-
1
-
-
79959866409
-
Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network
-
Audrito V, Vaisitti T, Rossi D, Gottardi D, D'Arena G, Laurenti L, Gaidano G, Malavasi F, Deaglio S,. 2011. Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network. Cancer Res 71: 4473-4483.
-
(2011)
Cancer Res
, vol.71
, pp. 4473-4483
-
-
Audrito, V.1
Vaisitti, T.2
Rossi, D.3
Gottardi, D.4
D'Arena, G.5
Laurenti, L.6
Gaidano, G.7
Malavasi, F.8
Deaglio, S.9
-
2
-
-
50149110590
-
Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage
-
Berman SD, Calo E, Landman AS, Danielian PS, Miller ES, West JC, Fonhoue BD, Caron A, Bronson R, Bouxsein ML, Mukherjee S, Lees JA,. 2008. Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage. Proc Natl Acad Sci USA 105: 11851-11856.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 11851-11856
-
-
Berman, S.D.1
Calo, E.2
Landman, A.S.3
Danielian, P.S.4
Miller, E.S.5
West, J.C.6
Fonhoue, B.D.7
Caron, A.8
Bronson, R.9
Bouxsein, M.L.10
Mukherjee, S.11
Lees, J.A.12
-
3
-
-
34249817549
-
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
-
Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, Feldmann G, Yamakuchi M, Ferlito M, Lowenstein CJ, Arking DE, Beer MA, Maitra A, Mendell JT,. 2007. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 26: 745-752.
-
(2007)
Mol Cell
, vol.26
, pp. 745-752
-
-
Chang, T.C.1
Wentzel, E.A.2
Kent, O.A.3
Ramachandran, K.4
Mullendore, M.5
Lee, K.H.6
Feldmann, G.7
Yamakuchi, M.8
Ferlito, M.9
Lowenstein, C.J.10
Arking, D.E.11
Beer, M.A.12
Maitra, A.13
Mendell, J.T.14
-
4
-
-
28844474597
-
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
-
Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L,. 2005. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem 280: 40364-40374.
-
(2005)
J Biol Chem
, vol.280
, pp. 40364-40374
-
-
Chen, J.1
Zhou, Y.2
Mueller-Steiner, S.3
Chen, L.F.4
Kwon, H.5
Yi, S.6
Mucke, L.7
Gan, L.8
-
5
-
-
0037011056
-
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB
-
Chen LF, Mu Y, Greene WC,. 2002. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J 21: 6539-6548.
-
(2002)
EMBO J
, vol.21
, pp. 6539-6548
-
-
Chen, L.F.1
Mu, Y.2
Greene, W.C.3
-
6
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
Fearon ER, Vogelstein B,. 1990. A genetic model for colorectal tumorigenesis. Cell 61: 759-767.
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
7
-
-
54449092239
-
Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells
-
Fujita Y, Kojima K, Hamada N, Ohhashi R, Akao Y, Nozawa Y, Deguchi T, Ito M,. 2008. Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells. Biochem Biophys Res Commun 377: 114-119.
-
(2008)
Biochem Biophys Res Commun
, vol.377
, pp. 114-119
-
-
Fujita, Y.1
Kojima, K.2
Hamada, N.3
Ohhashi, R.4
Akao, Y.5
Nozawa, Y.6
Deguchi, T.7
Ito, M.8
-
8
-
-
0035988406
-
Prevention of cytokine-induced apoptosis by insulin-like growth factor-I is independent of cell adhesion molecules in HT29-D4 colon carcinoma cells-evidence for a NF-kappaB-dependent survival mechanism
-
Garrouste F, Remacle-Bonnet M, Fauriat C, Marvaldi J, Luis J, Pommier G,. 2002. Prevention of cytokine-induced apoptosis by insulin-like growth factor-I is independent of cell adhesion molecules in HT29-D4 colon carcinoma cells-evidence for a NF-kappaB-dependent survival mechanism. Cell Death Differ 9: 768-779.
-
(2002)
Cell Death Differ
, vol.9
, pp. 768-779
-
-
Garrouste, F.1
Remacle-Bonnet, M.2
Fauriat, C.3
Marvaldi, J.4
Luis, J.5
Pommier, G.6
-
9
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA,. 2000. The hallmarks of cancer. Cell 100: 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
10
-
-
0036009115
-
NF-kappaB at the crossroads of life and death
-
Karin M, Lin A,. 2002. NF-kappaB at the crossroads of life and death. Nat Immunol 3: 221-227.
-
(2002)
Nat Immunol
, vol.3
, pp. 221-227
-
-
Karin, M.1
Lin, A.2
-
11
-
-
0037462725
-
Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65
-
Kiernan R, Bres V, Ng RW, Coudart MP, El Messaoudi S, Sardet C, Jin DY, Emiliani S, Benkirane M,. 2003. Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65. J Biol Chem 278: 2758-2766.
