proteins pneumococcal surface adhesin A and pneumolysin in children with acute otitis media. Pediatr Infect Dis J 2001; 20:482-7; PMID:11368104; http://dx.doi.org/10.1097/00006454-200105000-00003.
19. Kaur R, Casey JR, Pichichero ME. Serum Antibody Response to Three Non-typeable Haemophilus influenzae Outer Membrane Proteins During Nasopharyngeal Colonization and Acute Otitis Media in Otitis Prone and Non-Prone Children. Vaccine 2011; 29:1023-8; PMID:21129398; http://dx.doi.org/10.1016/j. vaccine.2010.11.055.
20. Kaur R, Casey JR, Pichichero ME. Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitisprone children. Pediatr Infect Dis J 2011; 30:645-50; PMID:21487325; http://dx.doi.org/10.1097/INF.0b013e31821c2d8b.
21. Khan MN, Sharma S, Filkins L, Pichichero ME. PcpA of Streptococcus pneumoniae is a putative adhesin that elicits functional antibodies in humans. Microbes Infect 2012; (In review).
22. Khan MN, Pichichero ME. PhtD and PhtE of Streptococcus pneumoniae are adhesins that elicit functional antibodies in humans. Vaccine 2012 Apr 16;30(18):2900-7. Epub 2012 Feb 17; PMID: 22349524.