Hexokinase II in CD133+ and CD133- hepatoma BEL-7402 cells

Pathology and Oncology Research

Volumn 18, Issue 2, 2012, Pages 377-381

  Gong, Lei ^a   Cui, Zhuqingqing ^a   Yu, Xin ^a   Wei, Yuhua ^a   Peng, Jirun ^a   Leng, Xisheng ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

BEL 7402; CD133; Hepatoma; Hexokinase II; Therapeutic target

Indexed keywords

CD133 ANTIGEN; COMPLEMENTARY DNA; HEXOKINASE; HEXOKINASE 2; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL POPULATION; CELL SELECTION; CELL SEPARATION; CELL STRAIN BEL 7402; COLORIMETRY; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; FLOW CYTOMETRY; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION;

ANTIGENS, CD; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; FLOW CYTOMETRY; GLYCOPROTEINS; HEXOKINASE; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER NEOPLASMS; NEOPLASTIC STEM CELLS; PEPTIDES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84863465609     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-011-9455-y     Document Type: Article

References (32)

1. Yin AH, Miraglia S (1997) AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood 90:5002-5012
2. Shmelkov SV, Clair R (2005) AC133/CD133/Prominin-1. Int J Biochem Cell Biol 37:715-719
3. Singh SK, Clarke ID (2003) Identification of a cancer stem cell in human brain tumors. Cancer Res 63:5821-5828
4. Singh SK, Hawkins C (2004) Identification of human brain tumor initiating cells. Nature 432:396-401
5. Bussolati B, Bruno S (2005) Isolation of renal progenitor cells from adult human kidney. Am J Pathol 166:545-555
6. O'Brien CA, Pollett A (2007) A human colon cancer cell capable of initiating tumor growth in immunodeficient mice. Nature 445:106-110
7. Ricci-Vitiani L, Lombardi DG (2007) Identification and expansion of human colon cancer-initiating cells. Nature 445:111-115
8. Hermann PC, Huber SL (2007) Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1:313-323
9. Li C, Heidt DG (2007) Identification of pancreatic cancer stem cells. Cancer Res 67:1030-1037
10. Collins AT, Barry PA (2005) Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 65:10946-10951
11. Suetsugu A, Nagaki M (2006) Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells. Biochem and Biophys Res Comm 351:820-824
12. Yin S, Li J (2007) CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int J Cancer 120:1444-1450
13. Warburg O (1956) On the origin of cancer cells. Science 123:309-314
14. Pedersen PL, Mathupala S (2002) Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention. Biochim Biophys Acta 1555:14-20
15. Wolf A, Agnihotri S, Micallef J et al (2011) Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme. J Exp Med 208:313-326
16. Adams V, Kempf W (1995) Determination of hexokinase isoenzyme I and II composition by RT-PCR: increased hexokinase isoenzyme II in human renal cell carcinoma. Biochem Mol Med 54:53-58
17. Rempel A, Bannasch P (1994) Differences in expression and intracellular distribution of hexokinase isoenzymes in rat liver cells of different transformation stages. Biochim Biophys Acta 1219:660-668
18. Nakashima RA, Paggi MG (1988) Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line. Cancer Res 48:913-919
19. Shinohara Y, Ichihara J (1991) Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130. FEBS Lett 291:55-77
20. Yasuda S, Arii S (2004) Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor-1á and its significance. J Hepato 40:117-123
21. Mandarino LJ, Printz RL (1995) Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle. Am J Physiol Endocrinol Metab 269:E701-E708
22. Uchida N, Buck DW (2000) Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci USA 97:14720-14725
23. Kemper K, Grandela C, Medema JP (2010) Molecular identification and targeting of colorectal cancer stem cells. Oncotarget 1:387-395
24. Zhang QZ, Shi SH (2010) A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy. Cancer Lett 289:151-160
25. Ulrike K, Mechthild K (2010) Cancer stem cells at the crossroads of current cancer therapy failures-Radiation oncology perspective. Semin Cancer Biol 20:116-124
26. Shinohara Y (2000) Identification and characterization of hexokinase isozyme predominantly expressed in malignant tumor cells. Yakugaku Zasshi 120:657-666
27. Golshani-Hebroni SG, Bessman SP (1997) Hexokinase binding to mitochondria: a basis for proliferative energy metabolism. J Bioenerg Biomembr 29:331-338
28. Plas DR, Thompson CB (2002) Cell metabolism in the regulation of programmed cell death. Trends Endocrinol Metab 13:75-78
29. Pastorino JG, Shulga N (2003) Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis. J Biol Chem 277:7610-7618
30. Kim W, Yoon JH (2007) Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma. Mol Cancer Ther 6:2554-2562
31. Ihrlund LS, Hernlund E, Khan O et al (2008) 3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs. Mol Oncol 2:94-101
32. Mathupala SP, Ko YH, Pedersen PL (2010) The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies. Biochim Biophys Acta 1797:1225-1230