Experimental comparison of high-density scintillators for EMCCD-based gamma ray imaging

Physics in Medicine and Biology

Volumn 57, Issue 14, 2012, Pages 4545-4554

  Heemskerk, Jan W T ^a,b   Kreuger, Rob ^a   Goorden, Marlies C ^a,c   Korevaar, Marc A N ^a,c   Salvador, Samuel ^a   Seeley, Zachary M ^d   Cherepy, Nerine J ^d   Van Der Kolk, Erik ^a   Payne, Stephen A ^d   Dorenbos, Pieter ^a   Beekman, Freek J ^a,c,e  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

^e MILABS   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DECAY TIME; ENERGY RESOLUTIONS; EXPERIMENTAL COMPARISON; FRAME RATE; GAMMA CAMERAS; GAMMA-RAY IMAGING; HIGH SPATIAL RESOLUTION; HIGH-DENSITY; LIGHT YIELD; LOW NOISE; PERFORMANCE COMPARISON; PHOTON-COUNTING GAMMA CAMERAS; POLYCRYSTALLINE CERAMICS; REDUCED ENERGY; SCINTILLATION CAMERAS; SCINTILLATION LIGHT; SCINTILLATOR MATERIALS; SPATIAL RESOLUTION; TRANSPARENT CERAMIC;

CAMERAS; CERAMIC MATERIALS; EUROPIUM; GADOLINIUM; GAMMA RAYS; IMAGE RESOLUTION; IONIZATION; SCINTILLATION COUNTERS;

SCINTILLATION;

DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT;

ARTICLE; COMPARATIVE STUDY; DIAGNOSTIC IMAGING; ELECTRICAL EQUIPMENT; GAMMA CAMERA; GAMMA RADIATION; INSTRUMENTATION; PHOTON; PROBABILITY; SCINTILLATION COUNTING;

DIAGNOSTIC IMAGING; ELECTRICAL EQUIPMENT AND SUPPLIES; GAMMA CAMERAS; GAMMA RAYS; PHOTONS; PROBABILITY; RADIOPHARMACEUTICALS; SCINTILLATION COUNTING;

EID: 84863514033     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/57/14/4545     Document Type: Article

References (33)

