Effect of RhoA on transforming growth factor β1-induced rat hepatic stellate cell migration

Liver International

Volumn 32, Issue 7, 2012, Pages 1093-1102

  Li, Lei ^a   Wang, Ji Yao ^a   Yang, Chang Qing ^b   Jiang, Wei ^a  

^a FUDAN UNIVERSITY   (China)

^b TONGJI UNIVERSITY   (China)

Author keywords

Cell migration; Cytoskeleton; Hepatic stellate cell; Liver fibrosis; RhoA; Transforming growth factor 1

Indexed keywords

GLUTATHIONE TRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN CDC42; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMAD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA1;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL MOTILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; LIVER FIBROSIS; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL;

ANIMALS; CELL MOVEMENT; CELLS, CULTURED; CYTOSKELETON; HEPATIC STELLATE CELLS; MALE; MICROSCOPY, CONFOCAL; RATS; RATS, SPRAGUE-DAWLEY; RHOA GTP-BINDING PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84863512094     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2012.02809.x     Document Type: Article

References (33)

1. Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008; 134: 1655-69.
2. Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 2007; 117: 539-48.
3. Brenner DA, Waterboer T, Choi SK, et al. New aspects of hepatic fibrosis. J Hepatol 2000; 32: 32-8.
4. Yang C, Zeisberg M, Mosterman B, et al. Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors. Gastroenterology 2003; 124: 147-59.
5. Wang XM, Yu DM, McCaughan GW, Gorrell MD. Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line. Hepatology 2005; 42: 935-45.
6. Dormann D, Weijer CJ. Imaging of cell migration. EMBO J 2006; 25: 3480-93.
7. Le Clainche C, Carlier MF. Regulation of actin assembly associated with protrusion and adhesion in cell migration. Physiol Rev 2008; 88: 489-513.
8. Lanzetti L. Actin in membrane trafficking. Curr Opin Cell Biol 2007; 19: 453-8.
9. Lemonnier M, Landraud L, Lemichez E. Rho GTPase-activating bacterial toxins: from bacterial virulence regulation to eukaryotic cell biology. FEMS Microbiol Rev 2007; 31: 515-34.
10. Ridley AJ. Rho GTPases and cell migration. J Cell Sci 2001; 114: 2713-22.
11. Moustakas A, Stournaras C. Regulation of actin organisation by TGF-beta in H-ras-transformed fibroblasts. J Cell Sci 1999; 112: 1169-79.
12. Bhowmick NA, Ghiassi M, Bakin A, et al. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 2001; 12: 27-36.
13. Riccalton-Banks L, Bhandari R, Fry J, Shakesheff KM. A simple method for the simultaneous isolation of stellate cells and hepatocytes from rat liver tissue. Mol Cell Biochem 2003; 248: 97-102.
14. Yu L, Hebert MC, Zhang YE. TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses. EMBO J 2002; 21: 3749-59.
15. Matsuzaki K. Modulation of TGF-beta signalling during progression of chronic liver diseases. Front Biosci 2009; 14: 2923-34.
16. Moreira RK. Hepatic stellate cells and liver fibrosis. Arch Pathol Lab Med 2007; 131: 1728-34.
17. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008; 214: 199-210.
18. Papakonstanti EA, Stournaras C. Cell responses regulated by early reorganization of actin cytoskeleton. FEBS Lett 2008; 582: 2120-7.
19. Le Clainche C, Carlier MF. Regulation of actin assembly associated with protrusion and adhesion in cell migration. Physiol Rev 2008; 88: 489-513.
20. Mierke CT. The role of vinculin in the regulation of the mechanical properties of cells. Cell Biochem Biophys 2009; 53: 115-26.
21. Charest PG, Firtel RA. Big roles for small GTPases in the control of directed cell movement. Biochem J 2007; 401: 377-90.
22. Price LS, Collard JG. Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion. Semin Cancer Biol 2001; 11: 167-73.
23. Itoh K, Yoshioka K, Akedo H, et al. An essential part for Rho-associated kinase in the transcellular invasion of tumour cells. Nat Med 1999; 5: 221-5.
24. O'Connor KL, Nguyen BK, Mercurio AM. RhoA function in lamellae formation and migration is regulated by the alpha6beta4 integrin and cAMP metabolism. J Cell Biol 2000; 148: 253-8.
25. Ray RM, Patel A, Viar MJ, et al. RhoA inactivation inhibits cell migration but does not mediate the effects of polyamine depletion. Gastroenterology 2002; 123: 196-205.
26. Stam JC, Michiels F, van der Kammen RA, Moolenaar WH, Collard JG. Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signalling. EMBO J 1998; 17: 4066-74.
27. Banyard J, Anand-Apte B, Symons M, Zetter BR. Motility and invasion are differentially modulated by Rho family GTPases. Oncogene 2000; 19: 580-91.
28. Allen WE, Zicha D, Ridley AJ, Jones GE. A role for Cdc42 in macrophage chemotaxis. J Cell Biol 1998; 141: 1147-57.
29. Tominaga T, Sahai E, Chardin P, et al. Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signalling. Mol Cell 2000; 5: 13-25.
30. Edlund S, Landstrom M, Heldin CH, Aspenstrom P. Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signalling by small GTPases Cdc42 and RhoA. Mol Biol Cell 2002; 13: 902-14.
31. Kawada N, Seki S, Kuroki T, Kaneda K. ROCK inhibitor Y-27632 attenuates stellate cell contraction and portal pressure increase induced by endothelin-1. Biochem Biophys Res Commun 1999; 266: 296-300.
32. Fukushima M, Nakamuta M, Kohjima M, et al. Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells. Liver Int 2005; 25: 829-38.
33. Ikeda H, Kume Y, Tejima K, et al. Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats. Am J Physiol Gastrointest Liver Physiol 2007; 293: 911-7.