Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide

Medical Gas Research

Volumn 1, Issue 1, 2011, Pages

  Hanaoka, Teruyasu ^a,b   Kamimura, Naomi ^a   Yokota, Takashi ^a   Takai, Shinro ^b   Ohta, Shigeo ^b  

^a Department of Biochemistry and Cell Biology Institute of Development and Aging Sciences Graduate School of Medicine   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; COLLAGENASE 3; HYDROGEN; MESSENGER RNA; N ACETYL S NITROSOPENICILLAMINE; STROMELYSIN;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL COUNT; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; GENE EXPRESSION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; UPREGULATION;

EID: 84863648677     PISSN: None     EISSN: 20459912     Source Type: Journal    
DOI: 10.1186/2045-9912-1-18     Document Type: Article

References (42)

1. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S, Nat Med 2007 13 688 694 10.1038/nm1577 17486089 (Pubitemid 46889750)
2. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Fukuda K, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S, Biochem Biophys Res Commun 2007 361 670 674 10.1016/j.bbrc.2007.07.088 17673169 (Pubitemid 47238041)
3. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Ohsawa I, Nishimaki K, Yamagata K, Ishikawa M, Ohta S, Biochem Biophys Res Commun 2008 377 1195 1198 10.1016/j.bbrc.2008.10.156 18996093
4. Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Kajiya M, Silva MJ, Sato K, Ouhara K, Kawai T, Biochem Biophys Res Commun 2009 386 11 15 10.1016/j.bbrc.2009.05.117 19486890
5. Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Kajiya M, Sato K, Silva MJ, Ouhara K, Do PM, Shanmugam KT, Kawai T, Biochem Biophys Res Commun 2009 386 316 321 10.1016/j.bbrc.2009.06.024 19523450
6. Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Itoh T, Fujita Y, Ito M, Masuda A, Ohno K, Ichihara M, Kojima T, Nozawa Y, Biochem Biophys Res Commun 2009 389 651 656 10.1016/j.bbrc.2009.09.047 19766097
7. Recent advances in hydrogen research as a therapeutic medical gas. Huang CS, Kawamura T, Toyoda Y, Nakao A, Free Radic Res 2010 44 971 982 10.3109/10715762.2010.500328 20815764
8. Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases. Ohta S, Biochim Biophys Acta 2011
9. Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications. Ohta S, Curr Pharm Des 2011
10. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S, Neuropsychopharmacology 2009 34 501 508 10.1038/npp.2008.95 18563058
11. Oral hydrogen water prevents chronic allograft nephropathy in rats. Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry KR, Billiar TR, Nakao A, Kidney Int 2010 77 101 109 10.1038/ki.2009.421 19907413
12. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Fu Y, Ito M, Fujita Y, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, Ohsawa I, Ohta S, Ohno K, Neurosci Lett 2009 453 81 85 10.1016/j.neulet.2009.02. 016 19356598
13. Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S, Cancer Chemother Pharmacol 2009 64 753 761 10.1007/s00280-008-0924-2 19148645
14. Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, Noda M, PLoS One 2009 4 7247 10.1371/journal.pone.0007247 19789628
15. Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Kamimura N, Nishimaki K, Ohsawa I, Ohta S, Obesity 2011
16. Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Xie K, Yu Y, Pei Y, Hou L, Chen S, Xiong L, Wang G, Shock 2010 34 90 97 19997046
17. Hydrogen inhalation ameliorates ventilator-induced lung injury. Huang CS, Kawamura T, Lee S, Tochigi N, Shigemura N, Buchholz BM, Kloke JD, Billiar TR, Toyoda Y, Nakao A, Crit Care 2010 14 234 10.1186/cc9389 21184683
18. The reaction of no with superoxide. Huie RE, Padmaja S, Free Radic Res Commun 1993 18 195 199 10.3109/10715769309145868 8396550
19. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA, Proc Natl Acad Sci USA 1990 87 1620 1624 10.1073/pnas.87.4.1620 2154753
20. Nitric oxide and peroxynitrite in health and disease. Pacher P, Beckman JS, Liaudet L, Physiol Rev 2007 87 315 424 10.1152/physrev.00029.2006 17237348 (Pubitemid 46217686)
21. Peroxynitrite signaling: receptor tyrosine kinases and activation of stress-responsive pathways. Klotz LO, Schroeder P, Sies H, Free Radic Biol Med 2002 33 737 743 10.1016/S0891-5849(02)00892-4 12208362 (Pubitemid 35232309)
