Functional polymorphism of the NFKB1 gene promoter is not relevant in predisposition to celiac disease

Scandinavian Journal of Gastroenterology

Volumn 41, Issue 4, 2006, Pages 420-423

  Rueda, Blanca ^a   Núñez, Concepción ^b   López Nevot, Miguel Á ^c   Ruiz, Ma Paz ^a   Urcelay, Elena ^b   De La Concha, Emilio G ^b   Martín, Javier ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^c HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

Author keywords

Celiac disease; NFKB1 gene; Polymorphism; Transmission disequilibrium test

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ARTICLE; AUTOIMMUNITY; CASE CONTROL STUDY; CELIAC DISEASE; CHILD; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; FLUORESCENCE; GENE DELETION; GENE INSERTION; GENETIC PREDISPOSITION; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; NFKB1 GENE; PRIORITY JOURNAL; PROMOTER REGION;

ALLELES; CELIAC DISEASE; CHILD; DISEASE SUSCEPTIBILITY; FEMALE; GENOTYPE; HUMANS; MALE; NF-KAPPA B P50 SUBUNIT; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS);

EID: 33646406823     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520500325929     Document Type: Article

References (24)

1. Green PH, Jabri B. Coeliac disease. Lancet 2003;362(9381):383-91.
2. Hadjivassiliou M, Williamson CA, Woodroofe N. The immunology of gluten sensitivity: beyond the gut. Trends Immunol 2004;25:578-82.
3. Sollid LM. Coeliac disease: dissecting a complex inflammatory disorder. Nature Rev Immunol 2002;2:647.
4. Chen LF, Greene WC. Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol 2004;5:392-401.
5. Maiuri MC, De Stefano D, Mele G, Fecarotta S, Greco L, Troncone R, et al. Nuclear factor kappa B is activated in small intestinal mucosa of celiac patients. J Mol Med 2003;81:373-9.
6. Jelinkova L, Tuckova L, Cinova J, Flegelova Z, Tlaskalova-Hogenova H. Gliadin stimulates human monocytes to production of IL-8 and TNF-alpha through a mechanism involving NF-kappaB. FEBS Lett 2004;571:81-5.
7. Maiuri MC, De Stefano D, Mele G, Iovine B, Bevilacqua MA, Greco L, et al. Gliadin increases iNOS gene expression in interferon-gamma-stimulated RAW 264.7 cells through a mechanism involving NF-kappa B. Naunyn Schmiedebergs Arch Pharmacol 2003;368:63-71.
8. Xie QW, Kashiwabara Y, Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem 1994;269:4705-8.
9. Yamamoto K, Arakawa T, Ueda N, Yamamoto S. Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem 1995;270:31315-20.
10. Karban AS, Okazaki T, Panhuysen CI, Gallegos T, Potter JJ, Bailey-Wilson JE, et al. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet 2004;13:35-45.
11. Revised criteria for diagnosis of coeliac disease. Report of Working Group of the European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child 1990;65:909-11.
12. Dudbridge F. Methods and software for association tests of uncertain haplotypes in case-parent trios. Am J Hum Genet 2002;71 Suppl:A2338.
13. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 2003;25:115-21.
14. Gauderman WJ. Sample size requirements for association studies of gene-gene interaction. Am J Epidemiol 2002;155:478-84.
15. Louka AS, Sollid LM. HLA in coeliac disease: unravelling the complex genetics of a complex disorder. Tissue Antigens 2003;61:105-17.
16. Sollid LM. Molecular basis of celiac disease. Annu Rev Immunol 2000;18:53.
17. Popat S, Bevan S, Braegger CP, Busch A, O'Donoghue D, Falth-Magnusson K, et al. Genome screening of coeliac disease. J Med Genet 2002;39:328-31.
18. Haimila K, Smedberg T, Mustalahti K, Maki M, Partanen J, Holopainen P. Genetic association of coeliac disease susceptibility to polymorphisms in the ICOS gene on chromosome 2q33. Genes Immun 2004;5:85-92.
19. Rueda B, Martínez A, López-Nevot MA, Mas-Fontao A, Paco L, Ortega E, et al. A functional variant of IFN gamma gene is associated with coeliac disease. Genes Immun 2004;5:517-9.
20. Orange JS, Levy O, Geha RS. Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation. Immunol Rev 2005;203:21-37.
21. Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, et al. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat Genet 2004;36:837-41.
22. Orozco G, Sanchez E, Collado MD, López-Nevot MA, Paco L, Garcia A, et al. Analysis of the functional NFKB1 promoter polymorphism in rheumatoid arthritis and systemic lupus erythematosus. Tissue Antigens 2005;65:183-6.
23. Oliver JG-GM, Paco L, López-Nevot MA, Piñero A, Correro F, Martin L, et al. A functional polymorphism of the NFKB1 promoter is not associated with ulcerative colitis in a Spanish population. Inflamm Bowel Dis 2005;11:576-9.
24. Rueda B, López-Nevot MA, Ruiz MP, Ortega E, Maldonado J, Lopez M, et al. CA microsatellite polymorphism of the nuclear factor kappa B1 gene in celiac disease. Eur J Immunogenet 2004;31:129-32.