Increase of α-SMA + and CK + cells as an early sign of epithelial-mesenchymal transition during colorectal carcinogenesis

Pathology and Oncology Research

Volumn 18, Issue 2, 2012, Pages 371-376

  Valcz, Gábor ^a   Sipos, Ferenc ^a   Krenács, Tibor ^a   Molnár, Jeannette ^b   Patai, Árpád V ^a   Leiszter, Katalin ^a   Tóth, Kinga ^a   Wichmann, Barna ^a   Molnár, Béla ^c   Tulassay, Zsolt ^c  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b National Institute of Food and Nutrition Science   (Hungary)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Adenoma carcinoma sequence; Alpha smooth muscle actin; Cytokeratin; Epithelial myofibroblast transition

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CYTOKERATIN; KI 67 ANTIGEN; UVOMORULIN;

ADULT; ARTICLE; CELL CONTACT; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL ARTICLE; COLON BIOPSY; COLON CARCINOGENESIS; COLONOSCOPY; COLORECTAL ADENOMA; COLORECTAL CANCER; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ACTINS; ADENOMA; CADHERINS; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; COLON; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; EPITHELIAL-MESENCHYMAL TRANSITION; FOLLOW-UP STUDIES; HUMANS; IMMUNOENZYME TECHNIQUES; KERATINS; LONGITUDINAL STUDIES; NEOPLASM STAGING; PROGNOSIS; RECTUM; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84863479688     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-011-9454-z     Document Type: Article

References (31)

1. + and Cl-conductances in the distal colon of the rat. Gen Pharmacol 31:337-342
2. Lu L, Walker WA (2001) Pathologic and physiologic interactions of bacteria with thegastrointestinal epithelium. Am J Clin Nutr 73:1124-1130
3. Edmonds CJ (1984) Absorption and secretion of fluid and electrolytes by the rectum. Scand J Gastroenterol Suppl 93:79-87
4. Hollier BG, Evans K, Mani SA (2009) The epithelial-tomesenchymal transition and cancer stem cells: a coalition against cancer therapies. J Mammary Gland Biol Neoplasia 14:29-43
5. Thiery JP, Acloque H, Huang RYet al (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139:871-890
6. Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420-1428
7. Kalluri R (2009) EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest 119:1417-1419
8. Hugo H, Ackland ML, Blick T et al (2007) Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J Cell Physiol 213:374-383
9. Radisky DC (2005) Epithelial-mesenchymal transition. J Cell Sci 118:4325-4326
10. Boyer B, Vallés AM, Edme N (2000) Induction and regulation of epithelial-mesenchymal transitions. Biochem Pharmacol 60:1091-1099
11. Zavadil J, Bottinger EP (2005) TGF-β and epithelial-tomesenchymal transitions. Oncogene 24:5764-5774
12. Lorusso G, Rüegg C (2008) The tumor microenvironment and its contribution to tumor evolution toward metastasis. Histochem Cell Biol 130:1091-1103
13. Miyazono K (2009) Transforming growth factor-beta signaling in epithelial-mesenchymal transition and progression of cancer. Proc Jpn Acad Ser B Phys Biol Sci 85:314-323
14. Masszi A, Speight P, Charbonney E et al (2010) Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3. J Cell Biol 188:383-399
15. Masszi A, Fan L, Rosivall L, McCulloch CA et al (2004) Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin. Am J Pathol 165:1955-1967
16. Reichert M, Müller T, Hunziker W (2000) The PDZ domains of zonula occludens-1 induce an epithelial to mesenchymal transition of Madin-Darby canine kidney I cells. Evidence for a role of betacatenin/Tcf/Lef signaling. J Biol Chem 275:9492-9500
17. Wang J, Zohar R, McCulloch CA (2006) Multiple roles of alphasmooth muscle actin in mechanotransduction. Exp Cell Res 312:205-214
18. Li H, Fan X, Houghton J (2007) Tumor microenvironment: the role of the tumor stroma in cancer. J Cell Biochem 101:805-815
19. Jass JR (2007) Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology 50:113-130
20. Storch KN, Taatjes DJ, Bouffard NA et al (2007) Alpha smooth muscle actin distribution in cytoplasm and nuclear invaginations of connective tissue fibroblasts. Histochem Cell Biol 127:523-530
21. Thomas CH, Collier JH, Sfeir CS et al (2002) Engineering gene expression and protein synthesis by modulation of nuclear shape. Proc Natl Acad Sci USA 99:1972-1977
22. Wang J, Chen H, Seth A et al (2003) Mechanical force regulation of myofibroblast differentiation in cardiac fibroblasts. Am J Physiol Heart Circ Physiol 285:1871-1881
23. Gomez EW, Chen QK, Gjorevski N et al (2010) Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. J Cell Biochem 110:44-51
24. Ng YY, Huang TP, Yang WC et al (1998) Tubular epithelialmyofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. Kidney Int 54:864-876
25. Zhou BP, Deng J, Xia W et al (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelialmesenchymal transition. Nat Cell Biol 6:931-940
26. Batlle E, Sancho E, Franci C et al (2000) The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2:84-89
27. Brabletz T, Hlubek F, Spaderna S et al (2005) Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. Cells Tissues Organs 179:56-65
28. Hawinkels LJ, Verspaget HW, van der Reijden JJ et al (2009) Active TGF-beta1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence. Cancer Sci 100:663-670
29. Fan L, Sebe A, Péterfi Z et al (2007) Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway. Mol Biol Cell 18:1083-1097
30. Masszi A, Di Ciano C, Sirokmány G et al (2003) Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. Am J Physiol Renal Physiol 284:911-924
31. Pino MS, Kikuchi H, Zeng M et al (2010) Epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability. Gastroenterology 138:1406-1417