Association of an NFKB1 intron SNP (rs4648068) with gastric cancer patients in the Han Chinese population

BMC Gastroenterology

Volumn 12, Issue , 2012, Pages

  Lu, Renquan ^a,b   Gao, Xiang ^a   Chen, Yin ^a   Ni, Jian ^c   Yu, Yongfu ^b   Li, Sheng ^d,e   Guo, Lin ^a,b  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b FUDAN UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

^d DALIAN MEDICAL UNIVERSITY   (China)

^e Yulong Biomedical Group   (China)

Author keywords

Gastric cancer; Nfkb1; Single nucleotide polymorphism (snp); Susceptibility

Indexed keywords

ADULT; ARTICLE; CANCER STAGING; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INTRON; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; NFKB1 GENE; RISK ASSESSMENT; SEROSA; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH CANCER; TUMOR DIFFERENTIATION;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHINA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMOZYGOTE; HUMANS; INTRONS; MALE; MIDDLE AGED; NF-KAPPA B P50 SUBUNIT; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; STOMACH NEOPLASMS; SURVIVAL RATE;

EID: 84863577513     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-12-87     Document Type: Article

References (37)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011, 61:69-90. 10.3322/caac.20107, 21296855.
2. Chen CD, Sawyers CL. NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer. Mol Cell Biol 2002, 22:2862-2870. 10.1128/MCB.22.8.2862-2870.2002, 133743, 11909978.
3. Tai DI, Tsai SL, Chang YH, Huang SN, Chen TC, Chang KS, Liaw YF. Constitutive activation of nuclear factor kappaB in hepatocellular carcinoma. Cancer 2000, 89:2274-2281. 10.1002/1097-0142(20001201)89:11<2274::AID-CNCR16>3.0.CO;2-2, 11147598.
4. Biswas DK, Dai SC, Cruz A, Weiser B, Graner E, Pardee AB. The nuclear factor kappa B (NF-kappa B): a potential therapeutic target for estrogen receptor negative breast cancers. Proc Natl Acad Sci U S A 2001, 98:10386-10391. 10.1073/pnas.151257998, 56970, 11517301.
5. Lind DS, Hochwald SN, Malaty J, Rekkas S, Hebig P, Mishra G, Moldawer LL, Copeland EM, Mackay S. Nuclear factor-kappa B is upregulated in colorectal cancer. Surgery 2001, 130:363-369. 10.1067/msy.2001.116672, 11490372.
6. Wang W, Abbruzzese JL, Evans DB, Chiao PJ. Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. Oncogene 1999, 18:4554-4563. 10.1038/sj.onc.1202833, 10467400.
7. Rueda B, Nunez C, Lopez-Nevot MA, Paz Ruiz M, Urcelay E, De la Concha EG, Martin J. Functional polymorphism of the NFKB1 gene promoter is not relevant in predisposition to celiac disease. Scand J Gastroenterol 2006, 41:420-423. 10.1080/00365520500325929, 16635909.
8. Uranishi H, Tetsuka T, Yamashita M, Asamitsu K, Shimizu M, Itoh M, Okamoto T. Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator. J Biol Chem 2001, 276:13395-13401. 10.1074/jbc.M011176200, 11278855.
9. Kim JG, Sohn SK, Chae YS, Moon JH, Kim SN, Kang BW, Kim GC, Lee MH, Jeon SW, Chung HY, Yu W. No association of the NFKB1 insertion/deletion promoter polymorphism with survival in patients with gastric cancer. Jpn J Clin Oncol 2009, 39:497-501. 10.1093/jjco/hyp056, 19509001.
10. Lo SS, Chen JH, Wu CW, Lui WY. Functional polymorphism of NFKB1 promoter may correlate to the susceptibility of gastric cancer in aged patients. Surgery 2009, 145:280-285. 10.1016/j.surg.2008.11.001, 19231580.
11. Tchernitsa O, Kasajima A, Schafer R, Kuban RJ, Ungethum U, Gyorffy B, Neumann U, Simon E, Weichert W, Ebert MP, Rocken C. Systematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression. J Pathol 2010, 222:310-319. 10.1002/path.2759, 20726036.
12. Inagaki Y, Tang W, Xu HL, Guo Q, Mafune K, Konishi T, Nakata M, Sugawara Y, Kokudo N. Localization of N-myc downstream-regulated gene 1 in gastric cancer tissue. Dig Liver Dis 2009, 41:96-103. 10.1016/j.dld.2008.04.003, 18602353.
13. Akiyama Y, Watkins N, Suzuki H, Jair KW, van Engeland M, Esteller M, Sakai H, Ren CY, Yuasa Y, Herman JG, Baylin SB. GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol 2003, 23:8429-8439. 10.1128/MCB.23.23.8429-8439.2003, 262684, 14612389.
14. Wang S, Tian L, Zeng Z, Zhang M, Wu K, Chen M, Fan D, Hu P, Sung JJ, Yu J. IkappaBalpha polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese. BMC Gastroenterol 2010, 10:15. 10.1186/1471-230X-10-15, 2829487, 20132559.
15. Ju H, Lim B, Kim M, Kim YS, Kim WH, Ihm C, Noh SM, Han DS, Yu HJ, Choi BY, Kang C. A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression. Neoplasia 2009, 11:1340-1347. 2794515, 20019842.
16. Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA. Selecting a maximally informative set of singlenucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 2004, 74:106-120. 10.1086/381000, 1181897, 14681826.
17. Sjakste T, Paramonova N, Grislis Z, Trapina I, Kairisa D. Analysis of the single-nucleotide polymorphism in the 5'UTR and part of intron I of the sheep MSTN gene. DNA Cell Biol 2011, 30:433-444. 10.1089/dna.2010.1153, 21323579.
18. Zhu LB, Xu Q, Hong CY, Yue Z, Zhang Y, Ye HN, Yuan Y. XPC gene intron 11 C/A polymorphism is a predictive biomarker for the sensitivity to NP chemotherapy in patients with non-small cell lung cancer. Anticancer Drugs 2010, 21:669-673.
19. Chen P, Xie LJ, Huang GY, Zhao XQ, Chang C. Mutations of connexin43 in fetuses with congenital heart malformations. Chin Med J (Engl) 2005, 118:971-976.
20. Zhang X, Fu L, Zhang Q, Yan L, Ma Y, Tu B, Liu N, Qiao J. Association of TRB3 Q84R polymorphism with polycystic ovary syndrome in Chinese women. Reprod Biol Endocrinol 2011, 9:46. 10.1186/1477-7827-9-46, 3094280, 21492415.
21. Elens L, Bouamar R, Hesselink DA, Haufroid V, van der Heiden IP, van Gelder T, van Schaik RH. A New Functional CYP3A4 Intron 6 Polymorphism Significantly Affects Tacrolimus Pharmacokinetics in Kidney Transplant Recipients. Clin Chem 2011, 57:1574-1583. 10.1373/clinchem.2011.165613, 21903774.
22. Chuo LJ, Wu ST, Chang HI, Kuo YM. Extremely rare incidence of the UBQLN1 polymorphism (UBQ-8i) in Taiwan Chinese with Alzheimer's disease. Neurosci Lett 2010, 475:108-109. 10.1016/j.neulet.2010.03.061, 20350585.
23. Athanasiu L, Mattingsdal M, Melle I, Inderhaug E, Lien T, Agartz I, Lorentzen S, Morken G, Andreassen OA, Djurovic S. Intron 12 in NTRK3 is associated with bipolar disorder. Psychiatry Res 2011, 185:358-362. 10.1016/j.psychres.2010.05.011, 20554328.
24. Weickert CS, Miranda-Angulo AL, Wong J, Perlman WR, Ward SE, Radhakrishna V, Straub RE, Weinberger DR, Kleinman JE. Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia. Hum Mol Genet 2008, 17:2293-2309. 10.1093/hmg/ddn130, 2465798, 18424448.
25. Silecchia G, Greco F, Bacci V, Boru C, Pecchia A, Casella G, Rizzello M, Basso N. Results after laparoscopic adjustable gastric banding in patients over 55 years of age. Obes Surg 2005, 15:351-356. 10.1381/0960892053576622, 15826468.
26. Christie J, Shepherd NA, Codling BW, Valori RM. Gastric cancer below the age of 55: implications for screening patients with uncomplicated dyspepsia. Gut 1997, 41:513-517. 10.1136/gut.41.4.513, 1891526, 9391251.
27. Arendt R, Hauzeui F. Relations between age, gastric juice secretion and gastritis. Z Alternsforsch 1973, 27:161-167.
28. Billington BP. Gastric ulcer: age, sex, and a curious retrogression. Australas Ann Med 1960, 9:111-121.
29. Aggarwal BB. Nuclear factor-kappaB: the enemy within. Cancer Cell 2004, 6:203-208. 10.1016/j.ccr.2004.09.003, 15380510.
30. Sen R, Baltimore D. Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell 1986, 47:921-928. 10.1016/0092-8674(86)90807-X, 3096580.
31. Liu-Mares W, Sun Z, Bamlet WR, Atkinson EJ, Fridley BL, Slager SL, de Andrade M, Goode EL. Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules. BMC Proc 2007, 1(Suppl 1):S126. 10.1186/1753-6561-1-s1-s126, 2367504, 18466468.
32. Kraja AT, Culverhouse R, Daw EW, Wu J, Van Brunt A, Province MA, Borecki IB. The Genetic Analysis Workshop 16 Problem 3: simulation of heritable longitudinal cardiovascular phenotypes based on actual genome-wide single-nucleotide polymorphisms in the Framingham Heart Study. BMC Proc 2009, 3(Suppl 7):S4. 10.1186/1753-6561-3-s7-s4, 2795938, 20018031.
33. Lewander A, Butchi AK, Gao J, He LJ, Lindblom A, Arbman G, Carstensen J, Zhang ZY, Sun XF. Polymorphism in the promoter region of the NFKB1 gene increases the risk of sporadic colorectal cancer in Swedish but not in Chinese populations. Scand J Gastroenterol 2007, 42:1332-1338. 10.1080/00365520701396026, 17852842.
34. Gao L, Nieters A, Brenner H. Meta-analysis: tumour invasion-related genetic polymorphisms and gastric cancer susceptibility. Aliment Pharmacol Ther 2008, 28:565-573. 10.1111/j.1365-2036.2008.03760.x, 18544073.
35. Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G. Inflammation and cancer: how hot is the link?. Biochem Pharmacol 2006, 72:1605-1621. 10.1016/j.bcp.2006.06.029, 16889756.
36. Yang J, Pan WH, Clawson GA, Richmond A. Systemic targeting inhibitor of kappaB kinase inhibits melanoma tumor growth. Cancer Res 2007, 67:3127-3134. 10.1158/0008-5472.CAN-06-3547, 2665271, 17409419.
37. Huang S, Robinson JB, Deguzman A, Bucana CD, Fidler IJ. Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res 2000, 60:5334-5339.