PreImplantation Factor (PIF) promoting role in embryo implantation: Increases endometrial Integrin-α2β3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua

Reproductive Biology and Endocrinology

Volumn 10, Issue , 2012, Pages

  Barnea, Eytan R ^a,b,c   Kirk, David ^d   Paidas, Michael J ^e  

^a Society for the Investigation of Early Pregnancy (SIEP)   (United States)

^b BioIncept LLC   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^d PharmMedInfo   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Decidua; Endometrium; Gene Expression; Preimplantation Factor (PIF)

Indexed keywords

ALPHA2 BETA3 INTEGRIN; AMPHIREGULIN; BETACELLULIN; EPIREGULIN; FIBROBLAST GROWTH FACTOR; GLYCOPROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 3; PHOSPHOTRANSFERASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DECIDUA; DOWN REGULATION; ENDOMETRIUM CELL; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FEMALE; FERTILIZATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOLECULAR INTERACTION; NIDATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STROMA; UPREGULATION;

AMINO ACID SEQUENCE; BLASTOCYST; CELLS, CULTURED; DECIDUA; DOWN-REGULATION; ENDOMETRIUM; EPIDERMAL GROWTH FACTOR; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLYCOPROTEINS; HUMANS; INTEGRIN ALPHA2; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR SEQUENCE DATA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDES; UP-REGULATION;

EID: 84863676874     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-10-50     Document Type: Article

References (46)

