BMP2 differentially regulates the expression of Gremlin1 and Gremlin2, the negative regulators of BMP function, during osteoblast differentiation

Calcified Tissue International

Volumn 91, Issue 1, 2012, Pages 88-96

  Suzuki, Dai ^a   Yamada, Atsushi ^a   Aizawa, Ryo ^a   Funato, Sakie ^a   Matsumoto, Takashi ^a   Suzuki, Wataru ^a   Takami, Masamichi ^a   Miyamoto, Yoichi ^a   Suzawa, Tetsuo ^a   Yamamoto, Matsuo ^a   Baba, Kazuyoshi ^a   Kamijo, Ryutaro ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

Bone morphogenetic protein; Gremlin1; Gremlin2; Osteoblast

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BONE MORPHOGENETIC PROTEIN 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 14; SMAD4 PROTEIN; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SCREENING; GREMLIN1 GENE; GREMLIN2 GENE; MOLECULAR INTERACTION; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; REGULATOR GENE; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION REGULATION; MICE; OSTEOBLASTS; PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD4 PROTEIN;

EID: 84863487749     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-012-9614-5     Document Type: Article

References (23)

1. Urist MR (1965) Bone: formation by autoinduction. Science 150:893-899
2. Urist MR, Kovacs S, Yates KA (1986) Regeneration of an enchondroma defect under the influence of an implant of human bone morphogenetic protein. J Hand Surg Am 11:417-419 (Pubitemid 16121403)
3. Avsian-Kretchmer O, Hsueh AJ (2004) Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists. Mol Endocrinol 18:1-12 (Pubitemid 38073149)
4. Hsu DR, Economides AN, Wang X, Eimon PM, Harland RM (1998) The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell 1:673-683 (Pubitemid 128379245)
5. Minabe-Saegusa C, Saegusa H, Tsukahara M, Noguchi S (1998) Sequence and expression of a novel mouse gene PRDC (protein related to DAN and cerberus) identified by a gene trap approach. Dev Growth Differ 40:343-353 (Pubitemid 28259485)
6. Merino R, Rodriguez-Leon J, Macias D, Ganan Y, Economides AN, Hurle JM (1999) The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb. Development 126:5515-5522 (Pubitemid 30015943)
7. Sudo S, Avsian-Kretchmer O, Wang LS, Hsueh AJ (2004) Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. J Biol Chem 279:23134-23141 (Pubitemid 38685618)
8. Pearce JJ, Penny G, Rossant J (1999) A mouse cerberus/Dan-related gene family. Dev Biol 209:98-110 (Pubitemid 29194316)
9. Charite J, McFadden DG, Olson EN (2000) The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development. Development 127:2461-2470 (Pubitemid 30386583)
10. Nilsson O, Parker EA, Hegde A, Chau M, Barnes KM, Baron J (2007) Gradients in bone morphogenetic protein-related gene expression across the growth plate. J Endocrinol 193:75-84 (Pubitemid 46638534)
11. Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dolle P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A (2011) A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol 9(1):e1000582
12. Ideno H, Takanabe R, Shimada A, Imaizumi K, Araki R, Abe M, Nifuji A (2009) Protein related to DAN and cerberus (PRDC) inhibits osteoblastic differentiation and its suppression promotes osteogenesis in vitro. Exp Cell Res 315:474-484
13. Khokha MK, Hsu D, Brunet LJ, Dionne MS, Harland RM (2003) Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat Genet 34:303-307 (Pubitemid 36792863)
14. Verheyden JM, Sun X (2008) An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth. Nature 454:638-641
15. Benazet JD, Bischofberger M, Tiecke E, Goncalves A, Martin JF, Zuniga A, Naef F, Zeller R (2009) A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning. Science 323:1050-1053
16. Gazzerro E, Smerdel-Ramoya A, Zanotti S, Stadmeyer L, Durant D, Economides AN, Canalis E (2007) Conditional deletion of gremlin causes a transient increase in bone formation and bone mass. J Biol Chem 282:31549-31557 (Pubitemid 350044884)
17. Katagiri T, Yamaguchi A, Komaki M, Abe E, Takahashi N, Ikeda T, Rosen V, Wozney JM, Fujisawa-Sehara A, Suda T (1994) Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol 127:1755-1766 (Pubitemid 24380911)
18. Chen G, Deng C, Li YP (2012) TGF-beta and BMP signaling in osteoblast differentiation and bone formation. Int J Biol Sci 8:272-288
19. Frank NY, Kho AT, Schatton T, Murphy GF, Molloy MJ, Zhan Q, Ramoni MF, Frank MH, Kohane IS, Gussoni E (2006) Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. J Cell Biol 175:99-110 (Pubitemid 44537202)
20. Suzuki M, Shigematsu H, Shames DS, Sunaga N, Takahashi T, Shivapurkar N, Iizasa T, Frenkel EP, Minna JD, Fujisawa T, Gazdar AF (2005) DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers. Br J Cancer 93:1029-1037 (Pubitemid 41548398)
21. Brunet LJ, McMahon JA, McMahon AP, Harland RM (1998) Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science 280:1455-1457 (Pubitemid 28264842)
22. Gazzerro E, Gangji V, Canalis E (1998) Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts. J Clin Invest 102:2106-2114 (Pubitemid 29018817)
23. Stafford DA, Brunet LJ, Khokha MK, Economides AN, Harland RM (2011) Cooperative activity of noggin and gremlin 1 in axial skeleton development. Development 138:1005-1014