Orthosteric and allosteric drug binding sites in the Caenorhabditis elegans mgl-2 metabotropic glutamate receptor

Neuropharmacology

Volumn 63, Issue 4, 2012, Pages 667-674

  Tharmalingam, Sujeenthar ^a   Burns, Andrew R ^b   Roy, Peter J ^b   Hampson, David R ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Allosteric modulator; Calcium sensing receptor; Family C; MPEP; Pharmacophore; Phylogenetic; Venus flytrap

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3 CYANO N (1,3 DIPHENYL 1H PYRAZOL 5 YL)BENZAMIDE; BENZAMIDE DERIVATIVE; FENOBAM; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; PROTEIN MGL 2; QUISQUALIC ACID; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CAENORHABDITIS ELEGANS; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; EMBRYO; HUMAN; HUMAN CELL; PHYLOGENY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; RECEPTOR BINDING; STRUCTURAL HOMOLOGY;

ANIMALS; BENZAMIDES; BINDING SITES; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CALCIUM SIGNALING; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; GTP-BINDING PROTEINS; HEK293 CELLS; HUMANS; KINETICS; LIGANDS; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; PYRAZOLES; QUISQUALIC ACID; RECEPTORS, METABOTROPIC GLUTAMATE; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84863615307     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.05.029     Document Type: Article

References (35)

