Role of vascular endothelial growth factor (VEGF) and VEGF-R genotyping in guiding the metastatic process in pT4a resected gastric cancer patients

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Scartozzi, Mario ^a   Loretelli, Cristian ^a   Galizia, Eva ^b   Mandolesi, Alessandra ^a   Pistelli, Mirco ^a   Bittoni, Alessandro ^a   Giampieri, Riccardo ^a   Faloppi, Luca ^a   Bianconi, Maristella ^a   Del Prete, Michelal ^a   Bianchi, Francesca ^a   Belvederesi, Laura ^a   Bearzi, Italo ^a   Cascinu, Stefano ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b Ospedale Profili   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN P; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CANCER PATIENT; CANCER RECURRENCE; CANCER SURGERY; CARCINOMATOUS PERITONITIS; CORRELATION ANALYSIS; ENZYME ACTIVITY; FEMALE; GENOTYPE; HIGH RISK PATIENT; HISTOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METASTASIS; MULTIVARIATE ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH CANCER;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; FEMALE; GENE EXPRESSION; GENOTYPING TECHNIQUES; HEMATOLOGIC NEOPLASMS; HUMANS; INTEGRIN ALPHA CHAINS; MALE; MIDDLE AGED; PERITONEAL NEOPLASMS; PROTEIN ISOFORMS; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RECURRENCE; STOMACH NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84863624431     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038192     Document Type: Article

References (35)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, et al. (2006) Cancer Statistics 2006. CA Cancer J Clin 56: 106-130.
2. Dicken BJ, Bigam DL Cass C MackeyJR, Joy AA, et al. (2005) Gastric adenocarcinoma. Review and considerations for future directions. Ann Surg. 241: 27-39.
3. Paoletti X, Oba K, Burzykowski T Michiels S, Ohashi Y, et al. (2010) Benefit of adjuvant chemotherapy for resectable gastric cancer: a meta-analysis. JAMA 303: 1729-37.
4. Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, et al. (2001) Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 345: 725-30.
5. Glehen O, Mohamed F, Gilly F, (2004) Peritoneal carcinomatosis from digestive tract cancer: new management by cytoreductive surgery and intraperitoneal chemohyperthermia. Lancet Oncology 5: 219-28.
6. Yan TD, Black D, Sugarbaker PH, Zhu J, Yonemura Y, et al. (2007) A systematic review and meta-analysis of the randomized controlled trials on adjuvant intraperitoneal chemotherapy for resectable gastric cancer. Ann Surg Oncol 14: 2702-2713.
7. Bozzetti F, Baratti D, Kusamura S, Deraco M, (2008) Locoregional treatment of peritoneal carcinomatosis from gastric cancer. J Surg Oncol 98: 273-276.
8. Fujiwara Y, Doki Y, Taniguchi H, Sohma I, Takiguchi S, et al. (2007) Genetic detection of free cancer cells in the peritoneal cavity of the patient with gastric cancer: present status and future perspectives. Gastric Cancer 10: 197-204.
9. Bando E, Yonemura Y, Takeshita Y, Taniguchi K, Yasui T, et al. (1999) intraperitoneal lavage for cytological examination in 1297 patients with gastric carcinoma. Am J Surg 178: 256-62.
10. Scartozzi M, Loretelli C, Bearzi I, Mandolesi A, Galizia E, et al. (2011) Allele polymorphisms of tumor integrins correlate with peritoneal carcinosis capability of gastric cancer cells in radically resected patients. Ann Oncol 22: 897-902.
11. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, et al. (2000) Vascular specific growth factors and blood vessel formation. Nature 407: 242-248.
12. Carmeliet P, Jain RK, (2000) Angiogenesis in cancer and other disease. Nature 407: 249-257.
13. Takahashi Y, Clearly KR, Mai M, Kitadai Y, Bucana CD, et al. (1996) Significance of vessel count and vascular endothelial growth factor and its receptor (KDR) in intestinal type gastric cancer. Clin Cancer Res 2: 1679-1684.
14. Yamamoto S, Yasui W, Kitadai Y, Yokozaki H, Haruma K, et al. (1998) Expression of vascular endothelial growth factors in human gastric carcinomas. Pathology International 48: 499-506.