22. Transduction of anti-apoptotic proteins into chondrocytes in cartilage slice culture. Ozaki D, Sudo K, Asoh S, Yamagata K, Ito H, Ohta S, Biochem Biophys Res Commun 2004 313 522 527 10.1016/j.bbrc.2003.11.144 14697220 (Pubitemid 38021859)
23. The anti-cell death FNK protein protects cells from death induced by freezing and thawing. Sudo K, Asoh S, Ohsawa I, Ozaki D, Yamagata K, Ito H, Ohta S, Biochem Biophys Res Commun 2005 330 850 856 10.1016/j.bbrc.2005.03.059 15809074 (Pubitemid 40462164)
24. The role of reactive oxygen species in homeostasis and degradation of cartilage. Henrotin YE, Bruckner P, Pujol JP, Osteoarthritis Cartilage 2003 11 747 755 10.1016/S1063-4584(03)00150-X 13129694 (Pubitemid 37184493)
25. Pathobiology of osteoarthritis: pathomechanisms and potential therapeutic targets. Roach HI, Aigner T, Soder S, Haag J, Welkerling H, Curr Drug Targets 2007 8 271 282 10.2174/138945007779940160 17305505
26. Osteoarthritis and therapy. Ge Z, Hu Y, Heng BC, Yang Z, Ouyang H, Lee EH, Cao T, Arthritis Rheum 2006 55 493 500 10.1002/art.21994 16739189 (Pubitemid 43887035)
27. Oxygen radicals, nitric oxide and human inflammatory joint disease. Halliwell B, Ann Rheum Dis 1995 54 505 510 10.1136/ard.54.6.505 7632097
28. Oxygen and reactive oxygen species in cartilage degradation: friends or foes? Henrotin Y, Kurz B, Aigner T, Osteoarthritis Cartilage 2005 13 643 654 10.1016/j.joca.2005.04.002 15936958 (Pubitemid 41025117)
29. The chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules. Muir H, Bioessays 1995 17 1039 1048 10.1002/bies.950171208 8634065 (Pubitemid 3009484)
30. Chondrocyte apoptosis induced by nitric oxide. Blanco FJ, Ochs RL, Schwarz H, Lotz M, Am J Pathol 1995 146 75 85 7856740
31. Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. Del Carlo M, Loeser RF, Arthritis Rheum 2002 46 394 403 10.1002/art.10056 11840442 (Pubitemid 34136577)
32. The spread of cell death from impact damaged cartilage: lack of evidence for the role of nitric oxide and caspases. Clements KM, Burton-Wurster N, Lust G, Osteoarthritis Cartilage 2004 12 577 585 10.1016/j.joca.2004.04.006 15219573 (Pubitemid 38950268)
33. Peroxynitrite mediates calcium-dependent mitochondrial dysfunction and cell death via activation of calpains. Whiteman M, Armstrong JS, Cheung NS, Siau JL, Rose P, Schantz JT, Jones DP, Halliwell B, FASEB J 2004 18 1395 1397 15240564 (Pubitemid 39561592)
34. Beneficial effects of GW274150, a novel, potent and selective inhibitor of iNOS activity, in a rodent model of collagen-induced arthritis. Cuzzocrea S, Chatterjee PK, Mazzon E, McDonald MC, Dugo L, Di Paola R, Serraino I, Britti D, Caputi AP, Thiemermann C, Eur J Pharmacol 2002 453 119 129 10.1016/S0014- 2999(02)02338-5 12393067 (Pubitemid 35232462)
35. Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase. Szabo C, Virag L, Cuzzocrea S, Scott GS, Hake P, O'Connor MP, Zingarelli B, Salzman A, Kun E, Proc Natl Acad Sci USA 1998 95 3867 3872 10.1073/pnas.95.7.3867 9520459 (Pubitemid 28173220)
36. Association between the expression of inducible nitric oxide synthase by chondrocytes and its nitric oxide-generating activity in adjuvant arthritis in rats. Yonekura Y, Koshiishi I, Yamada K, Mori A, Uchida S, Nakamura T, Utsumi H, Nitric Oxide 2003 8 164 169 10.1016/S1089-8603(03)00025-9 12826065 (Pubitemid 36765449)
37. Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1. Loeser RF, Carlson CS, Del Carlo M, Cole A, Arthritis Rheum 2002 46 2349 2357 10.1002/art.10496 12355482
38. Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients. Kaur H, Halliwell B, FEBS Lett 1994 350 9 12 10.1016/0014-5793(94) 00722-5 8062931 (Pubitemid 24261386)
39. Distribution of protein nitrotyrosine in synovial tissues of patients with rheumatoid arthritis and osteoarthritis. Sandhu JK, Robertson S, Birnboim HC, Goldstein R, J Rheumatol 2003 30 1173 1181 12784386 (Pubitemid 36666337)
40. Osteoarthritis and nitric oxide. Abramson SB, Osteoarthritis Cartilage 2008 16 Suppl 2 15 20 18794013
41. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, Makino S, Ohta S, Ogawa S, Fukuda K, Biochem Biophys Res Commun 2008 373 30 35 10.1016/j.bbrc.2008.05.165 18541148
42. Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. Oharazawa H, Igarashi T, Yokota T, Fujii H, Suzuki H, Machide M, Takahashi H, Ohta S, Ohsawa I, Invest Ophthalmol Vis Sci 2010 51 487 492 10.1167/iovs.09-4089 19834032