1. F.C. Acher, C. Selvam, J.P. Pin, C. Goudet, and H.O. Bertrand A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design Neuropharmacology 60 2011 102 107
2. H.O. Bertrand, A.S. Bessis, J.P. Pin, and F.C. Acher Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity J. Med. Chem. 45 2002 3171 3183 (Pubitemid 34774269)
3. Y. Chen, Y. Nong, C. Goudet, K. Hemstapat, P.T. de, and J.P. Pin Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses Mol. Pharmacol. 71 2007 1389 1398 (Pubitemid 46661543)
4. A.D. Conigrave, and D.R. Hampson Broad-spectrum amino acid-sensing class C G-protein coupled receptors: molecular mechanisms, physiological significance and options for drug development Pharmacol. Ther. 127 2010 252 260
5. J. Dillon, N.A. Hopper, L. Holden-Dye, and V. O'Connor Molecular characterization of the metabotropic glutamate receptor family in Caenorhabditis elegans Biochem. Soc. Trans. 34 2006 942 948 (Pubitemid 44796456)
6. E. Doumazane, P. Scholler, J.M. Zwier, T. Eric, P. Rondard, and J.P. Pin A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors FASEB J. 25 2011 66 77
7. L. Gama, S. Wilt, and G. Breitwieser Heterodimerization of calcium sensing receptor with metabotropic glutamate receptor in neurons J. Biol. Chem. 276 2001 39053 39059
8. K.J. Gregory, E.N. Dong, J. Meiler, and P.J. Conn Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential Neuropharmacology 60 2011 66 81
9. D.R. Hampson, E.M. Rose, and J.E. Antflick The structure of metabotropic glutamate receptors The Glutamate Receptors 2008 Human Press
10. H. Jingami, S. Nakanishi, and K. Morikawa Structure of the metabotropic glutamate receptor Curr. Opin. Neurobiol. 13 2003 271 278 (Pubitemid 36792238)
11. G.G. Kinney, J.A. O'Brien, W. Lemaire, M. Burno, D.J. Bickel, and M.K. Clements A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models J. Pharmacol. Exp. Ther. 313 2005 199 206 (Pubitemid 40411343)
12. D. Kuang, Y. Yao, M. Wang, N. Pattabiraman, L.P. Kotra, and D.R. Hampson Molecular similarities in the ligand binding pockets of an odorant receptor and the metabotropic glutamate receptors J. Biol. Chem. 278 2003 42551 42559 (Pubitemid 37310528)
13. D. Kuang, Y. Yao, J. Lam, R.G. Tsushima, and D.R. Hampson Cloning and characterization of a family C orphan G-protein coupled receptor J. Neurochem. 93 2005 383 391 (Pubitemid 40547495)
14. D. Kuang, Y. Yao, D. Maclean, M. Wang, D.R. Hampson, and B.S. Chang Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors Proc. Natl. Acad. Sci. U.S.A. 103 2006 14050 14055 (Pubitemid 44452978)
15. N. Kunishima, Y. Shimada, Y. Tsuji, T. Sato, M. Yamamoto, and T. Kumasaka Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor Nature 407 2000 971 977
16. M.C. Lagerstrom, and H.B. Schioth Structural diversity of G protein-coupled receptors and significance for drug discovery Nat. Rev. Drug Discov. 7 2008 339 357
17. P. Luu, F. Acher, H.O. Bertrand, J. Fan, and J. Ngai Molecular determinants of ligand selectivity in a vertebrate odorant receptor J. Neurosci. 24 2004 10128 10137 (Pubitemid 39492038)
18. M. Maj, V. Bruno, Z. Dragic, R. Yamamoto, G. Battaglia, and W. Inderbitzin (-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection Neuropharmacology 45 2003 895 906 (Pubitemid 37297915)
19. D. Maurel, L. Comps-Agrar, C. Brock, M.L. Rives, E. Bourrier, and M.A. Ayoub Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization Nat. Methods 5 2008 561 567 (Pubitemid 351761765)
20. C. Mitri, M.L. Parmentier, J.P. Pin, J. Bockaert, and Y. Grau Divergent evolution in metabotropic glutamate receptors. A new receptor activated by an endogenous ligand different from glutamate in insects J. Biol. Chem. 279 2004 9313 9320 (Pubitemid 38295995)
21. C.M. Niswender, and P.J. Conn Metabotropic glutamate receptors: physiology, pharmacology, and disease Annu. Rev. Pharmacol. Toxicol. 50 2010 295 322
22. P.J. O'Hara, P.O. Sheppard, H. Thogersen, D. Venezia, B.A. Haldeman, and V. McGrane The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins Neuron 11 1993 41 52 (Pubitemid 23222532)
23. B. Ouattara, L. Gregoire, M. Morissette, F. Gasparini, I. Vranesic, and G. Bilbe Metabotropic glutamate receptor type 5 in levodopa-induced motor complications Neurobiol. Aging 32 2011 1286 1295
24. L.K. Pacey, S. Tharmalingam, and D.R. Hampson Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome J. Pharmacol. Exp. Ther. 338 2011 897 905
25. M.L. Parmentier, J.P. Pin, J. Bockaert, and Y. Grau Cloning and functional expression of a Drosophila metabotropic glutamate receptor expressed in the embryonic CNS J. Neurosci. 16 1996 6687 6694 (Pubitemid 26359352)
26. M.L. Parmentier, T. Galvez, F. Acher, B. Peyre, R. Pellicciari, and Y. Grau Conservation of the ligand recognition site of metabotropic glutamate receptors during evolution Neuropharmacology 39 2000 1119 1131 (Pubitemid 30173177)
27. S.T. Patil, L. Zhang, F. Martenyi, S.L. Lowe, K.A. Jackson, and B.V. Andreev Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial Nat. Med. 13 2007 1102 1107 (Pubitemid 47517511)
28. S. Perovic, A. Krasko, I. Prokic, I.M. Muller, and W.E. Muller Origin of neuronal-like receptors in Metazoa: cloning of a metabotropic glutamate/GABA-like receptor from the marine sponge Geodia cydonium Cell Tissue Res. 296 1999 395 404 (Pubitemid 29219189)
29. M. Pi, P. Faber, G. Ekema, P.D. Jackson, A. Ting, and N. Wang Identification of a novel extracellular cation-sensing G-protein-coupled receptor J. Biol. Chem. 280 2005 40201 40209 (Pubitemid 41779157)
30. J.P. Pin, and R. Duvoisin The metabotropic glutamate receptors: structure and functions Neuropharmacology 34 1995 1 26
31. A.L. Rodriguez, M.D. Grier, C.K. Jones, E.J. Herman, A.S. Kane, and R.L. Smith Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity Mol. Pharmacol. 78 2010 1105 1123
32. D.J. Speca, D.M. Lin, P.W. Sorensen, E.Y. Isacoff, J. Ngai, and A.H. Dittman Functional identification of a goldfish odorant receptor Neuron 23 1999 487 498 (Pubitemid 29359920)
33. D. Tsuchiya, N. Kunishima, N. Kamiya, H. Jingami, and K. Morikawa Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+ Proc. Natl. Acad. Sci. U.S.A. 99 2002 2660 2665 (Pubitemid 34240517)
34. P. Wellendorph, and H. Brauner-Osborne Molecular basis for amino acid sensing by family C G-protein-coupled receptors Br. J. Pharmacol. 156 2009 869 884
35. P. Wellendorph, K.B. Hansen, A. Balsgaard, J.R. Greenwood, J. Egebjerg, and H. Brauner-Osborne Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids Mol. Pharmacol. 67 2005 589 597 (Pubitemid 40365305)