Identification and characterization of tropomyosin 3 associated with granulin-epithelin precursor in human hepatocellular carcinoma

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Lam, Ching Yan ^a,d   Yip, Chi Wai ^a   Poon, Terence C W ^c   Cheng, Christine K C ^a   Ng, Eddy W Y ^c   Wong, Nicholas C L ^a   Cheung, Phyllis F Y ^a   Lai, Paul B S ^c   Ng, Irene O L ^a,b   Fan, Sheung Tat ^a,b   Cheung, Siu Tim ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b THE UNIVERSITY OF HONG KONG   (Hong Kong)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d DEPARTMENT OF HEALTH   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROGRANULIN; TROPOMYOSIN; TROPOMYOSIN 3; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; CANCER CELL; CANCER SURVIVAL; CASE REPORT; CHILD; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LIVER CELL CARCINOMA; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; RECURRENCE FREE SURVIVAL; SCHOOL CHILD; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS; WESTERN BLOTTING;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOPLASM; DISEASE-FREE SURVIVAL; GENE EXPRESSION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; NEOPLASM RECURRENCE, LOCAL; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN PRECURSORS; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; TROPOMYOSIN;

EID: 84863646269     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040324     Document Type: Article

References (37)

1. El-Serag HB, Rudolph KL, (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557-2576.
2. El-Serag HB, Marrero JA, Rudolph L, Reddy KR, (2008) Diagnosis and treatment of hepatocellular carcinoma. Gastroenterology 134: 1752-1763.
3. Wysocki PJ, (2010) Targeted therapy of hepatocellular cancer. Expert Opin Investig Drugs 19: 265-274.
4. Chen X, Cheung ST, So S, Fan ST, Barry C, et al. (2002) Mol Biol Cell 13: 1929-1939.
5. Cheung ST, Chen X, Guan XY, Wong SY, Tai LS, et al. (2002) Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumor. Cancer Res 62: 4711-4721.
6. Cheung ST, Wong SY, Leung KL, Chen X, So S, et al. (2004) Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma. Clin Cancer Res 10: 7629-7636.
7. Cheung ST, Cheung PF, Cheng CK, Wong NC, Fan ST, (2011) Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance. Gastroenterology 140: 344-355.
8. Ho JC, Ip YC, Cheung ST, Lee YT, Chan KF, et al. (2008) Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. Hepatology 47: 1524-1532.
9. Bateman A, Bennett HP, (2009) The granulin gene family: from cancer to dementia. Bioessays 31: 1245-1254.
10. Hoque M, Tian B, Mathews MB, Pe'ery T, (2005) Granulin and granulin repeats interact with the Tat.P-TEFb complex and inhibit Tat transactivation. J Biol Chem 280: 13648-13657.
11. Xu K, Zhang Y, Ilalov K, Carlson CS, Feng JQ, et al. (2007) Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation. J Biol Chem 282: 11347-11355.
12. Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, et al. (2011) The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 332: 478-484.
13. Culouscou JM, Carlton GW, Shoyab M, (1993) Biochemical analysis of the epithelin receptor. J Biol Chem 268: 10458-10462.
14. Xia X, Serrero G, (1998) Identification of cell surface binding sites for PC-cell-derived growth factor, PCDGF, (epithelin/granulin precursor) on epithelial cells and fibroblasts. Biochem Biophys Res Commun 245: 539-543.
15. Ng PC, Ang IL, Chiu RW, Li K, Lam HS, et al. (2010) Host-response biomarkers for diagnosis of late-onset septicemia and necrotizing enterocolitis in preterm infants. J Clin Invest 120: 2989-3000.
16. Wang CL, Coluccio LM, (2010) New insights into the regulation of the actin cytoskeleton by tropomyosin. Int Rev Cell Mol Biol 281: 91-128.
