Antiplatelet therapy preceding coronary artery surgery: Implications for bleeding, transfusion requirements and outcome

European Journal of Anaesthesiology

Volumn 24, Issue 4, 2007, Pages 332-339

  Picker, Susanne M ^a   Kaleta, T ^a   Hekmat, K ^a   Kampe, S ^a   Gathof, B S ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Aspirin; Blood transfusion; Cardiac surgery; Cardiopulmonary bypass; Clopidogrel; Coronary artery bypass; Platelet aggregation inhibitors; Ticlopidine

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; TICLOPIDINE;

ADULT; AGED; ARTICLE; BLEEDING; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY SURGERY; ERYTHROCYTE; FEMALE; HEART INFARCTION; HUMAN; INFARCTION; INTENSIVE CARE UNIT; INTRAOPERATIVE PERIOD; MALE; OUTCOME ASSESSMENT; PLASMA; PREOPERATIVE PERIOD; RETROSPECTIVE STUDY; THROMBOCYTE; TRANSFUSION; TUBE;

ADULT; AGED; BLOOD TRANSFUSION; CORONARY ARTERY BYPASS; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; POSTOPERATIVE HEMORRHAGE; RETROSPECTIVE STUDIES;

EID: 33847022346     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1017/S0265021506002262     Document Type: Article

References (43)

