PreImplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: Effect on peripheral blood mononuclear cells

American Journal of Obstetrics and Gynecology

Volumn 207, Issue 4, 2012, Pages 313.e1-313.e11

  Barnea, Eytan R ^a   Kirk, David ^b   Ramu, Sivakumar ^c   Rivnay, Benjamin ^d   Roussev, Roumen ^c   Paidas, Michael J ^e  

^a Society for the Investigation of Early Pregnancy and BioIncept LLC   (United States)

^b PharmMedInfo   (United States)

^c CARI Research Institute   (United States)

^d Repromedix Inc   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

embryo; immune disorder; immune modulation; PreImplantation Factor

Indexed keywords

CD14 ANTIGEN; CD19 ANTIGEN; CD3 ANTIBODY; CD56 ANTIGEN; FLUORESCEIN ISOTHIOCYANATE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 5; PREIMPLANTATION FACTOR; PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; FERTILIZATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNITY; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; LYMPHOCYTE ACTIVATION; MIXED LYMPHOCYTE CULTURE; NATURAL KILLER CELL; NIDATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; TH1 CELL; TH2 CELL; UPREGULATION;

EID: 84866322817     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2012.07.017     Document Type: Article

References (33)

1. S.R. Choudhury, L.A. Knapp Human reproductive failure: I, immunological factors Hum Reprod Update 7 2001 113 134
2. E.R. Barnea Insight into early pregnancy events: the emerging role of the embryo Am J Reprod Immunol 51 2004 319 322
3. E.R. Barnea, S. Sharma Prediction of Implantation in ART using molecular biology G.N. Allahbadia, R. Merchant, Infertility, art and endoscopy 2007 Elsevier Publishers 183 194
4. E.R. Barnea Signaling between embryo and mother in early pregnancy: basis for development of tolerance H.J.A. Carp, Recurrent pregnancy loss 2007 Taylor & Francis London 15 21
5. C. Weber-Schoendorfer, C. Schaefer Multiple sclerosis, immunomodulators, and pregnancy outcome: a prospective observational study Mult Scler 15 2009 1037 1042
6. E.R. Barnea, C.B. Coulam Embryonic signals E. Jauniaux, E. Barnea, R.G. Edwards, Embryonic medicine and therapy 1997 Oxford University Press New York 63 75
7. T.G. Wegmann, H. Lin, L. Guilbert, T.R. Mosmann Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 14 1993 353 356
8. A.L. Mellor, D.H. Munn Extinguishing maternal immune responses during pregnancy: implications for immunosuppression Semin Immunol 13 2001 213 218
9. R. Mattsson, R. Holmdahl, A. Scheynius, F. Bernadotte, A. Mattsson, P.H. Van der Meide Placental MHC class I antigen expression is induced in mice following in vivo treatment with recombinant interferon-gamma J Reprod Immunol 19 1991 115 129
10. A.M. Rogers, I. Boime, J. Connolly, J.R. Cook, J.H. Russell Maternal-fetal tolerance is maintained despite transgene-driven trophoblast expression of MHC class I, and defects in Fas and its ligand Eur J Immunol 28 1998 3479 3487
11. M.J. Paidas, D.H. Ku, B. Davis, C.J. Lockwood, Y.S. Arkel Soluble monocyte cluster domain 163, a new global marker of anti-inflammatory response, is elevated in the first trimester of pregnancy J Thromb Haemost 2 2004 1009 1010
12. J.D. Aplin, S.J. Kimber Trophoblast-uterine interactions at implantation Reprod Biol Endocrinol 2 2004 48
13. I.L. Sargent, A.M. Borzychowski, C.W. Redman NK cells and human pregnancy-an inflammatory view Trends Immunol 27 2006 399 404
