Nanostructured PEG-based hydrogels with tunable physical properties for gene delivery to human mesenchymal stem cells

Biomaterials

Volumn 33, Issue 27, 2012, Pages 6533-6541

  Li, Yan ^a,b   Yang, Chuan ^a   Khan, Majad ^a   Liu, Shaoqiong ^a   Hedrick, James L ^c   Yang, Yi Yan ^a   Ee, Pui Lai R ^b  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c IBM ALMADEN RESEARCH CENTER   (United States)

Author keywords

Gene delivery; Human mesenchymal stem cells; Micelles; PEG hydrogels

Indexed keywords

AMPHIPHILICS; CELL BEHAVIORS; CELL MATRIX INTERACTIONS; CELL VIABILITY; CELLULAR BEHAVIORS; CROSS-LINKING DEGREE; END-GROUPS; FIELD EMISSION SCANNING ELECTRON MICROSCOPES; GENE DELIVERY; GENE EXPRESSION LEVELS; GENE TRANSFECTION; HUMAN MESENCHYMAL STEM CELLS; HYDROGEL NETWORKS; IN-SITU; INTERNAL MORPHOLOGY; MICHAEL ADDITIONS; MICROENVIRONMENTS; MTT ASSAYS; NANO-SIZED; NANO-STRUCTURED; NANOSTRUCTURED HYDROGELS; PEG HYDROGEL; PHYSIOLOGICAL CONDITION; SELF-ASSEMBLED; THREE DIMENSIONAL SCAFFOLD;

ADDITION REACTIONS; BEHAVIORAL RESEARCH; BIOMECHANICS; BLOCK COPOLYMERS; CELL PROLIFERATION; CROSSLINKING; CYTOLOGY; DRUG THERAPY; GENE EXPRESSION; GENE TRANSFER; MECHANICAL PROPERTIES; MICELLES; MOLECULAR BIOLOGY; OPTIMIZATION; PHYSICAL PROPERTIES; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SCAFFOLDS (BIOLOGY); STEM CELLS; THREE DIMENSIONAL;

HYDROGELS;

COPOLYMER; MACROGOL; NANOMATERIAL; POLYCARBONATE;

ARTICLE; CELL ADHESION; CELL INTERACTION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MECHANICS; MESENCHYMAL STEM CELL; MICELLE; MICHAEL ADDITION; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

CELL DEATH; CELL SURVIVAL; DNA; ELASTIC MODULUS; GENE TRANSFER TECHNIQUES; HUMANS; HYDROGELS; LUCIFERASES; MAGNETIC RESONANCE SPECTROSCOPY; MESENCHYMAL STEM CELLS; MICELLES; NANOSTRUCTURES; PHYSICAL PHENOMENA; POLYCARBOXYLATE CEMENT; POLYETHYLENE GLYCOLS; SULFONES; SURFACE-ACTIVE AGENTS; TRANSFECTION;

EID: 84863583384     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.05.043     Document Type: Article

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