IL-15 expression on RA synovial fibroblasts promotes B cell survival

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Benito Miguel, Marta ^a   García Carmona, Yolanda ^a   Balsa, Alejandro ^a   Bautista Caro, María Belén ^a   Arroyo Villa, Irene ^a   Cobo Ibáñez, Tatiana ^a   Bonilla Hernán, María Gema ^a   de Ayala, Carlos Pérez ^a   Sánchez Mateos, Paloma ^b   Martín Mola, Emilio ^a   Miranda Carús, María Eugenia ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL ACTIVATING FACTOR; INTERLEUKIN 15; MESSENGER RNA; NEUTRALIZING ANTIBODY; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; B LYMPHOCYTE; CELL ISOLATION; CELL SURVIVAL; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; MALE; MEMORY CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RHEUMATOID ARTHRITIS; SURVIVAL RATE; SYNOVIUM; UPREGULATION;

AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID; B-CELL ACTIVATING FACTOR; B-LYMPHOCYTES; CELL SURVIVAL; COCULTURE TECHNIQUES; FEMALE; FIBROBLASTS; HUMANS; IMMUNOLOGIC MEMORY; INTERLEUKIN-15; MALE; MIDDLE AGED; RECEPTORS, INTERLEUKIN-15; SYNOVIAL MEMBRANE; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84863614602     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040620     Document Type: Article

References (42)

