Screening for novel lead compounds increasing insulin expression in medullary thymic epithelial cells

European Journal of Pharmacology

Volumn 688, Issue 1-3, 2012, Pages 84-89

  Yang, Xiu Ying ^a,b   Levi, Dina ^b   Ounissi Benkalha, Houria ^b   Yu, Xiao Yan ^a   Qu, Hui Qi ^b,c   Polychronakos, Constantin ^b   Du, Guan Hua ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^c UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Autoimmune regulator; High throughput screening assay; Immune tolerance; Insulin; Medullary thymic epithelial cell; Type 1 diabetes

Indexed keywords

INSULIN;

ALLELE; ARTICLE; HIGH THROUGHPUT SCREENING; HUMAN; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PLASMID; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; THYMUS; VARIABLE NUMBER OF TANDEM REPEAT;

ANIMALS; CELL LINE; CLONE CELLS; DRUG EVALUATION, PRECLINICAL; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INSULIN; LUCIFERASES; MICE; THYMUS GLAND; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84863514578     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.03.047     Document Type: Article

References (28)

1. J. Abramson, M. Giraud, C. Benoist, and D. Mathis Aire's partners in the molecular control of immunological tolerance Cell 140 2010 123 135
2. S. Anjos, and C. Polychronakos Mechanisms of genetic susceptibility to type I diabetes: beyond HLA Mol. Genet. Metab. 81 2004 187 195
3. I. Bergerot, C. Ploix, J. Petersen, V. Moulin, C. Rask, N. Fabien, M. Lindblad, A. Mayer, C. Czerkinsky, J. Holmgren, and C. Thivolet A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes Proc. Natl. Acad. Sci. U. S. A. 94 1997 4610 4614
4. S. Cernea, and P. Pozzilli New potential treatments for protection of pancreatic B-cell function in type 1 diabetes Diabet. Med. 25 2008 1259 1267
5. A.A. Chentoufi, and C. Polychronakos Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes Diabetes 51 2002 1383 1390
6. R.K. Chin, J.C. Lo, O. Kim, S.E. Blink, P.A. Christiansen, P. Peterson, Y. Wang, C. Ware, and Y.X. Fu Lymphotoxin pathway directs thymic Aire expression Nat. Immunol. 4 2003 1121 1127
7. J. Derbinski, A. Schulte, B. Kyewski, and L. Klein Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self Nat. Immunol. 2 2001 1032 1039
8. J. Derbinski, J. Gabler, B. Brors, S. Tierling, S. Jonnakuty, M. Hergenhahn, L. Peltonen, J. Walter, and B. Kyewski Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels J. Exp. Med. 202 2005 33 45
9. G.S. Eisenbarth, S. Srikanta, R. Jackson, S. Rabinowe, R. Dolinar, T. Aoki, and M.A. Morris Anti-thymocyte globulin and prednisone immunotherapy of recent onset type 1 diabetes mellitus Diabetes Res. 2 1985 271 276
10. B. Faideau, C. Lotton, B. Lucas, I. Tardivel, J.F. Elliott, C. Boitard, and J.C. Carel Tolerance to proinsulin-2 is due to radioresistant thymic cells J. Immunol. 177 2006 53 60
11. Y. Fan, W.A. Rudert, M. Grupillo, J. He, G. Sisino, and M. Trucco Thymus-specific deletion of insulin induces autoimmune diabetes EMBO J. 28 2009 2812 2824
12. E.A. Gale, P.J. Bingley, C.L. Emmett, and T. Collier European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes Lancet 363 2004 925 931
13. V. Geenen, M. Mottet, O. Dardenne, H. Kermani, H. Martens, J.M. Francois, M. Galleni, D. Hober, S. Rahmouni, and M. Moutschen Thymic self-antigens for the design of a negative/tolerogenic self-vaccination against type 1 diabetes Curr. Opin. Pharmacol. 10 2010 461 472
14. K.C. Herold, W. Hagopian, J.A. Auger, E. Poumian-Ruiz, L. Taylor, D. Donaldson, S.E. Gitelman, D.M. Harlan, D. Xu, R.A. Zivin, and J.A. Bluestone Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus N. Engl. J. Med. 346 2002 1692 1698
15. A. Hviid, M. Stellfeld, J. Wohlfahrt, and M. Melbye Childhood vaccination and type 1 diabetes N. Engl. J. Med. 350 2004 1398 1404
16. E. Hypponen, E. Laara, A. Reunanen, M.R. Jarvelin, and S.M. Virtanen Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study Lancet 358 2001 1500 1503
17. D. Levi, and C. Polychronakos Regulation of insulin gene expression by cytokines and cell-cell interactions in mouse medullary thymic epithelial cells Diabetologia 52 2009 2151 2158
18. D. Mathis, and C. Benoist Aire Annu. Rev. Immunol. 27 2009 287 312
19. S. Noso, K. Kataoka, Y. Kawabata, N. Babaya, Y. Hiromine, K. Yamaji, T. Fujisawa, S. Aramata, T. Kudo, S. Takahashi, and H. Ikegami Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes Diabetes 59 2010 2579 2587
20. M.O. Palumbo, D. Levi, A.A. Chentoufi, and C. Polychronakos Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones Diabetes 55 2006 2595 2601
21. N. Petrovsky, D. Silva, and D.A. Schatz Vaccine therapies for the prevention of type 1 diabetes mellitus Paediatr. Drugs 5 2003 575 582
22. A. Pugliese, M. Zeller, A. Fernandez Jr., L.J. Zalcberg, R.J. Bartlett, C. Ricordi, M. Pietropaolo, G.S. Eisenbarth, S.T. Bennett, and D.D. Patel The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes Nat. Genet. 15 1997 293 297
23. N. Shehadeh, F. Calcinaro, B.J. Bradley, I. Bruchim, P. Vardi, and K.J. Lafferty Effect of adjuvant therapy on development of diabetes in mouse and man Lancet 343 1994 706 707
24. J. Silverstein, N. Maclaren, W. Riley, R. Spillar, D. Radjenovic, and S. Johnson Immunosuppression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus N. Engl. J. Med. 319 1988 599 604
25. C.R. Stiller, J. Dupre, M. Gent, M.R. Jenner, P.A. Keown, A. Laupacis, R. Martell, N.W. Rodger, G.B. von, and B.M. Wolfe Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset Science 223 1984 1362 1367
26. P. Vafiadis, S.T. Bennett, J.A. Todd, J. Nadeau, R. Grabs, C.G. Goodyer, S. Wickramasinghe, E. Colle, and C. Polychronakos Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus Nat. Genet. 15 1997 289 292
27. E.S. Venanzi, D.H. Gray, C. Benoist, and D. Mathis Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected J. Immunol. 179 2007 5693 5700
28. M. Yano, N. Kuroda, H. Han, M. Meguro-Horike, Y. Nishikawa, H. Kiyonari, K. Maemura, Y. Yanagawa, K. Obata, S. Takahashi, T. Ikawa, R. Satoh, H. Kawamoto, Y. Mouri, and M. Matsumoto Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance J. Exp. Med. 205 2008 2827 2838