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Volumn 7, Issue 2, 2012, Pages 100-104

Evaluation of clinical efficacy of fasudil for the treatment of pulmonary arterial hypertension

Author keywords

Endothelium; Fasudil; Pulmonary arterial hypertension; Rho kinase

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; FASUDIL; FLUOXETINE; PLACEBO; RHO KINASE; SEROTONIN;

EID: 84863551553     PISSN: 15748901     EISSN: None     Source Type: Journal    
DOI: 10.2174/157489012801227238     Document Type: Article
Times cited : (29)

References (34)
  • 1
    • 44349172995 scopus 로고    scopus 로고
    • Current status of bosentan for treatment of pulmonary hypertension
    • Raja SG, Dreyfus GD. Current status of bosentan for treatment of pulmonary hypertension. Ann Card Anaesth 2008; 11: 6-14.
    • (2008) Ann Card Anaesth , vol.11 , pp. 6-14
    • Raja, S.G.1    Dreyfus, G.D.2
  • 2
    • 79953686516 scopus 로고    scopus 로고
    • New perspectives for the treatment of pulmonary hypertension
    • Baliga RS, MacAllister RJ, Hobbs AJ. New perspectives for the treatment of pulmonary hypertension. Br J Pharmacol 2011; 163: 125-40.
    • (2011) Br J Pharmacol , vol.163 , pp. 125-140
    • Baliga, R.S.1    Macallister, R.J.2    Hobbs, A.J.3
  • 3
  • 4
    • 77955512464 scopus 로고    scopus 로고
    • Rhokinase inhibition: A novel therapeutic target for the treatment of cardiovascular diseases
    • Dong M, Yan BP, Liao JK, Lam YY, Yip GW, Yu CM. Rhokinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases. Drug Discov Today 2010; 15: 622-9.
    • (2010) Drug Discov Today , vol.15 , pp. 622-629
    • Dong, M.1    Yan, B.P.2    Liao, J.K.3    Lam, Y.Y.4    Yip, G.W.5    Yu, C.M.6
  • 5
    • 70350724182 scopus 로고    scopus 로고
    • RhoA/Rho-kinase signaling: A therapeutic target in pulmonary hypertension
    • Barman SA, Zhu S, White RE. RhoA/Rho-kinase signaling: a therapeutic target in pulmonary hypertension. Vasc Health Risk Manag 2009; 5: 663-71.
    • (2009) Vasc Health Risk Manag , vol.5 , pp. 663-671
    • Barman, S.A.1    Zhu, S.2    White, R.E.3
  • 6
    • 34247168120 scopus 로고    scopus 로고
    • Recent progress in the treatment of pulmonary arterial hypertension: Expectation for rhokinase inhibitors
    • Fukumoto Y, Tawara S, Shimokawa H. Recent progress in the treatment of pulmonary arterial hypertension: Expectation for rhokinase inhibitors. Tohoku J Exp Med 2007; 211: 309-20.
    • (2007) Tohoku J Exp Med , vol.211 , pp. 309-320
    • Fukumoto, Y.1    Tawara, S.2    Shimokawa, H.3
  • 8
    • 69549129206 scopus 로고    scopus 로고
    • Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension
    • Do e Z, Fukumoto Y, Takaki A, Tawara S, Ohashi J, Nakano M, et al. Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension. Circ J 2009; 73: 1731-9.
    • (2009) Circ J , vol.73 , pp. 1731-1739
    • Do e, Z.1    Fukumoto, Y.2    Takaki, A.3    Tawara, S.4    Ohashi, J.5    Nakano, M.6
  • 10
    • 28444461454 scopus 로고    scopus 로고
    • Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension
    • Guilluy C, Sauzeau V, Rolli-Derkinderen M, Guerin P, Sagan C, Pacaud P, et al. Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension. Br J Pharmacol 2005; 146: 1010-18.
    • (2005) Br J Pharmacol , vol.146 , pp. 1010-1018
    • Guilluy, C.1    Sauzeau, V.2    Rolli-Derkinderen, M.3    Guerin, P.4    Sagan, C.5    Pacaud, P.6
  • 11
    • 22744455284 scopus 로고    scopus 로고
    • Inhibition of Rho-kinase attenuates hypoxiainduced angiogenesis in the pulmonary circulation