15. Kitadai Y, (2010) Angiogenesis and Lymphangiogenesis of gastric cancer. J Oncol 10: 468725 Epub 2010 Mar 29.
16. Hansen TF, Sorensen FB, Spindler KL, Olsen DA, Andersen RF, et al. (2010) Microvessel density and the association with single nucleotide polymorphisms of the vascular endothelial growth factor receptor 2 in patients with colorectal cancer. Virchows Arch 456: 251-60.
17. Hansen TF, Garm Spindler KL, Andersen RF, et al. (2011) The predictive value of genetic variations in the vascular endothelial growth factor gene A in metastatic colorectal cancer. The Pharmacogenomics Journal. 11: 53-60.
18. Kaipainen A, Korhonen J, Mustonen T, van Hinsbergh VW, Fang GH, et al. (1995) Expression of the fms-like tyrosine kinese 4 gene becomes restricted to lymphatic endothelium during development. Proc Natl Acad Sci U S A 92: 3566-3570.
19. Skobe M, Hawinghorst T, Jackson DG, Prevo R, Janes L, et al. (2001) Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nature Medicine 7: 192-198.
20. Ceelen WP, Bracke ME, (2009) Peritoneal minimal residual disease in colorectal cancer: mechanism, prevention and treatment. Lancet Oncol 10: 72-9.
21. Kodama M, Kitadai Y, Tanaka M, Kuwai T, Tanaka S, et al. (2008) Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms. Clinical Cancer Res 14: 7205-7214.
22. Chen MH, Tzeng CH, Chen PM, Lin JK, Lin TC, et al. (2011) VEGF-406T polymorphism and its association with VEGF expression and outcome to FOLFOX-4 treatment in patients with colorectal carcinoma. Pharmacogenomics J 11: 227-36.
23. Formento JL, Etienne-Grimaldi MC, Francoual M, Pagès G, Onesto C, et al. (2009) Influence of the VEGF-A 936C>T germinal polymorphism on tumoral VEGF expression in head and neck cancer. Pharmacogenomics 10: 1277-83.
24. Huang JL, Gao PS, Mathias RA, Yao TC, Chen LC, et al. (2004) Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability. Hum Mol Genet 13: 2691-2697.
25. Carter AM, Sachchithananthan M, Stasinopoulos S, et al. (2002) Prothrombin G20210A is a bifunctional gene polymorphism. Thromb Haemost. 87: 846-853.
26. Gehring NH, Frede U, Neu-Yilik G, Neu-Yilik G, Hundsdoerfer P, et al. (2001) Increased efficiency of mRNA 3# end formation: a new genetic mechanism contributing to hereditary thrombophilia. Nat Genet 28: 389-392.
27. Ueda H, Howson JM, Esposito L, Heward J, Snook H, et al. (2003) Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423: 506-511.
28. Day DA, Tuite MF, (1998) Post-transcriptional gene regulatory mechanisms in eukaryotes: an overview. J Endocrinol 157: 361-371.
29. Esketh J, (2004) 3′-Untranslated regions are important in mRNA localization and translation: lessons from selenium and metallothionein. Biochem Soc Trans 32: 990-3.
30. Krippl P, Langsenlehner U, Renner W, Köppel H, Samonigg H, (2003) A common 936 C/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer. Int J Cancer 106: 468-471.
31. Kim JG, Sohn SK, Chae YS, Kang BW, Moon JH, (2007) Vascular endothelial growth factor gene polymorphisms associated with prognosis for patients with gastric cancer. Ann Oncol 18: 1030-1036.
32. Hood J, Cheresh D, (2002) Role of integrins in cell invasion and migration. Nat Rev 2: 91-103.
33. Zhao R, Liu X, Wu X, Liu YF, Zhang ZY, et al. (2010) Vascular endothelial growth factor (VEGF) gastric carcinoma invasiveness via integrin alpha (v) beta6. Cancer Lett 287: 150-156.
34. Smyth SS, Patterson C, (2002) Tiny dancers: the integrin-growth factor nexus in angiogenic signalling. J Cell Biol 158: 17-21.
35. Senger DR, Claffey KB, Benes JE, Perruzzi CA, Sergiou AP, et al. (1997) Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins. Proc Natl Acad Sci U S A 94: 13612-13617.