-
(2003)
J Biol Chem
, vol.278
, pp. 2758-2766
-
-
Kiernan, R.1
Bres, V.2
Ng, R.W.3
Coudart, M.P.4
El Messaoudi, S.5
Sardet, C.6
Jin, D.Y.7
Emiliani, S.8
Benkirane, M.9
-
12
-
-
47949096781
-
Cancer-related inflammation
-
Mantovani A, Allavena P, Sica A, Balkwill F,. 2008. Cancer-related inflammation. Nature 454: 436-444.
-
(2008)
Nature
, vol.454
, pp. 436-444
-
-
Mantovani, A.1
Allavena, P.2
Sica, A.3
Balkwill, F.4
-
13
-
-
77956819785
-
Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemia
-
Merkel O, Asslaber D, Pinon JD, Egle A, Greil R,. 2010. Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemia. Cell Cycle 9: 2764-2768.
-
(2010)
Cell Cycle
, vol.9
, pp. 2764-2768
-
-
Merkel, O.1
Asslaber, D.2
Pinon, J.D.3
Egle, A.4
Greil, R.5
-
14
-
-
34249083199
-
Sirtuins in mammals: Insights into their biological function
-
Michan S, Sinclair D,. 2007. Sirtuins in mammals: Insights into their biological function. Biochem J 404: 1-13.
-
(2007)
Biochem J
, vol.404
, pp. 1-13
-
-
Michan, S.1
Sinclair, D.2
-
15
-
-
41649091906
-
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
-
Park SM, Gaur AB, Lengyel E, Peter ME,. 2008. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 22: 894-907.
-
(2008)
Genes Dev
, vol.22
, pp. 894-907
-
-
Park, S.M.1
Gaur, A.B.2
Lengyel, E.3
Peter, M.E.4
-
16
-
-
79955661471
-
Mammalian Sirt1: Insights on its biological functions
-
Rahman S, Islam R,. 2011. Mammalian Sirt1: Insights on its biological functions. Cell Commun Signal 9: 11.
-
(2011)
Cell Commun Signal
, vol.9
, pp. 11
-
-
Rahman, S.1
Islam, R.2
-
17
-
-
42649146208
-
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
-
Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I,. 2008. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 177: 861-870.
-
(2008)
Am J Respir Crit Care Med
, vol.177
, pp. 861-870
-
-
Rajendrasozhan, S.1
Yang, S.R.2
Kinnula, V.L.3
Rahman, I.4
-
18
-
-
34249822779
-
Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
-
Raver-Shapira N, Marciano E, Meiri E, Spector Y, Rosenfeld N, Moskovits N, Bentwich Z, Oren M,. 2007. Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 26: 731-743.
-
(2007)
Mol Cell
, vol.26
, pp. 731-743
-
-
Raver-Shapira, N.1
Marciano, E.2
Meiri, E.3
Spector, Y.4
Rosenfeld, N.5
Moskovits, N.6
Bentwich, Z.7
Oren, M.8
-
19
-
-
34547875773
-
Sirtuins: Critical regulators at the crossroads between cancer and aging
-
Saunders LR, Verdin E,. 2007. Sirtuins: Critical regulators at the crossroads between cancer and aging. Oncogene 26: 5489-5504.
-
(2007)
Oncogene
, vol.26
, pp. 5489-5504
-
-
Saunders, L.R.1
Verdin, E.2
-
20
-
-
79957891891
-
Myc overexpression brings out unexpected antiapoptotic effects of miR-34a
-
Sotillo E, Laver T, Mellert H, Schelter JM, Cleary MA, McMahon S, Thomas-Tikhonenko A,. 2011. Myc overexpression brings out unexpected antiapoptotic effects of miR-34a. Oncogene 30: 2587-2594.
-
(2011)
Oncogene
, vol.30
, pp. 2587-2594
-
-
Sotillo, E.1
Laver, T.2
Mellert, H.3
Schelter, J.M.4
Cleary, M.A.5
McMahon, S.6
Thomas-Tikhonenko, A.7
-
21
-
-
42049092138
-
Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest
-
Sun F, Fu H, Liu Q, Tie Y, Zhu J, Xing R, Sun Z, Zheng X,. 2008. Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest. FEBS Lett 582: 1564-1568.