    • Hyvelin JM, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P. Inhibition of Rho-kinase attenuates hypoxiainduced angiogenesis in the pulmonary circulation. Circ Res 2005; 97: 185-91.
    • (2005) Circ Res , vol.97 , pp. 185-191
    • Hyvelin, J.M.1    Howell, K.2    Nichol, A.3    Costello, C.M.4    Preston, R.J.5    McLoughlin, P.6
  • 13
    • 49049100968 scopus 로고    scopus 로고
    • Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone
    • Homma N, Nagaoka T, Karoor V, Imamura M, Taraseviciene-Stewart L, Walker LA, et al. Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone. Am J Physiol Lung Cell Mol Physiol 2008; 295: L71-8.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295
    • Homma, N.1    Nagaoka, T.2    Karoor, V.3    Imamura, M.4    Taraseviciene-Stewart, L.5    Walker, L.A.6
  • 14
    • 34147189502 scopus 로고    scopus 로고
    • Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats
    • Oka M, Homma N, Taraseviciene-Stewart L, Morris KG, Kraskauskas D, Burns N, et al. Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats. Circ Res 2007; 100: 923-9.
    • (2007) Circ Res , vol.100 , pp. 923-929
    • Oka, M.1    Homma, N.2    Taraseviciene-Stewart, L.3    Morris, K.G.4    Kraskauskas, D.5    Burns, N.6
  • 15
    • 33645816773 scopus 로고    scopus 로고
    • Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat
    • Nagaoka T, Gebb SA, Karoor V, Homma N, Morris KG, McMurtry IF, et al. Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat. J Appl Physiol 2006; 100: 996-1002.
    • (2006) J Appl Physiol , vol.100 , pp. 996-1002
    • Nagaoka, T.1    Gebb, S.A.2    Karoor, V.3    Homma, N.4    Morris, K.G.5    McMurtry, I.F.6
  • 16
    • 42049083338 scopus 로고    scopus 로고
    • Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries
    • Broughton BR, Walker BR, Resta TC. Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 2008; 294: L797-806.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.294
    • Broughton, B.R.1    Walker, B.R.2    Resta, T.C.3
  • 17
    • 33646763902 scopus 로고    scopus 로고
    • Rho kinases in cardiovascular physiology and pathophysiology
    • Loirand G, Guerin P, Pacaud P. Rho kinases in cardiovascular physiology and pathophysiology. Circ Res 2006; 98: 322-34.
    • (2006) Circ Res , vol.98 , pp. 322-334
    • Loirand, G.1    Guerin, P.2    Pacaud, P.3
  • 18
    • 0036182417 scopus 로고    scopus 로고
    • Antianginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: A multicenter study
    • Shimokawa H, Hiramori K, Iinuma H, Hosoda S, Kishida H, Osada H, et al. Antianginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study. J Cardiovasc Pharmacol 2002; 39: 319-27.
    • (2002) J Cardiovasc Pharmacol , vol.39 , pp. 319-327
    • Shimokawa, H.1    Hiramori, K.2    Iinuma, H.3    Hosoda, S.4    Kishida, H.5    Osada, H.6
  • 19
    • 0032877847 scopus 로고    scopus 로고
    • Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm
    • Shimokawa H, Seto M, Katsumata N, Amano M, Kozai T, Yamawaki T, et al. Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc Res 1999; 43: 1029-39.
    • (1999) Cardiovasc Res , vol.43 , pp. 1029-1039
    • Shimokawa, H.1    Seto, M.2    Katsumata, N.3    Amano, M.4    Kozai, T.5    Yamawaki, T.6
  • 20
    • 0031469111 scopus 로고    scopus 로고
    • Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta
    • Katsumata N, Shimokawa H, Seto M, Kozai T, Yamawaki T, Kuwata K, et al. Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta. Circulation 1997; 96: 4357-63.
    • (1997) Circulation , vol.96 , pp. 4357-4363
    • Katsumata, N.1    Shimokawa, H.2    Seto, M.3    Kozai, T.4    Yamawaki, T.5    Kuwata, K.6
  • 21
