Genetic polymorphisms of human β-defensins in patients with ischemic stroke

Acta Neurologica Scandinavica

Volumn 126, Issue 2, 2012, Pages 109-115

  Tiszlavicz, Z ^a   Somogyvari F ^a   Szolnoki, Z ^b   Sztriha, L K ^a   Nemeth B ^a   Vecsei L ^a   Mandi Y ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b Pandy Kalman County Hospital   (Hungary)

Author keywords

Human beta defensin; Ischemic stroke; Polymorphism

Indexed keywords

BETA DEFENSIN 1; BETA DEFENSIN 2; BETA DEFENSIN 4;

ADULT; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; COPY NUMBER VARIATION; FEMALE; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; SINGLE NUCLEOTIDE POLYMORPHISM;

BETA-DEFENSINS; FEMALE; GENE DOSAGE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STROKE;

EID: 84863500907     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2011.01613.x     Document Type: Article

References (38)

1. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nature Rev Immunol 2003;3:710-20.
2. Duirr M, Peschel A. Chemokines meet defensins: the merging concepts of chemoattractants and antimicrobial peptides in host defense. Infect Immun 2002;70:6515-7.
3. Schutte BC, Mitros JP, Bartlett JA et al. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. Proc Nat Acad Sci 2002;9:14611.
4. Boman HG. Antibacterial peptides: basic facts and emerging concepts. J Intern Med 2003;254:197-215.
5. De Smet K, Contreras R. Human antimicrobial peptides: defensins, cathelicidins and histatins. Biotechnol Lett 2005;27:1337-47.
6. Pazgier M, Hoover DM, Yang D et al. Human beta-defensins. Cell Mol Life Sci 2006;63:1294-313.
7. Zhao C, Wang I, Lehrer RI. Widespread expression of hBD-1 in human secretory glands and epithelia. FEBS Lett 1996;396:319-22.
8. Hao H-N, Zhao J, Lotoczky G et al. Induction of human β-defensin-2 expression in human astrocytes by lipopolysaccharide and cytokines. J Neurochem 2001;77:1027-35.
9. Duits LA, Ravensbergen B, Rademaker M et al. Expression of β-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Immunology 2002;106:517-25.
10. Tiszlavicz Z, Endrész V, Németh B et al. Inducible expression of human β-defensin 2 by Chlamydophila pneumoniae in brain capillary endothelial cells. Innate Immun 2011;17:463-9.
11. Kiechl S, Egger G, Mayr M et al. Chronic infections and risk of carotid atherosclerosis: prospective results from a large population study. Circulation 2001;103:1064-70.
12. Gulcher JR, Gretarsdottir S, Helgadottir A et al. Genes contributing to risk for common forms of stroke. Trends Mol Med 2005;11:217-24.
13. Lindsberg PJ, Grau AJ. Inflammation and infections as risk factors for ischemic stroke. Stroke 2003;34:2518-32.
14. Morgan L, Humphries SE. The genetics of stroke. Curr Opin Lipidol 2005;16:193-9.
15. Matarin M, Singleton A, Hardy J et al. The genetics of ischemic stroke. J Intern Med 2009;267:139-55.
16. Elkind MSV, Ramakrishnan P, Moon YP et al. Infectious burden and risk of stroke. Arch Neurol 2010;67:33-8.
17. Heuschmann PU, Neureiter D, Gesslein M et al. Association between infection with Helicobacter pylori and Chlamydia pneumoniae and risk of ischemic stroke subtypes: results from a population-based case-control study. Stroke 2001;32:2253-8.
18. Madre JG, Garcia JL, Gonzales RC et al. Association between seropositivity to Chlamydia pneumoniae and acute ischaemic stroke. Eur J Neurol 2002;9:303-6.
19. Pietroiusti A, Diomedi M, Silvestrini M et al. Cytotoxin-associated gene-A-positive Helicobacter pylori strains are associated with atherosclerotic stroke. Circulation 2002;106:580-4.
20. Mayr M, Kiechl S, Mendall MA et al. Increased risk of atherosclerosis is confined to CagA-positive Helicobacter pylori strains: prospective results from the Bruneck study. Stroke 2003;34:610-5.
21. Elkind MS, Tondella ML, Feikin DR et al. Seropositivity to Chlamydia pneumoniae is associated with risk of first ischemic stroke. Stroke 2006;37:790-5.
22. Kis Z, Sas K, Gyulai Z et al. Chronic infections and genetic factors in the development of ischemic stroke. New Microbiol 2007;30:213-20.
23. Revilla M, Obach V, Cervera A et al. A-174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction. Neurosci Lett 2002;324:29-32.
24. Szilágyi A, Blasko B, Szilassy D et al. Real-time PCR quantification of human complement C4A and C4B genes. BMC Genet 2006;7:1-6.
25. Ito D, Murata M, Tanashi N et al. Polymorphisms and risk of stroke. Stroke 2000;31:2661-4.
26. Humphries SE, Morgan L. Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches. Lancet Neurol 2004;3:227-36.
27. Yamada Y, Ichiara S, Nishida T. Proinflammatory gene polymorphisms and ischemic stroke. Curr Pharm Des 2008;14:3590-600.
28. Dork T, Stuhrmann M. Polymorphisms of the human beta-defensin-1 gene. Mol Cell Probes 1998;12:171-3.
29. Sun CQ, Arnold R, Fernandez-Golarz C et al. Human beta-defensin-1, a potential chromosome 8p tumor suppressor: control of transcription and induction of apoptosis in renal cell carcinoma. Cancer Res 2006;66:8542-9.
30. Levy H, Raby BA, Lake S et al. Association of defensin beta I gene polymorphisms with asthma. J Allergy Clin Immunol 2005;115:252-8.
31. Matsushita I, Hasegawa K, Nakata K et al. Genetic variants of human beta-defensin-I and chronic obstructive pulmonary disease. Biochem Biophys Res Commun 2009;29:17-22.
32. Kocsis ÁK, Lakatos PL, Somogyvári F et al. Association of beta-defensin 1 nucleotide polymorphisms with Crohn's disease. Scand J Gastroenterol 2007;17:1-9.
33. Tesse R, Cardinale F, Santostasi T et al. Association of β-defensin-1 gene polymorphisms with Pseudomonas aeruginosa airway colonization in cystic fibrosis. Genes Immun 2008;9:57-60.
34. Hollox EJ, Armour JA, Barber JC. Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster. Am J Hum Genet 2003;73:591-581.
35. Linzmeier RM, Ganz T. Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in α- and β-defensin regions at 8p22-p23. Genomics 2005;86:423-30.
36. Bandaru VCSS, Laxmi V, Neeraja M et al. J Neurol Sci 2008;272:115-22.
37. Szolnoki Z, Somogyvári F, Kondacs A et al. Evaluation of the interactions of common genetic mutations in stroke subtypes. J Neurol 2002;249:1391-7.
38. Janssens W, Nuytten H, Dupont LJ et al. Genomic copy number determines functional expression of β-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010;182:163-9.