Oxidized phospholipid, 1-palmitoyl-2-(9'-oxo-nonanoyl)- glycerophosphocholine (PON-GPC), produced in the lung due to cigarette smoking, impairs immune function in macrophages

Lung

Volumn 190, Issue 2, 2012, Pages 169-182

  Kimura, Tomomi ^a   Shibata, Yoko ^a   Yamauchi, Keiko ^a   Igarashi, Akira ^a   Inoue, Sumito ^a   Abe, Shuichi ^a   Fujita, Kazuhiro ^b   Uosaki, Yoichi ^b   Kubota, Isao ^a  

^a YAMAGATA UNIVERSITY   (Japan)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Bactericidal activity; Innate immunity; Macrophage; Oxidized phospholipid; Surfactant

Indexed keywords

1 PALMITOYL 2 (9' OXO NONANOYL)GLYCEROPHOSPHOCHOLINE; GAMMA INTERFERON; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITRIC OXIDE; PHOSPHOLIPID DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERICIDAL ACTIVITY; CIGARETTE SMOKING; CONTROLLED STUDY; CYTOKINE PRODUCTION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; INNATE IMMUNITY; INTERFERON INDUCTION; LIQUID CHROMATOGRAPHY; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; TISSUE LEVEL;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; ANIMALS; APOPTOSIS; BRONCHOALVEOLAR LAVAGE FLUID; CELL SURVIVAL; CELLS, CULTURED; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; MALE; MICE; NADP; NITRIC OXIDE; OXIDATION-REDUCTION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHAGOCYTOSIS; PHOSPHATIDYLCHOLINES; PHOSPHOLIPIDS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SMOKING; STATISTICS, NONPARAMETRIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863466524     PISSN: 03412040     EISSN: 14321750     Source Type: Journal    
DOI: 10.1007/s00408-011-9331-2     Document Type: Article

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