    • 34249301303 scopus 로고    scopus 로고
    • Development of Rho-kinase inhibitors for cardiovascular medicine
    • Shimokawa H, Rashid M. Development of Rho-kinase inhibitors for cardiovascular medicine. Trends Pharmacol Sci 2007; 28: 296-302.
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 296-302
    • Shimokawa, H.1    Rashid, M.2
  • 25
    • 24144498411 scopus 로고    scopus 로고
    • Rho-kinase is an important therapeutic target in cardiovascular medicine
    • Shimokawa H, Takeshita A. Rho-kinase is an important therapeutic target in cardiovascular medicine. Arterioscler Thromb Vasc Biol 2005; 25: 1767-75.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1767-1775
    • Shimokawa, H.1    Takeshita, A.2
  • 26
    • 53849089211 scopus 로고    scopus 로고
    • McMurtry Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension
    • Oka M, Fagan KA, Jones PL, McMurtry Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension. Br J Pharmacol 2008; 155: 444-54.
    • (2008) Br J Pharmacol , vol.155 , pp. 444-454
    • Oka, M.1    Fagan, K.A.2    Jones, P.L.3
  • 27
    • 4544388803 scopus 로고    scopus 로고
    • Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase
    • Fagan KA, Oka M, Bauer NR, Gebb SA, Ivy DD, Morris KG, et al. Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol 2004; 287: L656-64.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Fagan, K.A.1    Oka, M.2    Bauer, N.R.3    Gebb, S.A.4    Ivy, D.D.5    Morris, K.G.6
  • 28
    • 10744222390 scopus 로고    scopus 로고
    • Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats
    • Abe K, Shimokawa H, Morikawa K, Uwatoku T, Oi K, Matsumoto Y, et al. Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res 2004; 94: 385-93.
    • (2004) Circ Res , vol.94 , pp. 385-393
    • Abe, K.1    Shimokawa, H.2    Morikawa, K.3    Uwatoku, T.4    Oi, K.5    Matsumoto, Y.6
  • 30
    • 14244260105 scopus 로고    scopus 로고
    • Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension
    • Fukumoto Y, Matoba T, Ito A, Tanaka H, Kishi T, Hayashidani S, et al. Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart 2005; 91: 391-2.
    • (2005) Heart , vol.91 , pp. 391-392
    • Fukumoto, Y.1    Matoba, T.2    Ito, A.3    Tanaka, H.4    Kishi, T.5    Hayashidani, S.6
  • 31
    • 31644431508 scopus 로고    scopus 로고
    • Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension
    • Ishikura K, Yamada N, Ito M, Ota S, Nakamura M, Isaka N, et al. Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension. Circ J 2006; 70: 174-8.
    • (2006) Circ J , vol.70 , pp. 174-178
    • Ishikura, K.1    Yamada, N.2    Ito, M.3    Ota, S.4    Nakamura, M.5    Isaka, N.6
  • 32
    • 77950921360 scopus 로고    scopus 로고
    • Acute vasodilator effects of inhaled fasudil, a specific Rhokinase inhibitor, in patients with pulmonary arterial hypertension
    • Fujita H, Fukumoto Y, Saji K, Sugimura K, Demachi J, Nawata J, et al. Acute vasodilator effects of inhaled fasudil, a specific Rhokinase inhibitor, in patients with pulmonary arterial hypertension. Heart Vessels 2010; 25: 144-9.
    • (2010) Heart Vessels , vol.25 , pp. 144-149
    • Fujita, H.1    Fukumoto, Y.2    Saji, K.3    Sugimura, K.4    Demachi, J.5    Nawata, J.6
  • 33
    • 64249097973 scopus 로고    scopus 로고
    • Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease
    • Li F, Xia W, Yuan S, Sun R. Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease. Pediatr Cardiol 2009; 30: 363-6.
    • (2009) Pediatr Cardiol , vol.30 , pp. 363-366
    • Li, F.1    Xia, W.2    Yuan, S.3    Sun, R.4


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