17. Perry SV, (2001) Vertebrate tropomyosin: distribution, properties and function. J Muscle Res Cell Motil 22: 5-49.
18. Pittenger MF, Kazzaz JA, Helfman DM, (1994) Functional properties of non-muscle tropomyosin isoforms. Curr Opin Cell Biol 6: 96-104.
19. Cooley BC, Bergtrom G, (2001) Multiple combinations of alternatively spliced exons in rat tropomyosin-alpha gene mRNA: evidence for 20 new isoforms in adult tissues and cultured cells. Arch Biochem Biophys 390: 71-77.
20. Schevzov G, Vrhovski B, Bryce NS, Elmir S, Qiu MR, et al. (2005) Tissue-specific tropomyosin isoform composition. J Histochem Cytochem 53: 557-570.
21. Lin CS, Leavitt J, (1988) Cloning and characterization of a cDNA encoding transformation-sensitive tropomyosin isoform 3 from tumorigenic human fibroblasts. Mol Cell Biol 8: 160-168.
22. MacLeod AR, Houlker C, Reinach FC, Talbot K, (1986) The mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskeletal tropomyosin. Nucleic Acids Res 14: 8413-8426.
23. Pelham RJ, Lin JJ, Wang YL, (1996) A high molecular mass non-muscle tropomyosin isoform stimulates retrograde organelle transport. J Cell Sci 109: 981-989.
24. Warren KS, Lin JL, McDermott JP, Lin JJ, (1995) Forced expression of chimeric human fibroblast tropomyosin mutants affects cytokinesis. J Cell Biol 129: 697-708.
25. Kim TM, Yim SH, Shin SH, Xu HD, Jung YC, et al. (2008) Clinical implication of recurrent copy number alterations in hepatocellular carcinoma and putative oncogenes in recurrent gains on 1q. Int J Cancer 123: 2808-2815.
26. Franzen B, Linder S, Uryn K, Alaiya AA, Hirano T, et al. (1996) Expression of tropomyosin isoforms in benign and malignant human breast lesions. Br J Cancer 73: 909-913.
27. Wang FL, Wang Y, Wong WK, Liu Y, Addivinola FJ, et al. (1996) Two differentially expressed genes in normal human prostate tissue and in carcinoma. Cancer Res 56: 3634-3637.
28. Jung MH, Kim SC, Jeon GA, Kim SH, Kim Y, et al. (2000) Identification of differentially expressed genes in normal and tumor human gastric tissue. Genomics 69: 281-286.
29. Alaiya AA, Franzen B, Fujioka K, Moberger B, Schedvins K, et al. (1997) Phenotypic analysis of ovarian carcinoma: polypeptide expression in benign, borderline and malignant tumors. Int J Caner 73: 678-683.
30. Pawlak G, McGarvey TW, Nguyen TB, Tomaszewski JE, Puthiyaveettil R, et al. (2004) Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder. Int J Cancer 110: 368-373.
31. Laing NG, Wilton SD, Akkari PA, Dorosz S, Boundy K, et al. (1995) A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy. Nat Genet 9: 75-79.
32. Penisson-Besnier I, Monnier N, Toutain A, Dubas F, Laing N, (2007) A second pedigree with autosomal dominant nemaline myopathy caused by TPM3 mutation: a clinical and pathological study. Neuromuscul Disord 17: 330-337.
33. Lehtokari VL, Pelin K, Donner K, Voit T, Rudnik-Schoneborn S, et al. (2008) Identification of a founder mutation in TPM3 in nemaline myopathy patients of Turkish origin. Eur J Hum Genet 16: 1055-1061.
34. Clarke NF, Kolski H, Dye DE, Lim E, Smith RLL, et al. (2008) Mutations in TPM3 are a common cause of congenital fiber type disproportion. Ann Neurol 63: 329-337.
35. Lamant L, Dastugue N, Pulford K, Delsol G, Mariame B, (1999) A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation. Blood 93: 3088-3095.
36. Armstrong F, Duplantier MM, Trempat P, Hieblot C, Lamant L, et al. (2004) Differential effects of X-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells. Oncogene 23: 6071-6082.
37. Choi HS, Yim SH, Xu HD, Jung SH, Shin SH, et al. (2010) Tropomyosin3 overexpression and a potential link to epithelial-mesenchymal transition in human hepatocellular carcinoma. BMC Cancer 10: 122.