14. A. Moffett-King Natural killer cells and pregnancy Nat Rev Immunol 2 2002 656 663
15. S. Sharma, S.P. Murphy, E.R. Barnea Genes regulating implantation and fetal development: a focus on mouse knockout models Front Biosci 11 2006 2123 2137
16. A. Doria, L. Iaccarino, S. Arienti Th2 immune deviation induced by pregnancy: the two faces of autoimmune rheumatic diseases Reprod Toxicol 22 2006 234 241
17. R. Raghupathy Th1-type immunity is incompatible with successful pregnancy Immunol Today 18 1997 478 482
18. M.D. Bates, S. Quenby, K. Takakuwa, P.M. Johnson, G.S. Vince Aberrant cytokine production by peripheral blood mononuclear cells in recurrent pregnancy loss? Hum Reprod 17 2002 2439 2444
19. G. Chaouat, N. Ledee-Bataille, S. Dubanchet, S. Zourbas, O. Sandra, J. Martal TH1/TH2 paradigm in pregnancy: paradigm lost? Cytokines in pregnancy/early abortion: reexamining the TH1/TH2 paradigm Int Arch Allergy Immunol 134 2004 93 119
20. D.A. Somerset, Y. Zheng, M.D. Kilby, D.M. Sansom, M.T. Drayson Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset Immunology 112 2004 38 43
21. E.R. Barnea, K.I. Lahijani, R. Roussev, J.D. Barnea, C.B. Coulam Use of lymphocyte platelet binding assay for detecting a preimplantation factor: a quantitative assay Am J Reprod Immunol 32 1994 133 138
22. R.G. Roussev, C.B. Coulam, B.D. Kaider, M. Yarkoni, P.C. Leavis, E.R. Barnea Embryonic origin of preimplantation factor (PIF): biological activity and partial characterization Mol Hum Reprod 2 1996 883 887
23. E.R. Barnea, J. Simon, S.P. Levine, C.B. Coulam, G.S. Taliadouros, P.C. Leavis Progress in characterization of pre-implantation factor in embryo cultures and in vivo Am J Reprod Immunol 42 1999 95 99
24. N.G. Than, M.J. Paidas, S. Mizutani, S. Sharma, J. Padbury, E.R. Barnea Embryo-placento-maternal interaction and biomarkers: from diagnosis to therapy: a workshop report Placenta 28 suppl 2007 S107 S110
25. E.R. Barnea Applying embryo-derived immune tolerance to the treatment of immune disorders Ann N Y Acad Sci 1110 2007 602 618
26. C.W. Stamatkin, R.G. Roussev, M. Stout Preimplantation Factor (PIF) correlates with early mammalian embryo development - bovine and murine models Reprod Biol Endocrinol 9 2011 63
27. C.W. Stamatkin, R.G. Roussev, M. Stout Preimplantation Factor (PIF) negates embryo toxicity and promotes embryo development in culture Reprod BioMedicine Online 23 2011 517 524
28. M.J. Paidas, G. Krikun, S.J. Huang A genomic and proteomic investigation of the impact of preimplantation factor on human decidual cells Am J Obstet Gynecol 202 2010 459.e1 459.e8
29. C.M. Duzyj, E.R. Barnea, M. Li, S.J. Huang, G. Krikun, M.J. Paidas PreImplantation Factor promotes first trimester trophoblast invasion Am J Obstet Gynecol 203 2010 402.e1 402.e4
30. L. Weiss, S. Bernstein, R. Jones PreImplantation Factor (PIF*) analog prevents type I diabetes mellitus (TIDM) development by preserving pancreatic function in NOD mice Endocrine 40 2011 41 54
31. L. Weiss, R. Or, R.C. Jones PreImplantation Factor reverses neuroinflammation while promoting neural repair in EAE model J Neurol Sci 312 2011 146 157
32. E.R. Barnea Assays for PreImplantation Factor and PreImplantation Factor peptides United States 2007 US7,273,708 www.uspto.gov Accessed Aug. 17, 2012
33. P. Tzonis, D. Moschandreou, T. Keramitsoglou Kinetics of circulating preimplantation factor (PIF) levels during pregnancy J Reprod Immunol 86 2010 42