1. Hekmat K, Menzel C, Kroener A et al. The effect of preoperative antiplatelet therapy in coronary artery surgery: blood transfusion requirements for patients on cardiopulmonary bypass. Curr Med Res Opin 2004; 20: 1429-1435.
2. Pollack CV, Gibler WB. 2000 ACC/AHA guideline for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: a practical summary for emergency physicians. Ann Emerg Med 2001; 38: 229-240.
3. Antman EM, Fox KM. Guidelines for the diagnosis and management of unstable angina and non Q-wave myocardial infarction: proposed revisions. International Cardiology Forum. Am Heart J 2000; 139: 461-475.
4. Bertrand ME, Rupprecht HJ, Urban P et al. Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: the clopidogrel aspirin stent international cooperative study (CLASSICS). Circulation 2000; 102: 624-629.
5. Fox KA, Mehta SR, Peters R et al. Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the clopidogrel in unstable angina to prevent recurrent ischemic events (CURE) trial. Circulation 2004; 110: 1202-1208.
6. Ferraris VA, Ferraris SP. Preoperative aspirin ingestion increases operative blood loss after coronary artery bypass grafting [Updated in 1995]. Ann Thorac Surg 1995; 59: 1036-1037.
7. Taggart DP, Siddiqui A, Wheatley DJ. Low dose preoperative aspirin therapy, postoperative blood loss, and transfusion requirements. Ann Thorac Surg 1990; 50: 424-428.
8. Sethi GK, Copeland JG, Goldman S, Moritz T, Zadina K, Henderson WG. Implications of preoperative administration of aspirin in patients undergoing coronary artery bypass grafting. Department of Veterans Affairs Cooperative Study on Antiplatelet Therapy. J Am Coll Cardiol 1990; 15: 15-20.
9. Boldt J, Knothe C, Zickmann B, Herold C, Dapper F, Hempelmann G. The effects of preoperative aspirin therapy on platelet function in cardiac surgery. Eur J Cardiothorac Surg 1992; 6: 598-602.
10. Kallis P, Tooze JA, Talbot S, Cowans D, Bevan DH, Treasure T. Pre-operative aspirin decreases platelet aggregation and increases post-operative blood loss - a prospective, randomized, placebo-controlled, double-blind clinical trial in 100 patients with chronic stable angina. Eur J Cardiothorac Surg 1994; 8: 404-409.
11. Bracey AW, Radovancevic R, Radovancevic B, McAllister Jr HA, Vaughn WK, Cooley DA. Blood use in patients undergoing repeat coronary artery bypass graft procedures: multivariate analysis. Transfusion 1995; 35: 850-854.
12. Bashein G, Nessly ML, Rice AL, Counts RB, Misbach GA. Preoperative aspirin therapy and reoperation for bleeding after coronary artery bypass surgery. Arch Intern Med 1991; 151: 89-93.
13. Pothula S, Sanchala VT, Nagappala B, Inchiosa Jr MA. The effect of preoperative antiplatelet/anticoagulant prophylaxis on postoperative blood loss in cardiac surgery. Anesth Analg 2004; 98: 4-10.
14. Burger W, Chemnitius JM, Kneissl GD, Rücker G. Low-dose aspirin for secondary cardiovascular prevention -cardiovascular risks after its perioperative withdrawl versus bleeding risks with its continuation - review and meta-analysis. J Int Med 2005; 257: 399-414.
15. Rawitscher RE, Jones JW, McCoy TA, Lindsley DA. A prospective study of aspirin's effect on red blood cell loss in cardiac surgery. J Cardiothorac Surg 1991; 32: 1-7.
16. Vuylsteke A, Oduro A, Cardan E, Latimer RD. Effect of aspirin in coronary artery bypass grafting. J Cardiothorac Vasc Anesth 1997; 11: 831-834.
17. Reich DL, Patel GC, Vela-Cantos F, Bodian C, Lansman S. Aspirin does not increase homologous blood requirements in elective coronary bypass surgery. Anesth Analg 1994; 79: 4-8.
18. Tuman KJ, McCarthy RJ, O'Connor CJ, McCarthy WE, Ivankovich AD. Aspirin does not increase allogeneic blood transfusion in reoperative coronary artery surgery. Anesth Analg 1996; 83: 1178-1184.
19. Moulton MJ, Creswell LL, Mackey ME, Cox JL, Rosenbloom M. Reexploration for bleeding in a risk factor for adverse outcomes after cardiac operations. J Thorac Cardiovasc Surg 1996; 111: 1037-1046.
20. Collet JP, Himbet F, Steg PG. Myocardial infarction after aspirin cessation in stable coronary artery disease patients. Int J Cardiol 2000; 76: 257-258.
21. Ferrari E, Benhamou M, Cerboni P, Badouy M. Coronary syndromes following aspirin withdrawal. Chest 2003; 124: 148S.
22. Senior K. Aspirin withdrawal increases risk of heart problems. Lancet 2003; 362: 1558.
23. Mangano DT. Aspirin and mortality from coronary bypass surgery. N Eng J Med 2002; 347: 1309-1317.
24. Calafiore AM, Teodori G, Rondelez L et al. Intermittent antegrad warm blood cardioplegia. Ann Thorac Surg 1995; 59: 398-402.
25. Hekmat K, Zimmermann T, Kampe S et al. Impact of tranexamic acid vs. aprotinin on blood loss and transfusion requirements after cardiopulmonary bypass: a prospective, randomised, double-blind trial. Curr Med Res Opin 2004; 20: 121-126.
26. Roques F, Michel P, Goldstone AR, Nashef SA. The logistic EuroSCORE. Eur Heart J 2003; 24: 882.
27. Ferraris VA, Ferraris SP, Joseph O, Wehner P, Mentzer Jr RM. Aspirin and postoperative bleeding after coronary artery bypass grafting. Ann Surg 2002; 235: 820-827.
28. Menichetti A, Tritapepe L, Ruvolo G et al. Changes in coagulation patterns, blood loss, and blood use after cardiopulmonary bypass: aprotinin vs. tranexamic acid vs. epsilon aminocaproic acid. J Cardiovasc Surg 1996; 37: 401-407.
29. Mangano DT, Tudor JC, Dietzel C. The risk associated with aprotinin in cardiac surgery. N Eng J Med 2006; 354: 353-365.
30. Weightman WM, Gibbs NM, Weidmann CR et al. The efffect of preoperative-aspirin free interval on red blood cell transfusion requirements in cardiac surgical patients. J Cardiothorac Vasc Anesth 2002; 16: 54-58.
31. Schomig A, Neumann FJ, Kastrati A. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Eng J Med 1996; 334: 1084-1089.
32. Leon MB, Baim DS, Popma JJ. A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. Stent Anticoagulation Restenosis Study Investigators. N Eng J Med 1998; 339: 1665-1671.
33. Schmidtler F, Gansera B, Spiliopoulos K, Angelis I, Neumaier-Prauser P, Kemkes BM. Urgent or emergent coronary revascularization using bilateral internal thoracic artery after previous clopidogrel antiplatelet therapy. Z Kardiol 2004; 93: 679-685.
34. Hongo RH, Ley J, Dick SE, Yee RR. The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting. J AM Coll Cardiol 2002; 40: 231-237.
35. Yende S, Wunderink RG. Effect of clopidogrel on bleeding after coronary artery bypass surgery. Crit Care Med 2001; 29: 2271-2275.
36. Ray JG, Deniz S, Olivieri A et al. Increased blood product use among coronary artery bypass patients prescribed preoperative aspirin and clopidogrel. BMC Cardiovasc Disord 2003; 22: 3.
37. Pritzbuer von E. Können aorto-koronare Bypass Operationen durch den Einsatz der präoperativen Eigenblutspende ohne Fremdblut durchgeführt werden? Inaugural dissertation at the University Hospital of Cologne, 2003: 26-28.
38. Leal-Noval SR, Rincon-Ferrari MD, Garcia-Curiel A et al. Transfusion of blood components and postoperative infection in patients undergoing cardiac surgery. Chest 2001; 119: 1461-1468.
39. Vamvakas EC, Carven HJ. Red blood cell transfusion and postoperative length of stay in the hospital or the intensive care unit among patients undergoing coronary artery bypass surgery: the effect of confounding factors. Transfusion 2000; 40: 832-839.
40. Klein M, Keith PR, Dauben HP et al. Aprotinin counterbalances an increased risk of peri-operative hemorrhage in CABG patients pre-treated with aspirin. Eur J Cardiothorac Surg 1998; 14: 360-366.
41. Harder S, Klinkhardt U, Alvarez JM. Avoidance of bleeding during surgery in patients receiving anticoagulant and/or antiplatelet therapy: pharmacokinetic and pharmacodynamic considerations. Clin Pharmacokinet 2004; 43: 963-981.
42. Samama CM, Albaladejo P, Benhamou D et al. Venous thromboembolism prevention in surgery and obstetrics: clinical practice guidelines. Eur J Anest 2006; 23: 95-116.
43. Sundt TM, Kouchoukos NT, Saffitz JE, Murphy SF, Wareing TH, Stahl DJ. Renal dysfunction and intravascular coagulation with aprotinin and hypothermic circulatory arrest. Ann Thorac Surg 1993; 55: 1418-1424.