Community-wide vaccination with the heptavalent pneumococcal conjugate significantly alters the microbiology of acute otitis media

Pediatric Infectious Disease Journal

Volumn 23, Issue 9, 2004, Pages 829-833

  Block, Stem L ^a   Hedrick, James ^a   Harrison, Christopher J ^b   Tyler, Ron ^a   Smith, Alan ^a   Findlay, Rebecca ^a   Keegan, Eileen ^a  

^a Kentucky Pediatric Research Institute   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

Acute otitis media; Antibiotics; Children; Penicillin resistant Streptococcus pneumoniae; Pneumococcal conjugate vaccine; Pneumococcal serotypes; Streptococcus pneumoniae; Vaccines

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAMASE; PENICILLIN DERIVATIVE; PNEUMOCOCCUS VACCINE; HEPTAVALENT PNEUMOCOCCAL CONJUGATE VACCINE; MENINGOCOCCUS VACCINE; VACCINE;

ARTICLE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CLINICAL ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GRAM NEGATIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; HUMAN; INFANT; MALE; MICROBIOLOGY; OTITIS MEDIA; PRESCHOOL CHILD; PRIORITY JOURNAL; RURAL AREA; STREPTOCOCCUS PNEUMONIAE; UNITED STATES; VACCINATION; ACUTE DISEASE; ANALYSIS OF VARIANCE; COHORT ANALYSIS; COMPARATIVE STUDY; GRAM POSITIVE BACTERIUM; IMMUNIZATION; IMMUNOLOGY; INCIDENCE; ISOLATION AND PURIFICATION; PROBABILITY; PROGNOSIS; PROSPECTIVE STUDY; RISK ASSESSMENT; STANDARD; STREPTOCOCCUS INFECTION;

ACUTE DISEASE; ANALYSIS OF VARIANCE; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; IMMUNIZATION SCHEDULE; INCIDENCE; INFANT; MALE; MENINGOCOCCAL VACCINES; OTITIS MEDIA; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; PROBABILITY; PROGNOSIS; PROSPECTIVE STUDIES; RISK ASSESSMENT; STREPTOCOCCUS PNEUMONIAE; VACCINATION; VACCINES, CONJUGATE;

EID: 6344233426     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.inf.0000136868.91756.80     Document Type: Article

References (18)

1. Eskola J, Kilpi T, Palmu A, et al. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. N Engl J Med. 2001;344:403-409.
2. Fireman B, Black SB, Shinefield HR, Lee J, Lewis E, Ray P. Impact of the pneumococcal conjugate vaccine on otitis media [published correction appears in Pediatr Infect Dis J. 2003;22:163]. Pediatr Infect Dis J. 2003;22:10-16.
3. Fireman B, Black SB, Shinefield HR, Lee J, Lewis E, Ray P. Impact of the pneumococcal conjugate vaccine on otitis media [published correction appears in Pediatr Infect Dis J. 2003;22:163]. Pediatr Infect Dis J. 2003;22:10-16.
4. Black S, Shinefield H, Fireman B, et al. Efficacy, safety, and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Pediatr Infect Dis J. 2000;19:187-195.
5. Dagan R, Fraser D. Conjugate pneumococcal vaccine and antibiotic-resistant Streptococcus pneumonias herd immunity and reduction of otitis morbidity. Pediatr Infect Dis J. 2000;19:S79-S88.
6. Mbelle N, Huebner RE, Waas AD, et al. Immunogenicity and impact on nasopharyngeal carriage of a nonvalent pneumococcal conjugate vaccine. J Infect Dis. 1999;180:1171-1176.
7. Block SL, Hedrick J, Hairison CJ, et al. Pneumococcal serotypes from acute otitis media in rural Kentucky. Pediatr Infect Dis J. 2002;21:859-865.
8. Wald ER, Mason EO, Bradley JS, Barson WJ, Kaplan SL, The US Pediatric Multicenter Pneumococcal Surveillance Group. Acute otitis media caused by Streptococcus pneumoniae in children's hospitals between 1994 and 1997. Pediatr Infect Dis J. 2001;20:34-39.
9. Pelton SI, Klein JO. The promise of immunoprophylaxis for prevention of acute otitis media. Pediatr Infect Dis J. 1999;18:926-935.
10. Block SJ, Hedrick JA, Harrison CJ. Widespread use of conjugated pneumococcal vaccine significantly reduces rates of AOM and antibiotic usage [abstract]. Paper presented at the Meeting of the Society for Pediatric Research; May 2004; San Francisco, CA.
11. Block SL, Harrison CJ, Hedrick J, Tyler R, Smith A, Hedrick R. Restricted use of antibiotic prophylaxis for recurrent acute otitis media in the era of penicillin non-susceptible Streptococcus pneumoniae. Int J Pediatr Otorhinolaryngol 2001;61:47-60.
12. National Committee for Clinical Laboratory Standards. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. 5th ed. Approved Standard, NCCLS Document M7-A5, Vol 20:(2). NCCLS, Villanova, PA: National Committee for Clinical Laboratory Standards; 2000.
13. Jacobs MR, Bajaksouzian S, Zilles A, Lin G, Pankuck GA, Appelbaum PC. Susceptibilities of Streptococcus pneumoniae and Haemophilus influenzas to 10 oral antimicrobial agents based on pharmacodynamic parameters: 1997 U.S.Surveillance Study. Antimicrob Agents Chemother. 1999;43:1901-1098.
14. Jacobs MR. Optimisation of antimicrobial therapy using pharmacokinetic and pharmacodynamic parameters. Clin Microbiol Infect. 2001;11:589-596.
15. American Academy of Pediatrics and American Academy of Family Physicians. Clinical Practice Guidelines: diagnosis and management of acute otitis media. Pediatrics. 2004;113:1451-1465.
16. Piglansky L, Leibovitz E, Raiz S, et al. Bacteriologic and clinical efficacy of high dose amoxicillin for therapy of acute otitis media in children. Pediatr Infect Dis J. 2003;22:405-413.
17. Vakevainen M, Eklund C, Eskola J, Kayhty H. Cross-reactivity of antibodies to type 6B and 6A polysaccharides of Streptococcus pneumoniae, evoked by pneumococcal conjugate vaccines, in infants. J Infect Dis. 2001;184:789-793.
18. Black SB, Shinefield HR, Hansen J, Elvin L, Laufer D, Malinoski F. Postlicensure evaluation of the effectiveness of seven valent pneumococcal conjugate vaccine. Pediatr Infect Dis J. 2001;20:1105-1111.