Modeling multicomponent adsorption of monoclonal antibody charge variants in cation exchange columns

AIChE Journal

Volumn 58, Issue 8, 2012, Pages 2503-2511

  Tao, Yinying ^a,c   Chen, Nianyun ^a,d   Carta, Giorgio ^a   Ferreira, Gisela ^b   Robbins, David ^b  

^a University of Virginia   (United States)

^b MEDIMMUNE   (United States)

^c BIOGEN   (United States)

^d SHIRE   (United States)

Author keywords

Diffusion; Ion exchange; Mass transfer modeling; Monoclonal antibody charge variants; Multicomponent adsorption kinetics

Indexed keywords

ADSORPTION KINETICS; AGAROSE; CATION EXCHANGES; CO-ADSORPTION; DEXTRAN POLYMERS; DIFFUSION MODEL; FRONTAL ANALYSIS; LONG RESIDENCE TIME; MACRO PORES; MACROPOROUS; MASS TRANSFER MODELING; MAXWELL-STEFAN MODELS; MULTICOMPONENT ADSORPTION; PORE DIFFUSIVITY; PROTEIN ADSORPTION KINETICS; RESIDENCE TIME; SEQUENTIAL ADSORPTION; SINGLE FILE DIFFUSION; TRANSPORT MODELS;

DIFFUSION; ION EXCHANGE; KINETICS; MONOCLONAL ANTIBODIES; POSITIVE IONS;

ADSORPTION;

EID: 84863599867     PISSN: 00011541     EISSN: 15475905     Source Type: Journal    
DOI: 10.1002/aic.13718     Document Type: Article

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