1. Zvaifler NJ, Boyle D, Firestein GS, (1994) Early synovitis-synoviocytes and mononuclear cells. Semin Arthritis Rheum 23(6: 11-16.
2. Weyand CM, Kang YM, Kurtin PJ, Goronzy JJ, (2003) The power of the third dimension: tissue architecture and autoimmunity in rheumatoid arthritis. Curr Opin Rheumatol 15: 259-266.
3. Cantaert T, Kolln J, Timmer T, van der Pouw Kraan TC, Vandooren B, et al. (2008) B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis. J Immunol 181: 785-794.
4. Zvaifler NJ, (1974) Rheumatoid synovitis. An extravascular immune complex disease. Arthritis Rheum 17: 297-305.
5. Dörner T, Burmester GR, (2003) The role of B cells in rheumatoid arthritis: mechanisms and therapeutic targets. Curr Opin Rheumatol 15: 246-252.
6. Edwards JC, Leigh RD, Cambridge G, (1997) Expression of molecules involved in B lymphocyte survival and differentiation by synovial fibroblasts. Clin Exp Immunol 108: 407-14.
7. Lindhout E, van Eijk M, van Pel M, Lindeman J, Dinant HJ, et al. (1999) Fibroblast-like synoviocytes from rheumatoid arthritis patients have intrinsic properties of follicular dendritic cells. J Immunol 162: 5949-5956.
8. Reparon-Schuijt CC, van Esch WJ, van Kooten C, Rozier BC, Levarht EW, et al. (2000) Regulation of synovial B cell survival in rheumatoid arthritis by vascular cell adhesion molecule 1 (CD106) expressed on fibroblast-like synoviocytes. Arthritis Rheum 43: 1115-1121.
9. Hayashida K, Shimaoka Y, Ochi T, Lipsky PE, (2000) Rheumatoid arthritis synovial stromal cells inhibit apoptosis and up-regulate Bcl-xL expression by B cells in a CD49/CD29-CD106-dependent mechanism. J Immunol 164: 1110-1116.
10. Burger JA, Zvaifler NJ, Tsukada N, Firestein GS, Kipps TJ, (2001) Fibroblast-like synoviocytes support B-cell pseudoemperipolesis via a stromal cell-derived factor-1- and CD106 (VCAM-1)-dependent mechanism. J Clin Invest 107: 305-315.
11. Ohata J, Zvaifler NJ, Nishio M, Boyle DL, Kalled SL, et al. (2005) Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J Immunol 174: 864-870.
12. Alsaleh G, François A, Knapp AM, Schickel JN, Sibilia J, et al. (2011) Synovial fibroblasts promote immunoglobulin class switching by a mechanism involving BAFF. Eur J Immunol 41: 2113-2122.
13. Rochas C, Hillion S, Saraux A, Mageed RA, Youinou P, et al. (2009) Transmembrane BAFF from rheumatoid synoviocytes requires interleukin-6 to induce the expression of recombination-activating gene in B lymphocytes. Arthritis Rheum 60: 1261-1271.
14. Ernestam S, af Klint E, Catrina AI, Sundberg E, Engström M, et al. (2006) Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor. Arthritis Res Ther 8: R18.
15. Raza K, Falciani F, Curnow SJ, Ross EJ, Lee CY, et al. (2005) Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res Ther 7: R784-795.
16. Miranda-Carús ME, Balsa A, Benito-Miguel M, Pérez de Ayala C, Martín-Mola E, (2004) IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate. J Immunol 173: 1463-1476.
17. Benito-Miguel M, García-Carmona Y, Balsa A, Pérez de Ayala C, Cobo-Ibáñez T, et al. (2009) A dual action of rheumatoid arthritis synovial fibroblast IL-15 expression on the equilibrium between CD4+CD25+ regulatory T cells and CD4+CD25- responder T cells. J Immunol 183: 8268-8279.
18. McInnes IB, Liew FY, (1998) Interleukin 15: a proinflammatory role in rheumatoid arthritis synovitis. Immunol Today 19: 75-79.
19. Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, et al. (1994) Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 264 (5161): 965-968.
20. Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein K, et al. (1994) Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J 13: 2822-2830.
21. Armitage RJ, Macduff BM, Eisenman J, Paxton R, Grabstein KH, (1995) IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol 154: 483-490.
22. Park CS, Yoon SO, Armitage RJ, Choi YS, (2004) Follicular dendritic cells produce IL-15 that enhances germinal center B cell proliferation in membrane-bound form. J Immunol 173: 6676-6683.
23. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, et al. (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31: 315-324.
24. Prevoo ML, van 't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, et al. (1995) Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 38: 44-48.
25. Balsa A, Carmona L, González-Alvaro I, Belmonte MA, Tena X, et al. (2004) Value of Disease Activity Score 28 (DAS28) and DAS28-3 compared to American College of Rheumatology-defined remission in rheumatoid arthritis. J Rheumatol 31: 40-46.
26. Saalbach A, Haustein UF, Anderegg U, (2000) A ligand of human thy-1 is localized on polymorphonuclear leukocytes and monocytes and mediates the binding to activated thy-1-positive microvascular endothelial cells and fibroblasts. J Invest Dermatol 115: 882-888.
27. Kim YS, Maslinski W, Zheng XX, Stevens AC, Li XC, et al. (1998) Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayed-type hypersensitivity. J Immunol 160: 5742-5748.
28. Burton JD, Bamford RN, Peters C, Grant AJ, Kurys G, et al. (1994) A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci U S A 91: 4935-4939.
29. Waldmann TA, (2006) The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat Rev Immunol 6: 595-601.
30. Fehniger TA, Caligiuri MA, (2001) Interleukin 15: biology and relevance to human disease. Blood 97: 14-32.
31. Dubois S, Mariner J, Waldmann TA, Tagaya Y, (2002) IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity 17: 537-547.
32. Kurowska M, Rudnicka W, Kontny E, Janicka I, Chorazy M, et al. (2002) Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex: endogenous IL-15 in autocrine fashion enhances cell proliferation and expression of Bcl-x(L) and Bcl-2. J Immunol 169: 1760-1767.
33. Briard D, Brouty-Boyé D, Azzarone B, Jasmin C, (2002) Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15. J Immunol 168: 4326-4332.
34. Wenxin L, Jinxiang F, Yong W, Wenxiang L, Wenbiao S, et al. (2005) Expression of membrane-bound IL-15 by bone marrow fibroblast-like stromal cells in aplastic anemia. Int Immunol 17: 429-4237.
35. Carrasco YR, Batista FD, (2006) B-cell activation by membrane-bound antigens is facilitated by the interaction of VLA-4 with VCAM-1. EMBO J 25: 889-899.
36. Hase H, Kanno Y, Kojima M, Hasegawa K, Sakurai D, et al. (2004) BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex. Blood 103: 2257-2265.
37. Chomarat P, Briolay J, Banchereau J, Miossec P, (1993) Increased production of soluble CD23 in rheumatoid arthritis, and its regulation by interleukin-4. Arthritis Rheum 36: 234-242.
38. Prokopec KE, Rhodiner M, Matt P, Lindqvist U, Kleinau S, (2010) Down regulation of Fc and complement receptors on B cells in rheumatoid arthritis. Clin Immunol 137: 322-329.
39. Catalán D, Aravena O, Sabugo F, Wurmann P, Soto L, et al. (2010) B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgammaRIIb, which are modulated by anti-tumor necrosis factor therapy. Arthritis Res Ther 12: R68.
40. Butcher EC, Picker LJ, (1996) Lymphocyte homing and homeostasis. Science 272 (5258): 60-66.
41. Höpken UE, Winter S, Achtman AH, Krüger K, Lipp M, (2010) CCR7 regulates lymphocyte egress and recirculation through body cavities. J Leukoc Biol 87: 671-682.
42. Buckley CD, (2003) Michael Mason prize essay 2003. Why do leucocytes accumulate within chronically inflamed joints? Rheumatology (Oxford) 42: 1433-1444.