Pancreatic cancer cells enhance the ability of collagen internalization during epithelial-mesenchymal transition

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Ikenaga, Naoki ^a,b   Ohuchida, Kenoki ^a   Mizumoto, Kazuhiro ^a,c   Akagawa, Shin ^a   Fujiwara, Kenji ^a   Eguchi, Daiki ^a   Kozono, Shingo ^a   Ohtsuka, Takao ^a   Takahata, Shunichi ^a   Tanaka, Masao ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; COLLAGEN RECEPTOR; ENDO180 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; PANCREAS CANCER; PROTEIN EXPRESSION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

CADHERINS; CELL LINE, TUMOR; CELL MOVEMENT; COLLAGEN; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION; HUMANS; INTEGRIN ALPHA2BETA1; PANCREATIC NEOPLASMS; PANCREATIC STELLATE CELLS; PHENOTYPE; PROTEIN TRANSPORT; RECEPTORS, MITOGEN; TRANSFORMING GROWTH FACTOR BETA1; VIMENTIN;

EID: 84863622815     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040434     Document Type: Article

References (39)

1. Vincent A, Herman J, Schulick R, Hruban RH, Goggins M, (2011) Pancreatic cancer. Lancet 378: 607-620.
2. Armstrong T, Packham G, Murphy LB, Bateman AC, Conti JA, et al. (2004) Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma. Clin Cancer Res 10: 7427-7437.
3. Mahadevan D, Von Hoff DD, (2007) Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther 6: 1186-1197.
4. Apte MV, Park S, Phillips PA, Santucci N, Goldstein D, et al. (2004) Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas 29: 179-187.
5. Erkan M, Adler G, Apte MV, Bachem MG, Buchholz M, et al. (2012) StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut 61: 172-178.
6. Friedl P, Alexander S, (2011) Cancer invasion and the microenvironment: plasticity and reciprocity. Cell 147: 992-1009.
7. Arora PD, Manolson MF, Downey GP, Sodek J, McCulloch CA, (2000) A novel model system for characterization of phagosomal maturation, acidification, and intracellular collagen degradation in fibroblasts. J Biol Chem 275: 35432-35441.
8. Engelholm LH, List K, Netzel-Arnett S, Cukierman E, Mitola DJ, et al. (2003) uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. J Cell Biol 160: 1009-1015.
9. Nykvist P, Tu H, Ivaska J, Kapyla J, Pihlajaniemi T, et al. (2000) Distinct recognition of collagen subtypes by alpha(1)beta(1) and alpha(2)beta(1) integrins. Alpha(1)beta(1) mediates cell adhesion to type XIII collagen. J Biol Chem 275: 8255-8261.
10. Wienke D, MacFadyen JR, Isacke CM, (2003) Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. Mol Biol Cell 14: 3592-3604.
11. Mohamed MM, Sloane BF, (2006) Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 6: 764-775.
12. East L, Isacke CM, (2002) The mannose receptor family. Biochim Biophys Acta 1572: 364-386.
13. Huijbers IJ, Iravani M, Popov S, Robertson D, Al-Sarraj S, et al. (2010) A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion. PLoS One 5: e9808.
14. Wienke D, Davies GC, Johnson DA, Sturge J, Lambros MB, et al. (2007) The collagen receptor Endo180 (CD280) Is expressed on basal-like breast tumor cells and promotes tumor growth in vivo. Cancer Res 67: 10230-10240.
15. Thiery JP, Acloque H, Huang RY, Nieto MA, (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.
16. Jamieson NB, Carter CR, McKay CJ, Oien KA, (2011) Tissue biomarkers for prognosis in pancreatic ductal adenocarcinoma: a systematic review and meta-analysis. Clin Cancer Res 17: 3316-3331.
17. Ikenaga N, Ohuchida K, Mizumoto K, Cui L, Kayashima T, et al. (2011) CD10+ pancreatic stellate cells enhance the progression of pancreatic cancer. Gastroenterology 139: 1041-1051, 1051 e1041-1048.
18. Hwang RF, Moore T, Arumugam T, Ramachandran V, Amos KD, et al. (2008) Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res 68: 918-926.
19. Kikuta K, Masamune A, Watanabe T, Ariga H, Itoh H, et al. (2010) Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells. Biochem Biophys Res Commun 403: 380-384.
20. Nelson AR, Fingleton B, Rothenberg ML, Matrisian LM, (2000) Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol 18: 1135-1149.
21. Deryugina EI, Quigley JP, (2006) Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25: 9-34.
22. Coussens LM, Fingleton B, Matrisian LM, (2002) Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 295: 2387-2392.
23. Decock J, Thirkettle S, Wagstaff L, Edwards DR, (2011) Matrix metalloproteinases: protective roles in cancer. J Cell Mol Med 15: 1254-1265.
24. Sameni M, Dosescu J, Moin K, Sloane BF, (2003) Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis. Mol Imaging 2: 159-175.
25. Szpaderska AM, Silberman S, Ahmed Y, Frankfater A, (2004) Sp1 regulates cathepsin B transcription and invasiveness in murine B16 melanoma cells. Anticancer Res 24: 3887-3891.
26. Sloane BF, Yan S, Podgorski I, Linebaugh BE, Cher ML, et al. (2005) Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment. Semin Cancer Biol 15: 149-157.
27. Quintanilla-Dieck MJ, Codriansky K, Keady M, Bhawan J, Runger TM, (2008) Cathepsin K in melanoma invasion. J Invest Dermatol 128: 2281-2288.
28. Niedergethmann M, Wostbrock B, Sturm JW, Willeke F, Post S, et al. (2004) Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma. Pancreas 29: 204-211.
29. Thiery JP, (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454.
30. Kalluri R, Weinberg RA, (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428.
31. Prall F, (2007) Tumour budding in colorectal carcinoma. Histopathology 50: 151-162.
32. Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM,et al. EMT and Dissemination Precede Pancreatic Tumor Formation. Cell 148: 349-361.
33. Segal G, Lee W, Arora PD, McKee M, Downey G, et al. (2001) Involvement of actin filaments and integrins in the binding step in collagen phagocytosis by human fibroblasts. J Cell Sci 114: 119-129.
34. Menke A, Philippi C, Vogelmann R, Seidel B, Lutz MP, et al. (2001) Down-regulation of E-cadherin gene expression by collagen type I and type III in pancreatic cancer cell lines. Cancer research 61: 3508-3517.
35. Curino AC, Engelholm LH, Yamada SS, Holmbeck K, Lund LR, et al. (2005) Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy. J Cell Biol 169: 977-985.
36. Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, et al. (1998) Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 115: 421-432.
37. Bachem MG, Schunemann M, Ramadani M, Siech M, Beger H, et al. (2005) Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology 128: 907-921.
38. Ohuchida K, Mizumoto K, Murakami M, Qian LW, Sato N, et al. (2004) Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions. Cancer Res 64: 3215-3222.
39. Ohuchida K, Mizumoto K, Ishikawa N, Fujii K, Konomi H, et al. (2005) The role of S100A6 in pancreatic cancer development and its clinical implication as a diagnostic marker and therapeutic target. Clin Cancer Res 11: 7785-7793.