1. Sharma S, Murphy SP, Barnea ER. Genes regulating implantation and fetal development: a focus on mouse knockout models. Front Biosci 2006, 11:2123-2137. 10.2741/1955, 16720299.
2. Singh M, Chaudhry P, Asselin E. Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors. J Endocrinol 2011, 210:5-14. 10.1530/JOE-10-0461, 21372150.
3. Aplin JD, Kimber SJ. Trophoblast-uterine interactions at implantation. Reprod Biol Endocrinol 2004, 2:48. 10.1186/1477-7827-2-48, 471567, 15236654.
4. Barnea ER. Insight into early pregnancy events: the emerging role of the embryo. Am J Reprod Immunol 2004, 51:319-322. 10.1111/j.1600-0897.2004.00159.x, 15212665.
5. Barnea ER, Simon J, Levine SP, Coulam CB, Taliadouros GS, Leavis PC. Progress in characterization of pre-implantation factor in embryo cultures and in vivo. Am J Reprod Immunol 1999, 42:95-99.
6. Coulam CB, Roussev RG, Thomason EJ, Barnea ER. Preimplantation factor (PIF) predicts subsequent pregnancy loss. Am J Reprod Immunol 1995, 34:88-92.
7. Somerset DA, Zheng Y, Kilby MD, Sansom DM, Drayson MT. Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset. Immunology 2004, 112:38-43. 10.1111/j.1365-2567.2004.01869.x, 1782465, 15096182.
8. Barnea ER. Applying embryo-derived immune tolerance to the treatment of immune disorders. Ann N Y Acad Sci 2007, 1110:602-618. 10.1196/annals.1423.064, 17911476.
9. Ledee N, Dubanchet S, Oger P, Meynant C, Lombroso R, Ville Y, Chaouat G. Uterine receptivity and cytokines: new concepts and new applications. Gynecol Obstet Investig 2007, 64:138-143.
10. Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?. Immunol Today 1993, 14:353-356. 10.1016/0167-5699(93)90235-D, 8363725.
11. Sakamoto T, Tanaka T, Umesaki N, Ogita S. Epidermal growth factor inhibits 8-Br-cAMP-induced decidualization of human endometrial stromal cells. Horm Res 2000, 53:294-299. 10.1159/000053186, 11146370.
12. Hess AP, Hamilton AE, Talbi S, Dosiou C, Nyegaard M, Nayak N, Genbecev-Krtolica O, Mavrogianis P, Ferrer K, Kruessel J, et al. Decidual stromal cell response to paracrine signals from the trophoblast: amplification of immune and angiogenic modulators. Biol Reprod 2007, 76:102-117. 10.1095/biolreprod.106.054791, 17021345.
13. Barnea ER. Current progress in early pregnancy investigation and the steps ahead. Early Pregnancy 2000, 4:1-4.
14. Barnea ER, Lahijani KI, Roussev R, Barnea JD, Coulam CB. Use of lymphocyte platelet binding assay for detecting a preimplantation factor: a quantitative assay. Am J Reprod Immunol 1994, 32:133-138.
15. Roussev RG, Barnea ER, Thomason EJ, Coulam CB. A novel bioassay for detection of preimplantation factor (PIF). Am J Reprod Immunol 1995, 33:68-73.
16. Roussev RG, Coulam CB, Barnea ER. Development and validation of an assay for measuring preimplantation factor (PIF) of embryonal origin. Am J Reprod Immunol 1996, 35:281-287. 10.1111/j.1600-0897.1996.tb00046.x, 8962662.
17. Roussev RG, Coulam CB, Kaider BD, Yarkoni M, Leavis PC, Barnea ER. Embryonic origin of preimplantation factor (PIF): biological activity and partial characterization. Mol Hum Reprod 1996, 2:883-887. 10.1093/molehr/2.11.883, 9237230.
18. Barnea ER. The embryo: a privileged entity in a privileged site: lessons learnt from embryonal development. Early Pregnancy 1997, 3:77-80.
19. Stamatkin CW, Roussev RG, Stout M, Coulam CB, Triche E, Godke RA, Barnea ER. Preimplantation Factor (PIF) negates embryo toxicity and promotes embryo development in culture. Reprod Biomed Online 2011, 23(4):517-524. 10.1016/j.rbmo.2011.06.009, 21900046.
20. Stamatkin CW, Roussev RG, Stout M, Absalon-Medina V, Ramu S, Goodman C, Coulam CB, Gilbert RO, Godke RA, Barnea ER. Preimplantation Factor (PIF) correlates with early mammalian embryo development - bovine and murine models. Reprod Biol Endocrinol 2011, 9:63. 10.1186/1477-7827-9-63, 3112407, 21569635.
21. Barnea ER, Kirk D, Ramu S, Rivnay B, Roussev R, Paidas MJ. Preimplantation Factor (PIF) Orchestrates Systemic Anti-inflammatory Response by Immune Cells: A Direct Effect on Peripheral Blood Mononuclear Cells. Am J Obstet Gynecol 2012, in press.
22. Weiss L, Bernstein S, Jones R, Amunugama R, Krizman D, Jebailey L, Almogi-Hazan O, Yekhtin Z, Shiner R, Reibstein I, et al. Preimplantation factor (PIF) analog prevents type I diabetes mellitus (TIDM) development by preserving pancreatic function in NOD mice. Endocrine 2011, 40:41-54. 10.1007/s12020-011-9438-5, 21424847.
23. Weiss L, Or R, Jones RC, Amunugama R, JeBailey L, Ramu S, Bernstein SA, Yekhtin Z, Almogi-Hazan O, Shainer R, et al. Preimplantation Factor (PIF) reverses neuroinflammation while promoting neural repair in EAE model. J Neurol Sci 2011, 312:146-157.
24. Duzyj CM, Barnea ER, Li M, Huang SJ, Krikun G, Paidas MJ. Preimplantation factor promotes first trimester trophoblast invasion. Am J Obstet Gynecol 2010, 203(402):e401-e404.
