Isoflurane induces cognitive deficits in the Morris water maze task in rats

European Journal of Anaesthesiology

Volumn 29, Issue 5, 2012, Pages 239-245

  Callaway, Jennifer K ^a   Jones, Nigel C ^a   Royse, Colin F ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Aged rats; Isoflurane; Memory; Postoperative cognitive dysfunction; Water maze

Indexed keywords

ISOFLURANE; OXYGEN;

ANIMAL EXPERIMENT; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EXPOSURE; LEARNING; LONG TERM MEMORY; MALE; MAZE TEST; MEMORY CONSOLIDATION; NONHUMAN; RAT; TASK PERFORMANCE;

AGE FACTORS; ANESTHETICS, INHALATION; ANIMALS; BEHAVIOR, ANIMAL; COGNITION; COGNITION DISORDERS; ISOFLURANE; LEARNING; MALE; MEMORY; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME;

EID: 84863663651     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0b013e32835103c1     Document Type: Article

References (35)

1. Bodolea C, Hagau N, Coman I, et al. Postoperative cognitive dysfunction in elderly patients. An integrated psychological and medical approach. J Cogn Behav Psychother 2008; 8:117-132.
2. Monk TG, Weldon BC, Garvan CW, et al. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology 2008; 108:18-30.
3. Culley DJ, Baxter MG, Yukhananov R, et al. Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats. Anesthesiology 2004; 100:309-314. (Pubitemid 38133698)
4. Culley DJ, Baxter M, Yukhananov R, et al. The memory effects of general anesthesia persist for weeks in young and aged rats. Anesth Analg 2003; 96:1004-1009. (Pubitemid 36359033)
5. Crosby C, Culley DJ, Baxter MG, et al. Spatial memory performance weeks after general anesthesia in adult rats. Anesth Analg 2005; 101:1389-1392. (Pubitemid 41531876)
6. Stratmann G, Sall JW, May LDV, et al. Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats. Anesthesiology 2009; 110:834-848.
7. Rammes G, Starker LK, Haseneder R, et al. Isoflurane anaesthesia reversibly improves cognitive function and long-term potentiation (LTP) via an up-regulation in NMDA receptor 2B subunit expression. Neuropharmacology 2009; 56:626-636.
8. Zhu C, Goa J, Karlsson N, et al. Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult, rodents. J Cereb Blood Flow Metab 2010; 30:1017-10130.
9. Rasmussen LS, Larsen K, Houx P, et al. The assessment of postoperative cognitive function. Acta Anaesthesiol Scand 2001; 45:275-289. (Pubitemid 32187530)
10. Culley DJ, Baxter MG, Crosby CA, et al. Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats. Anesth Analg 2004; 99:1393-1397. (Pubitemid 39407286)
11. Culley DJ, Baxter MG, Yukhananov R, et al. Lasting impairment of spatial memory acquisition after general anesthesia in aged rats. J Am Geriatr Soc 2003; 51:571.
12. Morris R. Developments of water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984; 11:47-60. (Pubitemid 14088970)
13. Jones NC, Kumar G, O'Brien TJ, et al. Anxiolytic effects of rapid amygdala kindling, and the influence of early life experience in rats. Behav Brain Res 2009; 203:81-87.
14. Culley DJ, Raghavan SV, Waly M, et al. Nitrous oxide decreases cortical methionine synthase transiently but produces lasting memory impairment in aged rats. Anesth Analg 2007; 105:83-88. (Pubitemid 46975852)
15. Jevtovic-Todorovic V, Hartman RE, Izumi Y, et al. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 2003; 23:876-882. (Pubitemid 36206178)
16. Johnson SA, Young C, Olney JW. Isoflurane-induced neuroapoptosis in the developing brain of nonhypoglycemic mice. J Neurosurg Anesthesiol 2008; 20:21-28. (Pubitemid 351628035)
17. Wise-Faberowski L, Zhang HT, Ing R, et al. Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures. Anesth Analg 2005; 101:651-657. (Pubitemid 41208489)
18. Simon W, Hapfelmeier G, Kochs E, et al. Isoflurane blocks synaptic plasticity in the mouse hippocampus. Anesthesiology 2001; 94:1058-1065. (Pubitemid 32506135)
19. Li Y, Liang G, Wang S, et al. Effects of fetal exposure to isoflurane on postnatal memory and learning in rats. Neuropharmacology 2007; 53:942-950. (Pubitemid 350137388)
20. Loepke AW, Istaphanous GK, McAuliffe JJ, et al. The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory. Anesth Analg 2009; 108:90-104.
21. Whishaw IQ, Cassel JC, Jarrad LE. Rats with fimbria-fornix lesions display a place response in a swimming pool: a dissociation between getting there and knowing where. J Neurosci 1995; 15:5779-5788.
22. Zhang Q, Lu G, Xu Z, et al. Molecular mechanisms and the role of the protein kinase pathway in rat spatial memory impairment following isoflurane anesthesia. Neural Regen Res 2010; 5:508-513.
23. Barnes CA. Review: ageing and the physiology of spatial memory. Neurobiol Aging 1988; 150:580-587.
24. Gallagher M, Pelleymounter MA. Spatial learning deficits in old rats: a model for memory decline in the aged. Neurobiol Aging 1988; 9:549-556. (Pubitemid 19264144)
25. Gallagher M, Burwell RD. Relationship of age-related decline across several behavioural domains. Neurobiol Aging 1989; 10:691-708. (Pubitemid 20059503)
26. Begega A, Cienfuegos S, Rubio S, et al. Effects of aging on the allocentric and egocentric spatial strategies in the Wistar rat. Behav Processes 2001; 53:75-85. (Pubitemid 32194604)
27. Xie ZC, Dong YL, Maeda U, et al. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology 2006; 104:988-994.
28. Xie ZC, Dong YL, Maeda U, et al. Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. J Gerontol A Biol Sci Med Sci 2006; 61:1300-1306. (Pubitemid 46147786)
29. Xie ZC, Dong YL, Maeda U, et al. The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci 2007; 27:1247-1254.
30. Zhang GH, Dong YL, Zhang B, et al. Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci 2008; 28:4551-4560.
31. Wu X, Lu Y, Dong Y, et al. The inhalation anesthetic isoflurane increases levels of pro-inflammatory TNF-a, IL-6 and IL-1b. Neurobiol Aging 2011. [Epub ahead of print]
32. Horn T, Klein J. Lactate levels in the brain are elevated upon exposure to volatile anesthetics: a microdialysis study. Neurochem Int 2010; 57:940-947.
33. Suzuki A, Stern SA, Bozdagi O, et al. Astrocyte-neuron lactate transport is required for long-term memory formation. Cell 2011; 144:810-823.
34. Haseneder R, Kratzer S, vonMeyer L, et al. Isoflurane and sevoflurane dosedependently impair hippocampal long-term potentiation. Eur J Pharmacol 2009; 623:47-51.
35. Alkire MT, Nathan SV, McReynolds JR. Memory enhancing effect of lowdose sevoflurane does not occur in basolateral amygdala-lesioned rats. Anesthesiology 2005; 103:1167-1173. (Pubitemid 41692499)