1. Barber H B 1999 Applications of semiconductor detectors to nuclear medicine Nucl. Instrum Methods A 436 102-10
2. Beekman F J 2007 Radiation detection apparatus Patent WO 2007/011214 A1
3. Beekman F J and Vastenhouw B 2004 Design and simulation of a high-resolution stationary SPECT system for small animals Phys. Med. Biol. 49 4579-92
4. Berger M J, Hubbell J H, Seltzer S M, Chang J, Coursey J S, Sukumar J, Zucker D S and Olsen K 1998 NIST XCOM: Photon Cross Sections Database, http://www.nist.gov/pml/data/xcom/index.cfm
5. Caballo J, Baily A, Kitchen I, Prydderch M, Clark A, Turchetta R and Wells K 2007 Digital autoradiography using room temperature CCD and CMOS imaging technology Phys. Med. Biol. 52 4993-5011
6. Cherepy N J et al 2011 Performance of europium-doped strontium iodide, transparent ceramics and bismuth-loaded polymer scintillators Proc. SPIE 8142 81420W
7. De Vree G A, Westra A H, Moody I, Van der Have F, Ligtvoet C M and Beekman F J 2005 Photon-counting gamma camera based on an electron-multiplying CCD IEEE Trans. Nucl. Sci. 52 580-88
8. Goorden M C, Rentmeester M C M and Beekman F J 2009 Theoretical analysis of full-ring multi-pinhole brain SPECT Phys. Med. Biol. 54 6593-610
9. Gruner S M, Tate M W and Eikenberry E F 2002 Charge-coupled device area x-ray detectors Rev. Sci. Instrum. 73 2815-42
10. He Z, Li W, Knoll G F, Wehe D K, Berry J and Stahle C M 1999 3-D position sensitive CdZnTe gamma-ray spectrometers Nucl. Instrum. Methods A 422 173-78
11. Heemskerk J W T, Korevaar M A N, Kreuger R, Ligtvoet C M, Schotanus P and Beekman F J 2009 A micro-machined retro-reflector for improving light yield in ultra-high-resolution gamma cameras Phys. Med. Biol. 54 3003-14
12. Heemskerk J W T, Westra A H, Linotte P M, Ligtvoet C M, Zbijewski W and Beekman F J 2007 Front-illuminated versus back-illuminated photon-counting CCD-based gamma camera: important consequences for spatial resolution and energy resolution Phys. Med. Biol. 52 N149-62
13. Karellas A, Liu H, Reinhardt C, Harris L J and Brill A B 1993 Imaging of radionuclide emissions with a low-noise charge-coupled device IEEE Trans. Nucl. Sci. 40 979-82
14. Korevaar M A N, Goorden M C, Heemskerk J W T and Beekman F J 2011 Maximum-likelihood scintillation detection for EM-CCD based gamma cameras Phys. Med. Biol. 56 4785-801
15. Korevaar M A N, Heemskerk J W T, Goorden M C and Beekman F J 2009a Multi-scale algorithm for improved scintillation detection in a CCD based gamma cameras Phys. Med. Biol. 54 831-42
16. Korevaar M A N, Heemskerk J W T and Beekman F J 2009b A pinhole gamma camera with optical depth-of-interaction elimination Phys. Med. Biol. 54 N267-72
17. MacDonald J H, Wells K, Reader A J and Ott R J 1997 A CCD-based tissue imaging system Nucl. Instrum. Methods A A392 220-6
18. Matteson J L et al 1997 CdZnTe arrays for astrophysics applications Proc. SPIE 3115 160-75
19. Meng L J 2006 An intensified EMCCD camera for low energy gamma ray imaging applications IEEE Trans. Nucl. Sci. 53 2376-84
20. Meng L J, Clinthorne N H, Skinner S, Hay R V and Gross M 2006 Design and feasibility study of a single photon emission microscope system for small animal I-125 imaging IEEE Trans. Nucl. Sci. 53 1168-78
21. Miller B W, Bradford B H, Barrett H H, Shestakova I, Singh B and Nagarkar V V 2006 Single-photon spatial and energy resolution enhancement of a columnar CsI(Tl)/EMCCD gamma-camera using maximum-likelihood estimation Proc. SPIE 6142 61421T
22. Nagarkar V V, Shestakova I, Gaysinskiy V, Tipnis S V, Singh B, Barber W, Hasegawa B and Entine G 2006 A CCD-based detector for SPECT IEEE Trans. Nucl. Sci. 53 54-58
23. Peterson T E and Furenlid L R 2011 SPECT detectors: the Anger camera and beyond Phys. Med. Biol. 56 R145-82
24. Phillips W C, Stanton M, Stewart A, Qian H, Ingersoll C and Sweet R M 2000 Multiple CCD detector for macromolecular x-ray crystallography J. Appl. Cryst. 33 243-51
25. Ponchut C, Zontone F and Graafsma H 2005 Experimental comparison of pixel detector arrays and CCD-based systems for x-ray area detection on synchrotron beamlines IEEE Trans. Nucl. Sci. 52 1760-5
26. Rentmeester M C M, Van der Have F and Beekman F J 2007 Optimizing multi-pinhole SPECT geometries using an analytical model Phys. Med. Biol. 52 2567-81
27. Rogulski M M, Barber H B, Barrett H H, Shoemaker R L and Woolfenden J M 1993 Ultra-high resolution brain SPECT imaging - simulation results IEEE Trans. Nucl. Sci. 40 1123-9
28. 3:Eu ceramics by sinter and HIP optimization Opt. Mater. 33 1721-6
29. 3 transparent ceramics Opt. Mater. 31 729-33
30. Suzuki M, Yamamoto M, Kumasaka T, Sato K, Toyokawa H, Aries I F, Jerram P A, Gullick D and Ueki T 1999 A multiple-CCD x-ray detector and its basic characterization J. Synchrotron Radiat. 6 6-18
31. Teo B K, Shestakova I, Sun M, Barber W C, Hasegawa B H and Nagarkar V V 2006 Evaluation of a EMCCD detector for emission-transmission computed tomography IEEE Trans. Nucl. Med. 53 2495-9
32. Van Eijk C W E 2002 Inorganic scintillators in medical imaging Phys. Med. Biol. 47 R85-106
33. Vavrik D, Jakubek J, Visschers J, Pospisil S, Ponchut C and Zemankova J 2002 First tests of a medipix-1 pixel detector for x-ray dynamic defectoscopy Nucl. Instrum. Methods A 487 216-23