25. Paidas MJ, Krikun G, Huang SJ, Jones R, Romano M, Annunziato J, Barnea ER. A genomic and proteomic investigation of the impact of preimplantation factor on human decidual cells. Am J Obstet Gynecol 2010, 202(459):e451-e458.
26. Barnea ER. Assays for PreImplantation Factor and PreImplantation Factor Peptides 2007, , United States.
27. Irwin JC, Kirk D, King RJ, Quigley MM, Gwatkin RB. Hormonal regulation of human endometrial stromal cells in culture: an in vitro model for decidualization. Fertil Steril 1989, 52:761-768.
28. Satyaswaroop PG, Bressler RS, de la Pena MM, Gurpide E. Isolation and culture of human endometrial glands. J Clin Endocrinol Metab 1979, 48:639-641. 10.1210/jcem-48-4-639, 429509.
29. Simon C, Piquette GN, Frances A, Westphal LM, Heinrichs WL, Polan ML. Interleukin-1 type I receptor messenger ribonucleic acid expression in human endometrium throughout the menstrual cycle. Fertil Steril 1993, 59:791-796.
30. Gonzalez RR, Palomino A, Boric A, Vega M, Devoto L. A quantitative evaluation of alpha1, alpha4, alphaV and beta3 endometrial integrins of fertile and unexplained infertile women during the menstrual cycle. A flow cytometric appraisal. Hum Reprod 1999, 14:2485-2492. 10.1093/humrep/14.10.2485, 10527974.
31. Dunn CL, Kelly RW, Critchley HO. Decidualization of the human endometrial stromal cell: an enigmatic transformation. Reprod Biomed Online 2003, 7:151-161. 10.1016/S1472-6483(10)61745-2, 14567882.
32. Oommen S, Gupta SK, Vlahakis NE. Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin {alpha}9{beta}1: identification of a specific {alpha}9{beta}1 binding site. J Biol Chem 2010, 286:1083-1092. 3020715, 21071450.
33. Larrieu-Lahargue F, Welm AL, Thomas KR, Li DY. Netrin-4 activates endothelial integrin {alpha}6{beta}1. Circ Res 2011, 109:770-774. 10.1161/CIRCRESAHA.111.247239, 21799154.
34. Gerhardt A, Scharf RE, Mikat-Drozdzynski B, Krussel JS, Bender HG, Zotz RB. The polymorphism of platelet membrane integrin alpha2beta1 (alpha2807TT) is associated with premature onset of fetal loss. Thromb Haemost 2005, 93:124-129.
35. Gnainsky Y, Granot I, Aldo PB, Barash A, Or Y, Schechtman E, Mor G, Dekel N. Local injury of the endometrium induces an inflammatory response that promotes successful implantation. Fertil Steril 2010, 94:2030-2036. 10.1016/j.fertnstert.2010.02.022, 3025806, 20338560.
36. Ben-Ami I, Komsky A, Bern O, Kasterstein E, Komarovsky D, Ron-El R. In vitro maturation of human germinal vesicle-stage oocytes: role of epidermal growth factor-like growth factors in the culture medium. Hum Reprod 2010, 26:76-81.
37. Khatua A, Wang X, Ding T, Zhang Q, Reese J, DeMayo FJ, Paria BC. Indian hedgehog, but not histidine decarboxylase or amphiregulin, is a progesterone-regulated uterine gene in hamsters. Endocrinology 2006, 147:4079-4092. 10.1210/en.2006-0231, 16794005.
38. Anteby EY, Natanson-Yaron S, Hamani Y, Sciaki Y, Goldman-Wohl D, Greenfield C, Ariel I, Yagel S. Fibroblast growth factor-10 and fibroblast growth factor receptors 1-4: expression and peptide localization in human decidua and placenta. Eur J Obstet Gynecol Reprod Biol 2005, 119:27-35. 10.1016/j.ejogrb.2004.05.014, 15734081.
39. Bischof P, Campana A. Molecular mediators of implantation. Baillieres Best Pract Res Clin Obstet Gynaecol 2000, 14:801-814. 10.1053/beog.2000.0120, 11023801.
40. Wong H, Belvin M, Herter S, Hoeflich KP, Murray LJ, Wong L, Choo EF. Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1 H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy. J Pharmacol Exp Ther 2009, 329:360-367. 10.1124/jpet.108.148189, 19147858.
41. Witherow DS, Garrison TR, Miller WE, Lefkowitz RJ. beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. Proc Natl Acad Sci U S A 2004, 101:8603-8607. 10.1073/pnas.0402851101, 423241, 15173580.
42. Pereira SR, Vasconcelos VM, Antunes A. The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins. Crit Rev Toxicol 2011, 41:83-110. 10.3109/10408444.2010.515564, 21288162.
43. Lamprianou S, Chatzopoulou E, Thomas JL, Bouyain S, Harroch S. A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells. Proc Natl Acad Sci U S A 2011, 108:17498-17503. 10.1073/pnas.1108774108, 3198311, 21969550.
44. Fujikawa A, Fukada M, Makioka Y, Suzuki R, Chow JP, Matsumoto M, Noda M. Consensus substrate sequence for protein-tyrosine phosphatase receptor type Z. J Biol Chem 2011, 286:37137-37146. 10.1074/jbc.M111.270140, 21890632.
45. Kashiwagi A, DiGirolamo CM, Kanda Y, Niikura Y, Esmon CT, Hansen TR, Shioda T, Pru JK. The postimplantation embryo differentially regulates endometrial gene expression and decidualization. Endocrinology 2007, 148:4173-4184. 10.1210/en.2007-0268, 17510242.
46. Pan Q, Chegini N. MicroRNA signature and regulatory functions in the endometrium during normal and disease states. Semin Reprod Med 2008, 26:479-493. 10.1055/s-0028-1096128, 2728121, 18951330.