Expressions of osteopontin (OPN), ανβ3 and Pim-1 associated with poor prognosis in non-small cell lung cancer (NSCLC)

Chinese Journal of Cancer Research

Volumn 24, Issue 2, 2012, Pages 103-108

  Jin, Yi ^a   Tong, Da Yue ^b   Tang, Lu Ying ^a   Chen, Jian Ning ^a   Zhou, Jing ^a   Feng, Zhi Ying ^a   Shao, Chun Kui ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

3; Immunohistochemistry; NSCLC; OPN; Pim 1

Indexed keywords

OSTEOPONTIN; PROTEIN KINASE PIM 1; VITRONECTIN RECEPTOR;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PROTEIN EXPRESSION;

EID: 84863637731     PISSN: 10009604     EISSN: 19930631     Source Type: Journal    
DOI: 10.1007/s11670-012-0103-1     Document Type: Article

References (25)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin 2008; 58:71-96. (Pubitemid 351521864)
2. Macrì A, Versaci A, Lupo G, et al. Role of osteopontin in breast cancer patients. Tumori 2009; 95:48-52.
3. Bao LH, Sakaguchi H, Fujimoto J, et al. Osteopontin in metastatic lesions as a prognostic marker in ovarian cancers. J Biomed Sci 2007; 14:373-81. (Pubitemid 46855418)
4. Hood JD, Cheresh DA. Role of integrins in cell invasion and migration. Nat Rev Cancer 2002; 2:91-100. (Pubitemid 37328796)
5. Verbisck NV, Costa ET, Costa FF, et al. ADAM 23 negatively modulates alpha(v)beta(3) integrin activation during metastasis. Cancer Res 2009; 69:5546-52.
6. Bachmann M, Kosan C, Xing PX, et al. The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C. Int J Biochem Cell Biol 2006; 38:430-43. (Pubitemid 41821890)
7. Rami-Porta R, Crowley JJ, Goldstraw P. The revised TNM staging system for lung cancer. Ann Thorac Cardiovasc Surg 2009; 15:4-9.
8. Di Cristofano A, Pesce B, Cordon-Cardo C, et al. Pten is essential for embryonic development and tumour suppression. Nat Genet 1998; 19:348-55. (Pubitemid 28357906)
9. Senger DR, Wirth DF, Hynes RO. Transformed mammalian cells secrete specific proteins and phosphoproteins. Cell 1979; 16:885-93. (Pubitemid 9161338)
10. Zhang J, Takahashi K, Takahashi F, et al. Differential osteopontin expression in lung cancer. Cancer Lett 2001; 171:215-22. (Pubitemid 32772809)
11. Hu Z, Lin D, Yuan J, et al. Overexpression of osteopontin is associated with more aggressive phenotypes in human non-small cell lung cancer. Clin Cancer Res 2005; 11:4646-52. (Pubitemid 41557181)
12. Rodrigues LR, Teixeira JA, Schmitt FL, et al. The role of osteopontin in tumor progression and metastasis in breast cancer. Cancer Epidemiol Biomarkers Prev 2007; 16:1087-97. (Pubitemid 46984943)
13. Chetty C, Lakka SS, Bhoopathi P, et al. MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells. Int J Cancer 2010; 127:1081-95.
14. Krishnan N, Pan H, Buckley DJ, et al. Prolactin-regulated pim-1 transcription: identification of critical promoter elements and Akt signaling. Endocrine 2003; 20:123-30.
15. Beer AJ, Niemeyer M, Carlsen J, et al. Patterns of alphavbeta3 expression in primary and metastatic human breast cancer as shown by 18F-Galacto-RGD PET. J Nucl Med 2008; 49:255-9. (Pubitemid 351225664)
16. Lössner D, Abou-Ajram C, Benge A, et al. Integrin alphavbeta3 upregulatesintegrin-linked kinase expression in human ovarian cancer cells via enhancement of ILK gene transcription. J Cell Physiol 2009; 220:367-75.
17. Hsu AR, Hou LC, Veeravagu A, et al. In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in an orthotopic glioblastoma model. Mol Imaging Biol 2006; 8:315-23. (Pubitemid 44741368)
18. Wang Z, Bhattacharya N, Weaver M, et al. Pim-1: a serine/ threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis. J Vet Sci 2001; 2:167-79.
19. Guo S, Mao X, Chen J, et al. Overexpression of Pim-1 in bladder cancer. J Exp Clin Cancer Res 2010; 29:161.
20. Warnecke-Eberz U, Bollschweiler E, Drebber U, et al. Prognostic impact of protein overexpression of the proto-oncogene PIM-1 in gastric cancer. Anticancer Res 2009; 29:4451-5.
21. Kim DS, Sung JS, Shin ES, et al. Association of single nucleotide polymorphisms in PIM-1 gene with the risk of Korean lung cancer. Cancer Res Treat 2008; 40:190-6.
22. Zhang Y, Wang Z, Magnuson NS. Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells. Mol Cancer Res 2007; 5:909-22. (Pubitemid 47416668)
23. He HC, Bi XC, Zheng ZW, et al. Real-time quantitative RT-PCR assessment of PIM-1 and hK2 mRNA expression in benign prostate hyperplasia and prostate cancer. Med Oncol 2009; 26:303-8.
24. Fong YC, Liu SC, Huang CY, et al. Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway. Lung Cancer 2009; 64:263-70.
25. Cui R, Takahashi F, Ohashi R, et al. Abrogation of the interaction between osteopontin and alphavbeta3 integrin reduces tumor growth of human lung cancer cells in mice. Lung Cancer 2007; 57:302-10. (Pubitemid 47285419)