-
(2008)
FEBS Lett
, vol.582
, pp. 1564-1568
-
-
Sun, F.1
Fu, H.2
Liu, Q.3
Tie, Y.4
Zhu, J.5
Xing, R.6
Sun, Z.7
Zheng, X.8
-
22
-
-
67349151662
-
Inhibition of NFkappaB by activated c-Jun NH2 terminal kinase 1 acts as a switch for C2C12 cell death under excessive stretch
-
Tan J, Kuang W, Jin Z, Jin F, Xu L, Yu Q, Kong L, Zeng G, Yuan X, Duan Y,. 2009. Inhibition of NFkappaB by activated c-Jun NH2 terminal kinase 1 acts as a switch for C2C12 cell death under excessive stretch. Apoptosis 14: 764-770.
-
(2009)
Apoptosis
, vol.14
, pp. 764-770
-
-
Tan, J.1
Kuang, W.2
Jin, Z.3
Jin, F.4
Xu, L.5
Yu, Q.6
Kong, L.7
Zeng, G.8
Yuan, X.9
Duan, Y.10
-
23
-
-
34848868157
-
Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
-
Tazawa H, Tsuchiya N, Izumiya M, Nakagama H,. 2007. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci USA 104: 15472-15477.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 15472-15477
-
-
Tazawa, H.1
Tsuchiya, N.2
Izumiya, M.3
Nakagama, H.4
-
24
-
-
43749113595
-
Modulation of miRNA activity in human cancer: A new paradigm for cancer gene therapy?
-
Tong AW, Nemunaitis J,. 2008. Modulation of miRNA activity in human cancer: A new paradigm for cancer gene therapy? Cancer Gene Ther 15: 341-355.
-
(2008)
Cancer Gene Ther
, vol.15
, pp. 341-355
-
-
Tong, A.W.1
Nemunaitis, J.2
-
25
-
-
70349558133
-
MiR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation
-
Wang X, Liu P, Zhu H, Xu Y, Ma C, Dai X, Huang L, Liu Y, Zhang L, Qin C,. 2009. miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Res Bull 80: 268-273.
-
(2009)
Brain Res Bull
, vol.80
, pp. 268-273
-
-
Wang, X.1
Liu, P.2
Zhu, H.3
Xu, Y.4
Ma, C.5
Dai, X.6
Huang, L.7
Liu, Y.8
Zhang, L.9
Qin, C.10
-
26
-
-
84887212582
-
Oscillations of the p53-Akt network: Implications on cell survival and death
-
Wee KB, Surana U, Aguda BD,. 2009. Oscillations of the p53-Akt network: Implications on cell survival and death. PLoS One 4: e4407.
-
(2009)
PLoS One
, vol.4
-
-
Wee, K.B.1
Surana, U.2
Aguda, B.D.3
-
27
-
-
51349157982
-
The MYCN oncogene is a direct target of miR-34a
-
Wei JS, Song YK, Durinck S, Chen QR, Cheuk AT, Tsang P, Zhang Q, Thiele CJ, Slack A, Shohet J, Khan J,. 2008. The MYCN oncogene is a direct target of miR-34a. Oncogene 27: 5204-5213.
-
(2008)
Oncogene
, vol.27
, pp. 5204-5213
-
-
Wei, J.S.1
Song, Y.K.2
Durinck, S.3
Chen, Q.R.4
Cheuk, A.T.5
Tsang, P.6
Zhang, Q.7
Thiele, C.J.8
Slack, A.9
Shohet, J.10
Khan, J.11
-
29
-
-
62449117918
-
MiR-34, SIRT1 and p53: The feedback loop
-
Yamakuchi M, Lowenstein CJ,. 2009. MiR-34, SIRT1 and p53: The feedback loop. Cell Cycle 8: 712-715.
-
(2009)
Cell Cycle
, vol.8
, pp. 712-715
-
-
Yamakuchi, M.1
Lowenstein, C.J.2
-
30
-
-
33847060910
-
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: Implications for chronic inflammation and aging
-
Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I,. 2007. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: Implications for chronic inflammation and aging. Am J Physiol Lung Cell Mol Physiol 292: L567-L576.
-
(2007)
Am J Physiol Lung Cell Mol Physiol
, vol.292
-
-
Yang, S.R.1
Wright, J.2
Bauter, M.3
Seweryniak, K.4
Kode, A.5
Rahman, I.6
-
31
-
-
3242719545
-
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
-
Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW,. 2004. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23: 2369-2380.
-
(2004)
EMBO J
, vol.23
, pp. 2369-2380
-
-
Yeung, F.1
Hoberg, J.E.2
Ramsey, C.S.3
Keller, M.D.4
Jones, D.R.5
Frye, R.A.6
Mayo, M.W.7
-
32
-
-
77953457652
-
MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1
-
Zhao T, Li J, Chen AF,. 2010. MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1. Am J Physiol Endocrinol Metab 299: E110-E116.
-
(2010)
Am J Physiol Endocrinol Metab
, vol.299
-
-
Zhao, T.1
Li, J.2
Chen, A.F.3
|